HitPredict

Interactor 1: NUMB (P49757)
Protein numb homolog (h-Numb) (Protein S171)
Gene: NUMB

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.635

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 651 Hs			1 247
+	Hs
		833567 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		833585 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Rn
		935724 Q3MUI1_RAT (1-651): 2.15e-78: 262: 83.13		1433F_RAT (1-246): 1.51e-136: 385: 86.99
+	Hs
		683205 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		833573 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		646726 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		683906 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		910216 NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		905324 NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		982672 NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		909875 ANS1A_HUMAN (8-244): 1.9e-39: 158: 18.49		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		904939 ANS1A_HUMAN (8-244): 1.9e-39: 158: 18.49		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		982351 ANS1A_HUMAN (8-244): 1.9e-39: 158: 18.49		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		683860 NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		927720 NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		647430 NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		683592 ANS1A_HUMAN (8-244): 1.9e-39: 158: 18.49		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		927366 ANS1A_HUMAN (8-244): 1.9e-39: 158: 18.49		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		647160 ANS1A_HUMAN (8-244): 1.9e-39: 158: 18.49		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		684244 ANS1A_HUMAN (8-244): 1.9e-39: 158: 18.49		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16