Protein: MED18
Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (p28b)

Gene: MED18
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q9BUE0

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1312761

MED20
Mediator of RNA polymerase II transcription subunit 20

12

2

Small-scale

0.985

High

1312766

MED17
Mediator of RNA polymerase II transcription subunit 17

7

1

Small-scale

0.967

High

1291842

MED8
Mediator of RNA polymerase II transcription subunit 8

5

1

High-throughput

0.932

High

1312770

MED11
Mediator of RNA polymerase II transcription subunit 11

4

1

High-throughput

0.909

High

1074725

MED22
Mediator of RNA polymerase II transcription subunit 22

6

0

Small-scale

0.902

High

625018

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

0

High-throughput

0.827

High

1312292

MED10
Mediator of RNA polymerase II transcription subunit 10

10

1

Small-scale

0.759

High

1312768

MED29
Mediator of RNA polymerase II transcription subunit 29

9

1

Small-scale

0.756

High

1312765

MED4
Mediator of RNA polymerase II transcription subunit 4

7

1

Small-scale

0.751

High

1274340

MED12
Mediator of RNA polymerase II transcription subunit 12

7

1

Small-scale

0.751

High

826346

CDK8
Cyclin-dependent kinase 8

7

3

High-throughput

0.750

High

1312771

MED13
Mediator of RNA polymerase II transcription subunit 13

6

2

Small-scale

0.736

High

48719

MED19
Mediator of RNA polymerase II transcription subunit 19

10

0

Small-scale

0.726

High

206646

MED7
Mediator of RNA polymerase II transcription subunit 7

5

1

High-throughput

0.722

High

225415

MED14
Mediator of RNA polymerase II transcription subunit 14

5

2

High-throughput

0.722

High

1158920

MED27
Mediator of RNA polymerase II transcription subunit 27

5

1

High-throughput

0.722

High

1293698

MED30
Mediator of RNA polymerase II transcription subunit 30

5

1

High-throughput

0.722

High

1312775

MED31
Mediator of RNA polymerase II transcription subunit 31

5

1

High-throughput

0.722

High

1312767

MED9
Mediator of RNA polymerase II transcription subunit 9

7

0

Small-scale

0.720

High

270527

MED6
Mediator of RNA polymerase II transcription subunit 6

5

2

Small-scale

0.718

High

1312773

MED23
Mediator of RNA polymerase II transcription subunit 23

5

1

High-throughput

0.718

High

1312774

MED16
Mediator of RNA polymerase II transcription subunit 16

5

1

High-throughput

0.718

High

624500

CCNC
Cyclin-C

5

1

High-throughput

0.714

High

1076197

MED1
Mediator of RNA polymerase II transcription subunit 1

6

0

Small-scale

0.709

High

313463

MED26
Mediator of RNA polymerase II transcription subunit 26

6

0

High-throughput

0.707

High

1037091

MED21
Mediator of RNA polymerase II transcription subunit 21

6

0

Small-scale

0.706

High

1312760

MED28
Mediator of RNA polymerase II transcription subunit 28

6

0

High-throughput

0.705

High

1301088

MED15
Mediator of RNA polymerase II transcription subunit 15

4

1

High-throughput

0.694

High

1312759

CDK19
Cyclin-dependent kinase 19

4

3

High-throughput

0.694

High

265359

MED24
Mediator of RNA polymerase II transcription subunit 24

5

0

High-throughput

0.688

High

1174775

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

2

High-throughput

0.675

High

1312764

TRI39
E3 ubiquitin-protein ligase TRIM39

4

0

High-throughput

0.670

High

1206157

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

3

1

High-throughput

0.667

High

1220199

HOMEZ
Homeobox and leucine zipper protein Homez

3

0

High-throughput

0.639

High

177719

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

583567

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.602

High

583784

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.602

High

913946

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.602

High

1221354

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.602

High

1312758

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

Small-scale

0.586

High

1174959

MED25
Mediator of RNA polymerase II transcription subunit 25

2

0

High-throughput

0.585

High

1144467

KFA
Kynurenine formamidase

2

0

High-throughput

0.580

High

1040948

MTMR3
Myotubularin-related protein 3

2

1

High-throughput

0.574

High

1312769

MTMR4
Myotubularin-related protein 4

2

1

High-throughput

0.574

High

1038920

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

0

High-throughput

0.549

High

1038677

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.536

High

1270416

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.536

High

676986

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

738877

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.513

High

843879

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.513

High

854356

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.513

High

854460

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.513

High

1312762

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.513

High

266421

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

487731

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

1269499

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

244875

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

374798

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

553590

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

1019114

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1044111

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.458

High

1173760

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1251007

SNIP1
Smad nuclear-interacting protein 1

1

0

Small-scale

0.458

High

1306529

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

73040

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

3

High-throughput

0.445

High

91309

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1301373

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

509267

G6PD
Glucose-6-phosphate 1-dehydrogenase

2

0

High-throughput

0.328

High

1298383

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.316

High

1121797

ANR39
Ankyrin repeat domain-containing protein 39

1

0

High-throughput

0.279

Low

1135309

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

High-throughput

0.279

Low

1190186

CLAP1
CLIP-associating protein 1

1

0

High-throughput

0.279

Low

1262659

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.279

Low

1299718

CMA1A
Ciliary microtubule associated protein 1A

1

0

High-throughput

0.279

Low

1310086

REEP2
Receptor expression-enhancing protein 2

1

0

High-throughput

0.279

Low

1312763

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.279

Low

1312772

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.279

Low

882533

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024