Interactor 1: LEP (P41160)
Leptin (Obesity factor)
Gene: LEP
Interactor 2: LEPR (P48356)
Leptin receptor (LEP-R) (B219) (OB receptor) (OB-R) (CD antigen CD295)
Gene: LEPR
Species: Mus musculus
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.55 | 1.00 | 0.742 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 24882746 |
| Identification Methods | x ray scattering, field flow fractionation, static light scattering, isothermal titration calorimetry, transmission electron microscopy, molecular sieving |
| Interaction Type | direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Lep_receptor_Ig~Leptin, Leptin~ObR_Ig |
| Common GO terms | GO:0001525 - angiogenesis GO:0005576 - extracellular region GO:0006909 - phagocytosis GO:0008203 - cholesterol metabolic process GO:0010507 - negative regulation of autophagy and 9 others more... |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
