HitPredict

Interactor 1: NUMB (P49757)
Protein numb homolog (h-Numb) (Protein S171)
Gene: NUMB

Interactor 2: SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)
Gene: SIAH1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	11752454, 21988832
Identification Methods	two hybrid, pull down, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 651 Hs			1 282
+	Hs
		1216743 NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55		SIAH1_HUMAN (1-282): 7.29e-121: 348: 100.00
+	Hs
		269166 DAB1_HUMAN (31-622): 1.27e-34: 141: 15.66		SIAH1_HUMAN (1-282): 7.29e-121: 348: 100.00
+	Mm
		896598 DAB1_MOUSE (31-622): 6.85e-35: 141: 15.66		SIA1A_MOUSE (1-282): 2.65e-120: 347: 99.65
+	Hs
		129608 NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55		TRAF5_HUMAN (25-148): 2.59e-26: 109: 19.55
+	Hs
		253600 CAPON_HUMAN (8-286): 2.51e-35: 141: 17.11		TRAF4_HUMAN (25-151): 5.73e-26: 107: 20.00