HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	27173435, 15654075
Identification Methods	affinity chromatography technology, tandem affinity purification, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 904 Hs			1 603
+	Xl
		879168 MCM2_XENLA (1-904): 0: 1045: 86.19		PLK1_XENLA (21-603): 0: 590: 80.38
+	Hs
		708406 MCM4_HUMAN (2-885): 0: 847: 28.42		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Xl
		936130 MCM4A_XENLA (9-869): 0: 850: 28.62		PLK1_XENLA (21-603): 0: 590: 80.38
+	Hs
		708584 MCM5_HUMAN (169-902): 0: 768: 29.43		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		627218 MCM3_HUMAN (186-897): 0: 725: 29.20		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		861754 MCM6_HUMAN (186-817): 0: 710: 31.18		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		708848 MCM7_HUMAN (188-886): 0: 707: 27.35		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Xl
		936138 MCM7A_XENLA (188-801): 0: 717: 29.96		PLK1_XENLA (21-603): 0: 590: 80.38
+	Xl
		936129 MC6ZA_XENLA (166-899): 0: 711: 26.98		PLK1_XENLA (21-603): 0: 590: 80.38
+	Hs
		627383 MCM3_HUMAN (186-897): 0: 725: 29.20		KS6B2_HUMAN (53-412): 9.32e-134: 401: 24.66