HitPredict

Interactor 1: CLK1 (P49759)
Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
Gene: CLK1

Interactor 2: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	31064840, 32296183, 8798720, 12565863, 34133714, 34316707, unassigned1304
Identification Methods	pull down, affinity chromatography technology, two hybrid, enzymatic study, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0043484 - regulation of RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 484 Hs			1 248
+	Hs
		833727 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		833728 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		833721 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		1028829 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		1029103 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		993837 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		992944 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		833875 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		833711 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		833871 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		833742 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		833870 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		834026 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		516362 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		516416 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		516417 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		833865 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		834022 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		625466 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		833887 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22