Protein: UBP21
Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)

Gene: UBP21, USP21
Organism: Homo sapiens
Interactions: 162
UniProt ID: Q9UK80

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508807

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

11

20

Small-scale

0.976

High

1460946

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

17

High-throughput

0.799

High

1289109

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

2

17

Small-scale

0.789

High

425672

ISG15
Ubiquitin-like protein ISG15

2

20

Small-scale

0.778

High

1437234

NANOG
Homeobox protein NANOG

4

2

Small-scale

0.715

High

170416

AURKA
Aurora kinase A

3

11

Small-scale

0.667

High

488567

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

3

10

High-throughput

0.667

High

288538

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

15

High-throughput

0.647

High

828259

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

14

High-throughput

0.647

High

930076

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

16

High-throughput

0.647

High

1094654

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

18

High-throughput

0.647

High

1258109

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

17

High-throughput

0.647

High

1353436

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

19

High-throughput

0.647

High

1371766

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

16

High-throughput

0.647

High

1402023

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

19

High-throughput

0.647

High

1460940

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

16

High-throughput

0.647

High

1460948

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

15

High-throughput

0.647

High

1218691

OTU1
Ubiquitin thioesterase OTU1

2

1

Small-scale

0.629

High

323056

WDR47
WD repeat-containing protein 47

1

6

Small-scale

0.621

High

692150

MARK3
MAP/microtubule affinity-regulating kinase 3

2

7

Small-scale

0.611

High

1270547

MARK2
Serine/threonine-protein kinase MARK2

2

8

Small-scale

0.611

High

1453872

MARK1
Serine/threonine-protein kinase MARK1

2

9

Small-scale

0.611

High

1160336

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

6

High-throughput

0.606

High

1452540

HXC10
Homeobox protein Hox-C10

2

1

High-throughput

0.606

High

966999

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

1049892

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

414810

P53
Cellular tumor antigen p53

2

5

Small-scale

0.595

High

1109679

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

8

Small-scale

0.595

High

1213159

BEND3
BEN domain-containing protein 3

2

0

Small-scale

0.585

High

662671

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

2

1

Small-scale

0.584

High

1061624

FOXM1
Forkhead box protein M1

1

1

Small-scale

0.578

High

1227670

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.575

High

1230309

K1C40
Keratin, type I cytoskeletal 40

1

17

High-throughput

0.573

High

675718

TYY1
Transcriptional repressor protein YY1

1

2

Small-scale

0.561

High

351619

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

2

High-throughput

0.553

High

1250332

ATL4
ADAMTS-like protein 4

2

1

High-throughput

0.553

High

1271424

KCTD9
BTB/POZ domain-containing protein KCTD9

2

5

High-throughput

0.553

High

1335257

KCTD6
BTB/POZ domain-containing protein KCTD6

1

5

Small-scale

0.552

High

904411

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.537

High

177328

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

5

High-throughput

0.536

High

656270

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

4

High-throughput

0.536

High

835774

KPCI
Protein kinase C iota type

1

5

High-throughput

0.536

High

862731

UTRN
Utrophin

1

3

High-throughput

0.536

High

972110

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.536

High

990848

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

1204820

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

3

High-throughput

0.536

High

1307532

RBM45
RNA-binding protein 45

1

6

High-throughput

0.536

High

1460951

RBM8A
RNA-binding protein 8A

1

6

High-throughput

0.536

High

402464

FUCO
Tissue alpha-L-fucosidase

1

0

High-throughput

0.513

High

1419957

REN3B
Regulator of nonsense transcripts 3B

1

0

High-throughput

0.513

