Protein: UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3)

Gene: UCHL3
Organism: Homo sapiens
Interactions: 133
UniProt ID: P15374

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

507494

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

26

14

Small-scale

0.992

High

583868

NEDD8
Ubiquitin-like protein NEDD8

3

14

Small-scale

0.858

High

583813

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

2

6

Small-scale

0.737

High

583893

CLPB
Mitochondrial disaggregase

4

1

High-throughput

0.697

High

507066

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

14

Small-scale

0.647

High

583856

RAD51
DNA repair protein RAD51 homolog 1

2

1

Small-scale

0.639

High

583892

TRI55
Tripartite motif-containing protein 55

2

19

High-throughput

0.619

High

240658

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.618

High

583888

H2B1N
Histone H2B type 1-N

1

2

Small-scale

0.618

High

583905

UBQL1
Ubiquilin-1

1

8

High-throughput

0.618

High

583880

CSN5
COP9 signalosome complex subunit 5

2

13

Small-scale

0.611

High

583881

TRI63
E3 ubiquitin-protein ligase TRIM63

2

18

High-throughput

0.594

High

259380

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

583825

CTNB1
Catenin beta-1

2

8

Small-scale

0.584

High

583873

Q5U5U6
Epididymis secretory protein Li 50

1

14

Small-scale

0.579

High

583833

YAP1
Transcriptional coactivator YAP1

1

6

Small-scale

0.578

High

583872

RHGBB
Inactive Rho GTPase-activating protein 11B

2

2

High-throughput

0.571

High

583897

RHG35
Rho GTPase-activating protein 35

2

3

High-throughput

0.571

High

559205

XRCC5
X-ray repair cross-complementing protein 5

1

3

Small-scale

0.561

High

583857

FOXM1
Forkhead box protein M1

1

5

Small-scale

0.561

High

583875

CSN6
COP9 signalosome complex subunit 6

1

8

High-throughput

0.536

High

583907

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

14

High-throughput

0.536

High

583867

SMAD1
Mothers against decapentaplegic homolog 1

1

7

Small-scale

0.515

High

583876

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

3

High-throughput

0.515

High

555853

CADH1
Cadherin-1

1

2

Small-scale

0.501

High

573743

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.501

High

583861

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.501

High

583879

PJA1
E3 ubiquitin-protein ligase Praja-1

1

2

High-throughput

0.501

High

583886

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

12

High-throughput

0.501

High

583891

TRI54
Tripartite motif-containing protein 54

1

18

High-throughput

0.501

High

583904

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

10

High-throughput

0.501

High

583909

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

9

High-throughput

0.501

High

583901

POGK
Pogo transposable element with KRAB domain

1

0

High-throughput

0.486

High

583908

NSG2
Neuronal vesicle trafficking-associated protein 2

1

0

High-throughput

0.486

High

571862

TRI27
Zinc finger protein RFP

1

3

High-throughput

0.481

High

583871

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

13

High-throughput

0.481

High

583870

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.480

High

123042

DX39A
ATP-dependent RNA helicase DDX39A

1

6

Small-scale

0.479

High

140729

NOP56
Nucleolar protein 56

1

3

Small-scale

0.479

High

141310

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

Small-scale

0.479

High

169925

AURKA
Aurora kinase A

1

5

Small-scale

0.479

High

347508

BAG3
BAG family molecular chaperone regulator 3

1

4

High-throughput

0.479

High

348344

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

Small-scale

0.479

High

365286

PGK1
Phosphoglycerate kinase 1

1

2

Small-scale

0.479

High

385232

K2C6A
Keratin, type II cytoskeletal 6A

1

9

Small-scale

0.479

High

436785

K1C18
Keratin, type I cytoskeletal 18

1

8

Small-scale

0.479

High

445716

ENOA
Alpha-enolase

1

4

Small-scale

0.479

High

461110

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.479

High

474450

VIME
Vimentin

1

10

Small-scale

0.479

High

536429

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

541809

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.479

High

557828

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

573310

ENPL
Endoplasmin

1

7

Small-scale

0.479

High

576271

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

6

Small-scale

0.479

High

576703

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

4

Small-scale

0.479

High

583814

DDX5
Probable ATP-dependent RNA helicase DDX5

1

6

Small-scale

0.479

High

583815

LMNB1
Lamin-B1

1

8

Small-scale

0.479

High

583817

RL13
Large ribosomal subunit protein eL13

1

2

Small-scale

0.479

High

583818

EF1G
Elongation factor 1-gamma

1

6

Small-scale

0.479

High

583820

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

3

Small-scale

0.479

High

583823

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

3

Small-scale

0.479

High

583826

AHR
Aryl hydrocarbon receptor

1

3

Small-scale

0.479

High

583828

IF4A3
Eukaryotic initiation factor 4A-III

1

9

Small-scale

0.479

High

583829

TCPZ
T-complex protein 1 subunit zeta

1

7

Small-scale

0.479

