HitPredict

Interactor 1: NUMB (P49757)
Protein numb homolog (h-Numb) (Protein S171)
Gene: NUMB

Interactor 2: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	26186194, 28514442, 33961781, 24189400, 23211419
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0031410 - cytoplasmic vesicle GO:0098978 - glutamatergic synapse GO:1903077 - negative regulation of protein localization to plasma membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 651 Hs			1 435
+	Rn
		950916 Q3MUI1_RAT (1-651): 2.15e-78: 262: 83.13		AP2M1_RAT (1-435): 1.03e-178: 507: 100.00
+	Hs
		1287523 GULP1_HUMAN (4-301): 1.98e-53: 187: 20.46		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		253596 CAPON_HUMAN (8-286): 2.51e-35: 141: 17.11		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		957208 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Ce
		283750 CED6_CAEEL (7-402): 5.6e-36: 143: 14.85		AP2M_CAEEL (1-435): 3.73e-172: 491: 80.95
+	Mm
		1206658 ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75		AP3M2_MOUSE (1-434): 4.8e-118: 352: 24.89