Protein: IF2G
Eukaryotic translation initiation factor 2 subunit gamma (eIF2-gamma) (EC 3.6.5.3)

Gene: IF2G, GCD11
Organism: Saccharomyces cerevisiae S288C
Interactions: 177
UniProt ID: P32481

Gene Ontology (top 5):
GO:0001731 - formation of translation preinitiation complex
GO:0003743 - translation initiation factor activity
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

632868

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

15

8

Small-scale

0.986

High

478598

IF2B
Eukaryotic translation initiation factor 2 subunit beta

15

7

Small-scale

0.986

High

737713

IF5
Eukaryotic translation initiation factor 5

10

11

Small-scale

0.975

High

737776

CD123
Translation initiation factor eIF2 assembly protein

10

5

Small-scale

0.877

High

737727

IF2P
Eukaryotic translation initiation factor 5B

2

10

Small-scale

0.776

High

478401

EI2BG
Translation initiation factor eIF2B subunit gamma

9

8

Small-scale

0.757

High

737691

EI2BE
Translation initiation factor eIF2B subunit epsilon

9

8

Small-scale

0.752

High

737692

EI2BB
Translation initiation factor eIF2B subunit beta

8

7

Small-scale

0.749

High

555296

EI2BD
Translation initiation factor eIF2B subunit delta

6

7

Small-scale

0.732

High

737710

EIF3A
Eukaryotic translation initiation factor 3 subunit A

5

4

Small-scale

0.709

High

575316

EI2BA
Translation initiation factor eIF2B subunit alpha

4

7

High-throughput

0.697

High

737690

EIF3C
Eukaryotic translation initiation factor 3 subunit C

4

4

High-throughput

0.694

High

737762

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

7

High-throughput

0.691

High

737688

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

13

High-throughput

0.665

High

438400

EIF3B
Eukaryotic translation initiation factor 3 subunit B

3

4

Small-scale

0.650

High

737757

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

High-throughput

0.618

High

688979

RL16A
Large ribosomal subunit protein uL13A

2

5

High-throughput

0.611

High

737770

EIF3G
Eukaryotic translation initiation factor 3 subunit G

2

13

Small-scale

0.611

High

737696

PP12
Serine/threonine-protein phosphatase PP1-2

3

3

Small-scale

0.599

High

737709

LSM2
LSM complex subunit LSM2

1

2

High-throughput

0.587

High

544175

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.584

High

726845

HS104
Heat shock protein 104

2

8

High-throughput

0.584

High

737698

RSSA1
Small ribosomal subunit protein uS2A

2

9

Small-scale

0.584

High

737740

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

16

High-throughput

0.584

High

394354

EF1A
Elongation factor 1-alpha

1

10

High-throughput

0.575

High

737730

LSM5
LSM complex subunit LSM5

1

0

High-throughput

0.549

High

434143

RL36A
Large ribosomal subunit protein eL36A

1

3

High-throughput

0.536

High

655415

RS3A2
Small ribosomal subunit protein eS1B

1

7

High-throughput

0.536

High

712523

RL8B
Large ribosomal subunit protein eL8B

1

3

High-throughput

0.536

High

737712

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.536

High

737720

DMA1
E3 ubiquitin-protein ligase DMA1

1

1

High-throughput

0.536

High

737723

TEM1
Protein TEM1

1

3

High-throughput

0.536

High

737754

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.536

High

737766

GCN5
Histone acetyltransferase GCN5

1

6

High-throughput

0.536

High

737796

RL11B
Large ribosomal subunit protein uL5B

1

5

High-throughput

0.536

High

737797

RS22B
Small ribosomal subunit protein uS8B

1

4

High-throughput

0.536

High

737760

H3
Histone H3

2

7

High-throughput

0.521

High

670470

SIS1
Protein SIS1

1

8

High-throughput

0.515

High

737746

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

3

High-throughput

0.514

High

737747

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.513

High

441069

KAPA
cAMP-dependent protein kinase type 1

1

11

Small-scale

0.501

High

646345

RAD53
Serine/threonine-protein kinase RAD53

1

1

Small-scale

0.501

High

737767

PKH1
Serine/threonine-protein kinase PKH1

1

10

Small-scale

0.501

High

439289

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.500

High

459053

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.489

High

617378

GBB
Guanine nucleotide-binding protein subunit beta

1

11

High-throughput

0.489

High

644886

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

6

High-throughput

0.489

High

688728

RFA2
Replication factor A protein 2

1

6

High-throughput

0.489

High

702233

YJU2
Splicing factor YJU2

1

1

High-throughput

0.489

High

721772

XPO1
Exportin-1

1

10

High-throughput

0.489

High

737707

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

11

High-throughput

0.489

High

737749

FMP48
