HitPredict

Interactor 1: NUMB (P49757)
Protein numb homolog (h-Numb) (Protein S171)
Gene: NUMB

Interactor 2: REPS1 (Q96D71)
RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)
Gene: REPS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23211419
Identification Methods	pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 651 Hs			1 796
+	Hs
		833668 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		EP15R_HUMAN (8-735): 2e-72: 256: 13.93
+	Hs
		957209 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		REPS1_HUMAN (1-796): 2.33e-108: 351: 100.00
+	Hs
		787868 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		EPS15_HUMAN (4-782): 1.98e-17: 89.3: 10.12
+	Dm
		91154 NUMB_DROME (16-540): 1.63e-40: 157: 36.14		E3CTP7_DROME (1-695): 1.93e-74: 260: 11.95
+	Mm
		788008 NUMB_MOUSE (1-651): 8.07e-101: 323: 92.96		EPS15_MOUSE (4-782): 2.51e-16: 85.8: 10.27
+	Ce
		60776 A5JYR4_CAEEL (10-460): 6.7e-37: 146: 14.32		Q8MYM6_CAEEL (255-552): 5.22e-39: 151: 22.54
+	Dm
		561284 NUMB_DROME (16-540): 1.63e-40: 157: 36.14		Q8T8W3_DROME (269-370): 7.19e-34: 139: 38.24
+	Dm
		112569 NUMB_DROME (16-540): 1.63e-40: 157: 36.14		M9ND00_DROME (1-272): 5.39e-25: 113: 9.23
+	Mm
		1206702 ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75		ITSN1_MOUSE (3-100): 1.25e-15: 83.9: 19.39
+	Mm
		1141842 ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75		EP15R_MOUSE (4-236): 2.2e-12: 73.1: 12.55
+	Ce
		60778 A5JYR4_CAEEL (10-460): 6.7e-37: 146: 14.32		Q8WSP1_CAEEL (4-110): 1.59e-19: 95.4: 15.89
+	Ce
		1353620 NUMB1_CAEEL (1-539): 6.75e-43: 165: 28.52		Q9U2T9_CAEEL (1-119): 4.74e-11: 68.9: 16.41
+	Mm
		787999 DAB2_MOUSE (5-598): 3.19e-36: 147: 13.49		EPS15_MOUSE (4-782): 2.51e-16: 85.8: 10.27
+	Hs
		269148 DAB1_HUMAN (31-622): 1.27e-34: 141: 15.66		ITSN1_HUMAN (1-115): 1.23e-17: 90.4: 16.52
+	Mm
		957157 DAB2_MOUSE (5-598): 3.19e-36: 147: 13.49		ITSN1_MOUSE (3-100): 1.25e-15: 83.9: 19.39
+	Hs
		957186 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		ITSN1_HUMAN (1-115): 1.23e-17: 90.4: 16.52
+	Hs
		787894 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		EPS15_HUMAN (4-782): 1.98e-17: 89.3: 10.12
+	Mm
		957141 DAB2_MOUSE (5-598): 3.19e-36: 147: 13.49		EP15R_MOUSE (4-236): 2.2e-12: 73.1: 12.55
+	Ce
		60780 A5JYR4_CAEEL (10-460): 6.7e-37: 146: 14.32		Q9U2T9_CAEEL (1-119): 4.74e-11: 68.9: 16.41
+	Ce
		283754 CED6_CAEEL (7-402): 5.6e-36: 143: 14.85		Q9U2T9_CAEEL (1-119): 4.74e-11: 68.9: 16.41