HitPredict

Interactor 1: PSB2 (P49721)
Proteasome subunit beta type-2 (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I)
Gene: PSMB2

Interactor 2: PSME4 (Q14997)
Proteasome activator complex subunit 4 (Proteasome activator PA200)
Gene: PSME4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.900

Property	Details
Experiments	28514442, 33961781, 35271311, 35858375
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BLM10_mid~Proteasome, DUF3437~Proteasome
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 201 Hs			1 1843
+	Hs
		656062 PSB8_HUMAN (2-196): 1.71e-68: 211: 19.49		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		656716 PSB5_HUMAN (2-197): 1.96e-66: 206: 17.86		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		1061392 PSB7_HUMAN (3-199): 1.32e-64: 202: 19.80		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		638132 PSA4_HUMAN (3-198): 5.76e-65: 202: 17.73		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		637689 PSA2_HUMAN (4-197): 1.04e-64: 201: 17.86		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		594529 PSB1_HUMAN (3-198): 2.07e-57: 182: 23.42		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		656600 PSB6_HUMAN (3-188): 2.95e-44: 148: 17.74		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Sc
		604806 PSB4_YEAST (1-193): 1.25e-78: 235: 44.85		BLM10_YEAST (74-831): 0: 722: 16.61
+	Sc
		675424 PSB5_YEAST (2-198): 7.84e-67: 208: 17.77		BLM10_YEAST (74-831): 0: 722: 16.61
+	Sc
		751170 PSB1_YEAST (3-191): 5.03e-57: 180: 20.64		BLM10_YEAST (74-831): 0: 722: 16.61
+	Sc
		625943 PSB2_YEAST (3-184): 1.28e-46: 155: 17.03		BLM10_YEAST (74-831): 0: 722: 16.61