High

583830

MDHM
Malate dehydrogenase, mitochondrial

1

5

Small-scale

0.479

High

583832

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.479

High

583834

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

583835

FAS
Fatty acid synthase

1

2

Small-scale

0.479

High

583836

TCPG
T-complex protein 1 subunit gamma

1

7

Small-scale

0.479

High

583838

TCPD
T-complex protein 1 subunit delta

1

8

Small-scale

0.479

High

583839

FXR1
RNA-binding protein FXR1

1

3

Small-scale

0.479

High

583840

RAB7A
Ras-related protein Rab-7a

1

6

Small-scale

0.479

High

583842

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

3

Small-scale

0.479

High

583843

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

6

Small-scale

0.479

High

583844

IF4A1
Eukaryotic initiation factor 4A-I

1

7

Small-scale

0.479

High

583845

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

Small-scale

0.479

High

583846

RS15A
Small ribosomal subunit protein uS8

1

1

Small-scale

0.479

High

583847

ACTA
Actin, aortic smooth muscle

1

10

Small-scale

0.479

High

583848

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

3

High-throughput

0.479

High

583849

RL10A
Large ribosomal subunit protein uL1

1

3

Small-scale

0.479

High

583850

ACTG
Actin, cytoplasmic 2

1

11

Small-scale

0.479

High

583851

TBA4A
Tubulin alpha-4A chain

1

10

Small-scale

0.479

High

583852

TBB4B
Tubulin beta-4B chain

1

11

Small-scale

0.479

High

583854

PRKDC
DNA-dependent protein kinase catalytic subunit

1

2

Small-scale

0.479

High

583855

CLH1
Clathrin heavy chain 1

1

1

Small-scale

0.479

High

583858

SSRP1
FACT complex subunit SSRP1

1

5

Small-scale

0.479

High

583859

ILF2
Interleukin enhancer-binding factor 2

1

3

Small-scale

0.479

High

583860

ILF3
Interleukin enhancer-binding factor 3

1

5

Small-scale

0.479

High

583863

DX39B
Spliceosome RNA helicase DDX39B

1

8

Small-scale

0.479

High

583864

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

10

Small-scale

0.479

High

583866

NONO
Non-POU domain-containing octamer-binding protein

1

7

Small-scale

0.479

High

583874

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

583877

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

7

Small-scale

0.479

High

583878

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

583885

AURKB
Aurora kinase B

1

5

Small-scale

0.479

High

583887

TCPH
T-complex protein 1 subunit eta

1

8

Small-scale

0.479

High

583889

TBB6
Tubulin beta-6 chain

1

11

Small-scale

0.479

High

583894

RAB1B
Ras-related protein Rab-1B

1

4

Small-scale

0.479

High

583896

DDX21
Nucleolar RNA helicase 2

1

7

Small-scale

0.479

High

583902

LIMA1
LIM domain and actin-binding protein 1

1

4

Small-scale

0.479

High

583906

E41L3
Band 4.1-like protein 3

1

3

Small-scale

0.479

High

583910

SRPRB
Signal recognition particle receptor subunit beta

1

3

Small-scale

0.479

High

109362

G5E9A7
DM1 locus, WD repeat containing

1

4

High-throughput

0.470

High

122464

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

Small-scale

0.458

High

339418

ACSL3
Fatty acid CoA ligase Acsl3

1

0

Small-scale

0.458

High

417248

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

Small-scale

0.458

High

583824

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

583827

ZEB1
Zinc finger E-box-binding homeobox 1

1

0

Small-scale

0.458

High

583869

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

Small-scale

0.458

High

583882

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

583900

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

Small-scale

0.458

High

572738

PA2GA
Phospholipase A2, membrane associated

1

2

Small-scale

0.457

High

583853

RAE1L
mRNA export factor RAE1

1

3

High-throughput

0.445

High

583884

OTUB1
Ubiquitin thioesterase OTUB1

1

2

High-throughput

0.445

High

583899

DDX28
Probable ATP-dependent RNA helicase DDX28

1

7

High-throughput

0.445

High

583911

SNX8
Sorting nexin-8

1

4

High-throughput

0.445

High

552111

ADT3
ADP/ATP translocase 3

1

1

Small-scale

0.437

High

583822

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

3

Small-scale

0.437

High

583831

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

3

Small-scale

0.437

High

583841

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

3

Small-scale

0.437

High

583898

HELLS
Lymphoid-specific helicase

1

1

Small-scale

0.437

High

583903

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

1

Small-scale

0.437

High

583819

CYTD
Cystatin-D

1

0

High-throughput

0.426

High

583883

CPNE2
Copine-2

1

0

High-throughput

0.426

High

583895

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

583837

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

345146

ZMYM6
Zinc finger MYM-type protein 6

3

0

High-throughput

0.347

High

583865

AT7L3
Ataxin-7-like protein 3

1

0

High-throughput

0.282

High

583816

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

1

0

Small-scale

0.249

Low

583821

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

Small-scale

0.249

Low

583890

SFXN3
Sideroflexin-3

1

0

Small-scale

0.249

Low

583862

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025