Probable serine/threonine-protein kinase FMP48

1

9

High-throughput

0.489

High

737775

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

1

High-throughput

0.489

High

737791

RAD59
DNA repair protein RAD59

1

1

High-throughput

0.489

High

367720

ENO1
Enolase 1

1

0

High-throughput

0.479

High

737728

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.479

High

149650

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

383583

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.479

High

392420

HSP82
ATP-dependent molecular chaperone HSP82

1

11

High-throughput

0.479

High

410000

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.479

High

433517

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.479

High

434926

RS3
Small ribosomal subunit protein uS3

1

7

High-throughput

0.479

High

435845

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

436351

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

8

High-throughput

0.479

High

441778

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.479

High

454937

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.479

High

502916

RS22A
Small ribosomal subunit protein uS8A

1

4

High-throughput

0.479

High

504101

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.479

High

512322

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.479

High

512886

RS8A
Small ribosomal subunit protein eS8A

1

4

High-throughput

0.479

High

513836

RS11B
Small ribosomal subunit protein uS17B

1

5

High-throughput

0.479

High

514247

RL12B
Large ribosomal subunit protein uL11B

1

3

High-throughput

0.479

High

514519

RS18A
Small ribosomal subunit protein uS13A

1

3

High-throughput

0.479

High

558640

CAF20
Cap-associated protein CAF20

1

1

Small-scale

0.479

High

579043

HSC82
ATP-dependent molecular chaperone HSC82

1

11

High-throughput

0.479

High

657064

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

Small-scale

0.479

High

674485

RS2
Small ribosomal subunit protein uS5

1

7

High-throughput

0.479

High

679484

CDC48
Cell division control protein 48

1

6

High-throughput

0.479

High

689331

RS7A
Small ribosomal subunit protein eS7A

1

3

High-throughput

0.479

High

737702

RS3A1
Small ribosomal subunit protein eS1A

1

7

High-throughput

0.479

High

737704

RS27A
Small ribosomal subunit protein eS27A

1

7

High-throughput

0.479

High

737706

GBLP
Small ribosomal subunit protein RACK1

1

14

High-throughput

0.479

High

737708

ATG8
Autophagy-related protein 8

1

15

High-throughput

0.479

High

737715

RS20
Small ribosomal subunit protein uS10

1

4

High-throughput

0.479

High

737721

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

737726

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

737733

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

13

Small-scale

0.479

High

737735

RL34B
Large ribosomal subunit protein eL34B

1

2

High-throughput

0.479

High

737745

RS12
Small ribosomal subunit protein eS12

1

4

High-throughput

0.479

High

737750

EIF2A
Eukaryotic translation initiation factor 2A

1

4

High-throughput

0.479

High

737763

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

737784

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

448292

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

1

High-throughput

0.470

High

671939

HAL4
Serine/threonine-protein kinase HAL4/SAT4

1

9

High-throughput

0.470

High

737695

STH1
Nuclear protein STH1/NPS1

1

5

High-throughput

0.470

High

737697

RT04
Small ribosomal subunit protein uS2m

1

9

High-throughput

0.470

High

737772

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

737786

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

548888

SCH9
Serine/threonine-protein kinase SCH9

1

8

Small-scale

0.457

High

453481

PYR1
Multifunctional protein URA2

1

6

High-throughput

0.445

High

523369

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

569937

RL3
Large ribosomal subunit protein uL3

1

3

High-throughput

0.445

High

675817

MAS5
Mitochondrial protein import protein MAS5

1

9

High-throughput

0.445

High

737693

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

737694

HSP79
Heat shock protein homolog SSE2

1

12

High-throughput

0.445

High

737717

RL14B
Large ribosomal subunit protein eL14B

1

3

High-throughput

0.445

High

737719

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

737731

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

737732

RL13B
Large ribosomal subunit protein eL13B

1

3

High-throughput

0.445

High

737737

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.445

High

737742

RSSA2
Small ribosomal subunit protein uS2B

1

9

High-throughput

0.445

High

737758

APJ1
J domain-containing protein APJ1

