HitPredict

Interactor 1: PSB3 (P49720)
Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)
Gene: PSMB3

Interactor 2: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 908
+	Hs
		656593 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		656707 PSB5_HUMAN (8-197): 1.9e-66: 206: 22.63		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		594520 PSB1_HUMAN (2-205): 1.85e-65: 203: 23.94		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Dm
		771429 PSB1_DROME (2-205): 3.62e-70: 215: 26.51		Q9VW54_DROME (3-906): 0: 1063: 60.65
+	Dm
		1375001 PSB3_DROME (1-205): 1.69e-67: 207: 63.90		Q9VW54_DROME (3-906): 0: 1063: 60.65
+	Dm
		1178970 Q7K148_DROME (8-195): 1.2e-65: 205: 23.94		Q9VW54_DROME (3-906): 0: 1063: 60.65
+	Dm
		47629 A0AQH0_DROME (7-199): 4.68e-66: 204: 24.35		Q9VW54_DROME (3-906): 0: 1063: 60.65
+	Sp
		195131 PSB1_SCHPO (8-199): 1.63e-65: 203: 25.00		RPN1_SCHPO (8-905): 0: 1025: 47.67
+	Hs
		832033 PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Hs
		656638 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Hs
		656760 PSB5_HUMAN (8-197): 1.9e-66: 206: 22.63		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Hs
		594615 PSB1_HUMAN (2-205): 1.85e-65: 203: 23.94		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Hs
		694 PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00		A0A087WW66_HUMAN (59-845): 0: 709: 17.00
+	Dm
		771411 PSB1_DROME (2-205): 3.62e-70: 215: 26.51		PSMD1_DROME (59-845): 0: 710: 17.07
+	Hs
		690 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		A0A087WW66_HUMAN (59-845): 0: 709: 17.00
+	Dm
		1359020 PSB3_DROME (1-205): 1.69e-67: 207: 63.90		PSMD1_DROME (59-845): 0: 710: 17.07
+	Dm
		1178951 Q7K148_DROME (8-195): 1.2e-65: 205: 23.94		PSMD1_DROME (59-845): 0: 710: 17.07
+	Hs
		691 PSB5_HUMAN (8-197): 1.9e-66: 206: 22.63		A0A087WW66_HUMAN (59-845): 0: 709: 17.00
+	Dm
		47613 A0AQH0_DROME (7-199): 4.68e-66: 204: 24.35		PSMD1_DROME (59-845): 0: 710: 17.07
+	Hs
		684 PSB1_HUMAN (2-205): 1.85e-65: 203: 23.94		A0A087WW66_HUMAN (59-845): 0: 709: 17.00