HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16622419
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~Histone, Histone~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 140 Hs			1 129
+	Hs
		391597 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		594830 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		H2A1D_HUMAN (1-127): 6.03e-65: 194: 95.28
+	Hs
		935141 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H2A1A_HUMAN (1-129): 1.77e-67: 201: 92.25
+	Hs
		555348 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Hs
		934815 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00
+	Hs
		934946 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83
+	Mm
		935458 H31_MOUSE (5-134): 1.29e-52: 164: 48.86		Q8CGP4_MOUSE (1-129): 2.74e-66: 198: 89.15
+	Hs
		1086165 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00
+	Hs
		1086203 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83
+	Hs
		935170 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H2A1J_HUMAN (1-127): 9.26e-66: 196: 96.06
+	Hs
		470336 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06
+	Hs
		934877 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64
+	Hs
		1157222 H3C_HUMAN (5-134): 5.15e-52: 162: 47.69		H2A1J_HUMAN (1-127): 9.26e-66: 196: 96.06
+	Hs
		391649 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		1086182 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64
+	Hs
		1086192 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		H2A3_HUMAN (1-127): 5.35e-65: 195: 95.28
+	Hs
		470399 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06
+	Hs
		391723 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		555411 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Hs
		555485 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12