1

10

High-throughput

0.445

High

737789

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.445

High

737790

RL7B
Large ribosomal subunit protein uL30B

1

4

High-throughput

0.445

High

737701

XPOT
Exportin-T

1

11

Small-scale

0.439

High

438646

SC160
Protein SCP160

1

14

High-throughput

0.437

High

647049

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

6

High-throughput

0.437

High

677319

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

706508

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

709627

BMH1
Protein BMH1

1

6

High-throughput

0.437

High

737689

HOG1
Mitogen-activated protein kinase HOG1

1

15

High-throughput

0.437

High

737699

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.437

High

737714

RCK1
Serine/threonine-protein kinase RCK1

1

5

High-throughput

0.437

High

737716

OTU2
OTU domain-containing protein 2

1

1

Small-scale

0.437

High

737718

RPN1
26S proteasome regulatory subunit RPN1

1

5

High-throughput

0.437

High

737724

DHH1
ATP-dependent RNA helicase DHH1

1

8

High-throughput

0.437

High

737734

TM108
Protein TMA108

1

2

High-throughput

0.437

High

737736

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

737739

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

737752

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

737753

COPA
Coatomer subunit alpha

1

5

High-throughput

0.437

High

737756

GIS2
Zinc finger protein GIS2

1

3

High-throughput

0.437

High

737759

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

737761

NUM1
Nuclear migration protein NUM1

1

5

High-throughput

0.437

High

737765

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.437

High

737768

FIN1
Filament protein FIN1

1

1

Small-scale

0.437

High

737769

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.437

High

737771

DHR1
Probable ATP-dependent RNA helicase DHR1

1

10

High-throughput

0.437

High

737778

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

737780

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

8

Small-scale

0.437

High

737781

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

737782

SGO1
Shugoshin

1

1

High-throughput

0.437

High

737783

ESA1
Histone acetyltransferase ESA1

1

1

Small-scale

0.437

High

737785

AP3D
AP-3 complex subunit delta

1

4

High-throughput

0.437

High

737788

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.437

High

737793

DBP10
ATP-dependent RNA helicase DBP10

1

13

High-throughput

0.437

High

737794

CMR1
DNA damage-binding protein CMR1

1

10

High-throughput

0.437

High

386628

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

534234

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.407

High

592097

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.407

High

671597

SCJ1
DnaJ-related protein SCJ1

1

6

High-throughput

0.407

High

737700

HSP78
Heat shock protein 78, mitochondrial

1

9

High-throughput

0.407

High

737703

SPT7
SAGA complex subunit SPT7

1

9

High-throughput

0.407

High

737705

LHS1
Heat shock protein 70 homolog LHS1

1

9

High-throughput

0.407

High

737711

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

1

High-throughput

0.407

High

737729

HSP7E
Heat shock protein SSC3, mitochondrial

1

11

High-throughput

0.407

High

737741

ERJ5
ER-localized J domain-containing protein 5

1

5

High-throughput

0.407

High

737743

JJJ2
J protein JJJ2

1

3

High-throughput

0.407

High

737744

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.407

High

737748

YG1A
Uncharacterized membrane protein YGR016W

1

1

High-throughput

0.407

High

737751

UTP22
U3 small nucleolar RNA-associated protein 22

1

1

High-throughput

0.407

High

737774

RRP5
rRNA biogenesis protein RRP5

1

5

High-throughput

0.407

High

737777

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

16

High-throughput

0.407

High

737787

HFI1
SAGA complex subunit HFI1

1

1

High-throughput

0.407

High

737792

HSP42
Heat shock protein 42

1

3

High-throughput

0.407

High

381952

H4
Histone H4

3

0

High-throughput

0.325

High

676616

SGF29
SAGA complex subunit SGF29

2

0

Small-scale

0.318

High

737773

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.279

Low

737755

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.269

Low

432302

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.261

Low

737738

GLC8
Protein GLC8

1

0

High-throughput

0.249

Low

737764

ESP1
Separin

1

0

High-throughput

0.249

Low

737779

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

737722

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

737725

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

737795

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025