High

583904

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

10

High-throughput

0.501

High

691874

MK03
Mitogen-activated protein kinase 3

1

1

Small-scale

0.501

High

755023

H2B1B
Histone H2B type 1-B

1

14

Small-scale

0.501

High

883358

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

Small-scale

0.501

High

906820

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

2

Small-scale

0.501

High

927165

ATX3
Ataxin-3

1

2

High-throughput

0.501

High

1139190

JOS1
Josephin-1

1

2

High-throughput

0.501

High

1162720

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

5

Small-scale

0.501

High

1364669

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

10

High-throughput

0.501

High

1380880

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.501

High

1387348

OTUB2
Ubiquitin thioesterase OTUB2

1

4

High-throughput

0.501

High

1391071

OTUB1
Ubiquitin thioesterase OTUB1

1

4

High-throughput

0.501

High

1397029

SENP8
Sentrin-specific protease 8

1

3

High-throughput

0.501

High

1419263

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.501

High

1433799

SENP3
Sentrin-specific protease 3

1

3

High-throughput

0.501

High

1460949

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.501

High

1032263

EXOSX
Exosome complex component 10

1

0

High-throughput

0.486

High

651457

CBL
E3 ubiquitin-protein ligase CBL

1

5

High-throughput

0.481

High

783450

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.481

High

898264

R144A
E3 ubiquitin-protein ligase RNF144A

1

7

High-throughput

0.481

High

1248451

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

2

High-throughput

0.481

High

1331923

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

4

High-throughput

0.481

High

1338587

SYNE1
Nesprin-1

1

4

Small-scale

0.481

High

1410838

SLF1
SMC5-SMC6 complex localization factor protein 1

1

8

Small-scale

0.481

High

1418414

PCGF6
Polycomb group RING finger protein 6

1

15

High-throughput

0.481

High

1418836

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

10

High-throughput

0.481

High

1420191

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

20

High-throughput

0.481

High

1420545

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

20

High-throughput

0.481

High

1420577

TRIM5
Tripartite motif-containing protein 5

1

14

High-throughput

0.481

High

1460943

CBLC
E3 ubiquitin-protein ligase CBL-C

1

5

High-throughput

0.481

High

340688

STABP
STAM-binding protein

1

0

High-throughput

0.480

High

1129581

ESPL1
Separin

1

0

High-throughput

0.480

High

155036

BHE40
Class E basic helix-loop-helix protein 40

1

1

Small-scale

0.479

High

166205

AIM2
Interferon-inducible protein AIM2

1

2

Small-scale

0.479

High

176893

DCLK1
Serine/threonine-protein kinase DCLK1

1

4

High-throughput

0.479

High

219756

FOXO3
Forkhead box protein O3

1

1

Small-scale

0.479

High

230588

KIF1C
Kinesin-like protein KIF1C

1

3

High-throughput

0.479

High

245285

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

7

High-throughput

0.479

High

252188

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

2

High-throughput

0.479

High

269631

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

2

High-throughput

0.479

High

281451

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.479

High

339118

NADK
NAD kinase

1

1

High-throughput

0.479

High

344446

IL33
Interleukin-33

1

1

Small-scale

0.479

High

345129

RIGI
Antiviral innate immune response receptor RIG-I

1

14

Small-scale

0.479

High

350174

SNAI1
Zinc finger protein SNAI1

1

7

Small-scale

0.479

High

466713

GLI1
Zinc finger protein GLI1

1

1

Small-scale

0.479

High

487867

PARP1
Poly [ADP-ribose] polymerase 1

1

6

Small-scale

0.479

High

517502

GLI2
Zinc finger protein GLI2

1

1

Small-scale

0.479

High

637973

NF1
Neurofibromin

1

4

High-throughput

0.479

High

681739

PSA4
Proteasome subunit alpha type-4

1

3

High-throughput

0.479

High

698385

MAP4
Microtubule-associated protein 4

1

12

Small-scale

0.479

High

719277

MPIP2
M-phase inducer phosphatase 2

1

2

High-throughput

0.479

High

765099

CTNB1
Catenin beta-1

1

9

Small-scale

0.479

High

783076

TCF7
Transcription factor 7

1

3

Small-scale

0.479

High

870659

MAOX
NADP-dependent malic enzyme

1

3

Small-scale

0.479

High

936479

