HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 140 Hs			1 1437
+	Hs
		935205 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		NSD3_HUMAN (1-1437): 0: 1169: 100.00
+	Hs
		331748 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		331780 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		828177 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		855452 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		935237 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SUV92_HUMAN (903-1285): 1.04e-77: 265: 23.22
+	Hs
		203659 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		828381 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		935276 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		ASH1L_HUMAN (1002-1314): 3.35e-61: 234: 29.85
+	Hs
		935126 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		935204 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		935251 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		934804 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		828202 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		934681 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		828350 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		NSD1_HUMAN (91-724): 2.53e-28: 126: 15.30
+	Hs
		935129 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		NSD1_HUMAN (91-724): 2.53e-28: 126: 15.30
+	Hs
		935004 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		KMT2C_HUMAN (1278-1411): 2.31e-13: 77.9: 15.75
+	Hs
		828421 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		KMT2B_HUMAN (1323-1421): 9.58e-09: 62.5: 19.83
+	Hs
		935368 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		KMT2B_HUMAN (1323-1421): 9.58e-09: 62.5: 19.83