HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: H2A1H (Q96KK5)
Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s)
Gene: H2AC12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25963833
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 128
+	Hs
		832523 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A2A_HUMAN (1-128): 4.68e-67: 200: 98.44
+	Hs
		832672 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1J_HUMAN (1-128): 2.71e-67: 200: 99.22
+	Hs
		391599 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1B_HUMAN (1-128): 1.07e-66: 199: 98.44
+	Hs
		470300 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1_HUMAN (1-128): 6.72e-67: 199: 100.00
+	Hs
		594831 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1D_HUMAN (1-128): 7.84e-67: 199: 99.22
+	Hs
		832548 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A3_HUMAN (1-128): 7.5e-67: 199: 97.66
+	Hs
		832623 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1C_HUMAN (1-128): 6.95e-67: 199: 98.44
+	Hs
		832655 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1A_HUMAN (1-125): 1.51e-66: 199: 95.20
+	Hs
		832567 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A2B_HUMAN (1-128): 1.07e-65: 196: 95.31
+	Hs
		832496 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A2C_HUMAN (1-124): 8.56e-65: 194: 98.39
+	Hs
		832683 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2AJ_HUMAN (1-124): 1.08e-64: 194: 97.58
+	Hs
		555351 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2AX_HUMAN (1-124): 2.04e-63: 191: 94.36
+	Hs
		708464 MCM4_HUMAN (2-885): 0: 847: 28.42		H2A2A_HUMAN (1-128): 4.68e-67: 200: 98.44
+	Hs
		391569 MCM4_HUMAN (2-885): 0: 847: 28.42		H2A1B_HUMAN (1-128): 1.07e-66: 199: 98.44
+	Hs
		555318 MCM4_HUMAN (2-885): 0: 847: 28.42		H2AX_HUMAN (1-124): 2.04e-63: 191: 94.36
+	Sc
		392333 MCM2_YEAST (11-821): 0: 819: 46.70		H2A2_YEAST (16-127): 1.11e-58: 179: 81.25
+	Sc
		392073 MCM2_YEAST (11-821): 0: 819: 46.70		H2A1_YEAST (16-127): 3.38e-53: 165: 81.25
+	Hs
		391570 MCM5_HUMAN (169-902): 0: 768: 29.43		H2A1B_HUMAN (1-128): 1.07e-66: 199: 98.44
+	Hs
		470283 MCM5_HUMAN (169-902): 0: 768: 29.43		H2A1_HUMAN (1-128): 6.72e-67: 199: 100.00
+	Hs
		555319 MCM5_HUMAN (169-902): 0: 768: 29.43		H2AX_HUMAN (1-124): 2.04e-63: 191: 94.36