Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: PSF3 (Q9BRX5)
DNA replication complex GINS protein PSF3 (GINS complex subunit 3)
Gene: GINS3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.849

The method score is based on:

Property Details
Experiments 26186194, 33961781, 19805216
Identification Methods affinity chromatography technology, bimolecular fluorescence complementation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~Sld5, MCM_N~Sld5
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006268 - DNA unwinding involved in DNA replication
GO:0071162 - CMG complex
GO:1902975 - mitotic DNA replication initiation
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 904
Hs

1 216
+ Dm
+ Hs
+ Hs
+ Dm
+ Sc
+ Dm
+ Sc
+ Dm
+ Sc

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Last updated: 15 Jul 2024