HitPredict

Interactor 1: LEP (P41159)
Leptin (Obese protein) (Obesity factor)
Gene: LEP

Interactor 2: LEPR (P48357)
Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295)
Gene: LEPR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.73 1.00 0.857

The method score is based on:

Property Details
Experiments 33961781, 9786864, 22405007
Identification Methods affinity chromatography technology, cross-linking study, molecular sieving, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Lep_receptor_Ig~Leptin, Leptin~ObR_Ig
Common GO terms GO:0001525 - angiogenesis
GO:0005576 - extracellular region
GO:0006112 - energy reserve metabolic process
GO:0006909 - phagocytosis
GO:0008203 - cholesterol metabolic process
and 10 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 167
Hs

1 1165
+ Mm

Service provided by Combinatics, Japan

Last updated: 11Aug2025