Protein: PSME2
Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta)

Gene: PSME2
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q9UL46

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008537 - proteasome activator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1054667

PSME1
Proteasome activator complex subunit 1

17

4

Small-scale

0.985

High

700546

PSB9
Proteasome subunit beta type-9

5

20

Small-scale

0.927

High

1404128

PSB7
Proteasome subunit beta type-7

5

20

Small-scale

0.919

High

1461448

PSME2
Proteasome activator complex subunit 2

4

4

Small-scale

0.902

High

681074

PSA1
Proteasome subunit alpha type-1

4

16

High-throughput

0.895

High

887737

PSB2
Proteasome subunit beta type-2

4

20

Small-scale

0.892

High

633820

PSB1
Proteasome subunit beta type-1

3

20

High-throughput

0.871

High

681238

PSA2
Proteasome subunit alpha type-2

3

18

Small-scale

0.861

High

700970

PSB4
Proteasome subunit beta type-4

3

20

High-throughput

0.861

High

700755

PSA5
Proteasome subunit alpha type-5

3

15

High-throughput

0.855

High

887606

PSB3
Proteasome subunit beta type-3

2

20

High-throughput

0.811

High

700486

PSB8
Proteasome subunit beta type-8

2

20

Small-scale

0.789

High

681741

PSA4
Proteasome subunit alpha type-4

2

19

Small-scale

0.754

High

140482

SDCB1
Syntenin-1

5

1

High-throughput

0.716

High

165432

PSA7
Proteasome subunit alpha type-7

1

16

High-throughput

0.691

High

564548

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.643

High

138335

PSDE
26S proteasome non-ATPase regulatory subunit 14

3

2

Small-scale

0.640

High

1400524

CDK15
Cyclin-dependent kinase 15

2

1

High-throughput

0.628

High

1461452

FBX7
F-box only protein 7

2

2

High-throughput

0.628

High

681547

PSA3
Proteasome subunit alpha type-3

1

14

Small-scale

0.618

High

701092

PSB6
Proteasome subunit beta type-6

1

20

Small-scale

0.618

High

822170

PSB10
Proteasome subunit beta type-10

1

20

Small-scale

0.618

High

1136616

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

2

Small-scale

0.611

High

822206

CTRL
Chymotrypsin-like protease CTRL-1

3

1

High-throughput

0.609

High

1348573

LNX1
E3 ubiquitin-protein ligase LNX

2

3

High-throughput

0.606

High

1415396

DUS23
Dual specificity protein phosphatase 23

2

5

High-throughput

0.606

High

387917

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.602

High

1248502

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.602

High

1350099

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.602

High

833699

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.586

High

1420027

UBL5
Ubiquitin-like protein 5

2

0

High-throughput

0.580

High

114611

H0YKT8
Proteasome subunit beta

1

19

High-throughput

0.575

High

1417853

RNF26
E3 ubiquitin-protein ligase RNF26

2

2

High-throughput

0.574

High

277968

SH3L1
Adapter SH3BGRL

2

0

High-throughput

0.547

High

954758

SEM1
26S proteasome complex subunit SEM1

1

2

Small-scale

0.536

High

958586

TM258
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

1

1

High-throughput

0.536

High

1161257

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.536

High

1381317

PSMG2
Proteasome assembly chaperone 2

1

2

High-throughput

0.536

High

1406657

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.536

High

581739

MYOD1
Myoblast determination protein 1

1

0

High-throughput

0.518

High

361375

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

602851

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

943159

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

1023911

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

1453206

GPC5D
G-protein coupled receptor family C group 5 member D

1

0

High-throughput

0.513

High

423436

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

710559

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.494

High

870809

CXA8
Gap junction alpha-8 protein

1

3

High-throughput

0.489

High

1461456

CXA3
Gap junction alpha-3 protein

1

3

High-throughput

0.489

High

132371

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

132776

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

1

Small-scale

0.479

High

243266

PRKN
E3 ubiquitin-protein ligase parkin

1

2

Small-scale

0.479

High

260599

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

316146

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

347994

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

530556

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.479

High

538098

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

599231

IL7RA
Interleukin-7 receptor subunit alpha

1

1

High-throughput

0.479

High

610504

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.479

High

651460

CBL
E3 ubiquitin-protein ligase CBL

1

2

High-throughput

0.479

High

685773

U2AF2
Splicing factor U2AF 65 kDa subunit

1

4

High-throughput

0.479

High

773800

ACTN2
Alpha-actinin-2

1

2

High-throughput

0.479

High

831633

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

888387

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

965322

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

1122584

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1138745

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1219001

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

1229760

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1256052

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1280590

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

1289710

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1353301

PARD3
Partitioning defective 3 homolog

1

3

Small-scale

0.479

High

1364300

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

1448240

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

Small-scale

0.479

High

1451312

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

1459275

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1461449

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

1461454

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

4

Small-scale

0.479

High

157975

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

218946

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

596899

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

718853

CCND2
G1/S-specific cyclin-D2

1

0

Small-scale

0.458

High

985062

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1128863

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1161084

FSCN1
Fascin

1

0

High-throughput

0.458

High

1241843

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

1308240

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.458

High

1383277

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1461455

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.458

High

1227686

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.445

High

1420761

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

412793

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

1461102

GPTC8
G patch domain-containing protein 8

1

3

High-throughput

0.437

High

1461451

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

598792

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

1447612

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

1461450

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

887319

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

97087

E9PMD8
Proteasome 26S subunit, ATPase 3

1

6

High-throughput

0.407

High

280968

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

608385

EGLN
Endoglin

1

0

High-throughput

0.279

Low

1037908

HEN1
Helix-loop-helix protein 1

1

0

High-throughput

0.251

Low

1104161

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1461453

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025