AFAD
Afadin

1

4

High-throughput

0.479

High

941084

HDAC4
Histone deacetylase 4

1

7

High-throughput

0.479

High

1025604

CDK16
Cyclin-dependent kinase 16

1

5

High-throughput

0.479

High

1055998

RAD51
DNA repair protein RAD51 homolog 1

1

1

Small-scale

0.479

High

1092512

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.479

High

1101926

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

1114614

CUL3
Cullin-3

1

10

Small-scale

0.479

High

1119916

CKAP5
Cytoskeleton-associated protein 5

1

7

Small-scale

0.479

High

1129992

MELK
Maternal embryonic leucine zipper kinase

1

9

High-throughput

0.479

High

1216105

SPD2A
SH3 and PX domain-containing protein 2A

1

5

High-throughput

0.479

High

1219636

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.479

High

1229417

KCD11
BTB/POZ domain-containing protein KCTD11

1

4

Small-scale

0.479

High

1235013

PKHA7
Pleckstrin homology domain-containing family A member 7

1

12

High-throughput

0.479

High

1286558

PHLB2
Pleckstrin homology-like domain family B member 2

1

13

High-throughput

0.479

High

1309262

KSR1
Kinase suppressor of Ras 1

1

5

High-throughput

0.479

High

1349483

F110B
Protein FAM110B

1

2

High-throughput

0.479

High

1352621

DEN1A
DENN domain-containing protein 1A

1

1

High-throughput

0.479

High

1360415

SRS12
Serine/arginine-rich splicing factor 12

1

5

High-throughput

0.479

High

1371085

ARHG2
Rho guanine nucleotide exchange factor 2

1

2

Small-scale

0.479

High

1385371

DHX58
ATP-dependent RNA helicase DHX58

1

12

Small-scale

0.479

High

1396682

MARK4
MAP/microtubule affinity-regulating kinase 4

1

9

High-throughput

0.479

High

1400874

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.479

High

1401135

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

6

High-throughput

0.479

High

1410265

F110A
Protein FAM110A

1

2

High-throughput

0.479

High

1419403

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

13

Small-scale

0.479

High

1447278

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.479

High

1454247

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

2

High-throughput

0.479

High

1454770

HECW2
E3 ubiquitin-protein ligase HECW2

1

11

High-throughput

0.479

High

1459744

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.479

High

1460362

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

11

Small-scale

0.479

High

1460596

NGAP
Ras GTPase-activating protein nGAP

1

3

High-throughput

0.479

High

1460942

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

1460945

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.479

High

1460947

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1460950

KCTD3
BTB/POZ domain-containing protein KCTD3

1

4

High-throughput

0.479

High

1023988

EM55
55 kDa erythrocyte membrane protein

1

0

Small-scale

0.460

High

1429074

ZN350
Zinc finger protein 350

1

0

Small-scale

0.460

High

208752

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.458

High

1134081

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1216035

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

0

High-throughput

0.458

High

1402226

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.458

High

1409799

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1412891

RTKN
Rhotekin

1

0

High-throughput

0.458

High

1454070

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.458

High

1460941

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1232741

H2A2A
Histone H2A type 2-A

1

14

Small-scale

0.457

High

1391930

RN185
E3 ubiquitin-protein ligase RNF185

1

7

High-throughput

0.439

High

942476

GSC
Homeobox protein goosecoid

1

2

Small-scale

0.437

High

1229909

AN34A
Ankyrin repeat domain-containing protein 34A

1

12

High-throughput

0.437

High

1257053

SYDE1
Rho GTPase-activating protein SYDE1

1

3

High-throughput

0.437

High

1357443

DEP1B
DEP domain-containing protein 1B

1

4

High-throughput

0.437

High

1460944

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.437

High

275430

O75271
non-specific serine/threonine protein kinase

1

5

High-throughput

0.407

High

1161861

FOXD1
Forkhead box protein D1

1

0

Small-scale

0.292

High

1187146

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.249

Low

1452550

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025