HitPredict

Interactor 1: PSB3 (P49720)
Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)
Gene: PSMB3

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 1083
+	Hs
		656604 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		594535 PSB1_HUMAN (2-205): 1.85e-65: 203: 23.94		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		637692 PSA2_HUMAN (8-205): 1.92e-64: 200: 14.85		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		656235 PSA5_HUMAN (8-203): 6.92e-64: 199: 12.20		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		832050 PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00		HECW2_HUMAN (262-1082): 0: 591: 19.91
+	Hs
		594647 PSB1_HUMAN (2-205): 1.85e-65: 203: 23.94		HECW2_HUMAN (262-1082): 0: 591: 19.91
+	Hs
		831979 PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656590 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656057 PSB8_HUMAN (8-205): 2.05e-67: 209: 22.73		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656703 PSB5_HUMAN (8-197): 1.9e-66: 206: 22.63		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		594511 PSB1_HUMAN (2-205): 1.85e-65: 203: 23.94		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		637675 PSA2_HUMAN (8-205): 1.92e-64: 200: 14.85		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656207 PSA5_HUMAN (8-203): 6.92e-64: 199: 12.20		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656320 PSA5_HUMAN (8-203): 6.92e-64: 199: 12.20		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Sc
		632500 PSB3_YEAST (3-205): 4.69e-66: 203: 54.19		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12
+	Hs
		637712 PSA2_HUMAN (8-205): 1.92e-64: 200: 14.85		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		656264 PSA5_HUMAN (8-203): 6.92e-64: 199: 12.20		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Sc
		619985 PSB6_YEAST (2-205): 1.24e-60: 190: 21.17		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12
+	Sc
		751177 PSB1_YEAST (8-197): 4.54e-56: 178: 22.11		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12