Protein: KDM5C
Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C)

Gene: KDM5C
Organism: Homo sapiens
Interactions: 120
UniProt ID: P41229

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

833746

H32
Histone H3.2

3

20

Small-scale

0.845

High

833731

TIF1B
Transcription intermediary factor 1-beta

2

3

High-throughput

0.776

High

833789

MO4L1
Mortality factor 4-like protein 1

2

5

High-throughput

0.776

High

833793

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

2

7

High-throughput

0.754

High

833724

EWS
RNA-binding protein EWS

1

3

High-throughput

0.691

High

833730

CBX3
Chromobox protein homolog 3

1

4

Small-scale

0.691

High

833733

HDAC1
Histone deacetylase 1

1

14

Small-scale

0.691

High

833736

MO4L2
Mortality factor 4-like protein 2

1

5

High-throughput

0.691

High

833763

HDAC2
Histone deacetylase 2

1

14

Small-scale

0.691

High

833775

BRD8
Bromodomain-containing protein 8

1

12

High-throughput

0.691

High

833783

ASH1L
Histone-lysine N-methyltransferase ASH1L

1

15

High-throughput

0.691

High

833754

SCML4
Sex comb on midleg-like protein 4

3

2

High-throughput

0.667

High

833795

LHX6
LIM/homeobox protein Lhx6

3

7

High-throughput

0.667

High

340560

CNOT4
CCR4-NOT transcription complex subunit 4

1

2

Small-scale

0.647

High

833772

IER2
Immediate early response gene 2 protein

3

0

High-throughput

0.638

High

833716

MAX
Protein max

2

3

Small-scale

0.628

High

833732

SKP2
S-phase kinase-associated protein 2

2

3

High-throughput

0.628

High

833743

DEFI8
Differentially expressed in FDCP 8 homolog

2

1

High-throughput

0.628

High

833760

SSH3
Protein phosphatase Slingshot homolog 3

2

1

High-throughput

0.628

High

833797

TRI35
E3 ubiquitin-protein ligase TRIM35

2

6

High-throughput

0.628

High

833752

MGAP
MAX gene-associated protein

2

4

Small-scale

0.618

High

259570

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.618

High

833709

KDM5C
Lysine-specific demethylase 5C

1

14

Small-scale

0.618

High

833715

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

14

Small-scale

0.618

High

833749

PB1
Protein polybromo-1

1

16

Small-scale

0.618

High

833759

SMRC2
SWI/SNF complex subunit SMARCC2

1

17

Small-scale

0.618

High

833796

TRI33
E3 ubiquitin-protein ligase TRIM33

1

5

High-throughput

0.618

High

833710

RHG25
Rho GTPase-activating protein 25

3

3

High-throughput

0.609

High

282681

E2F6
Transcription factor E2F6

2

0

Small-scale

0.602

High

350690

NOE2
Noelin-2

2

0

High-throughput

0.602

High

833774

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

833741

SNPC4
snRNA-activating protein complex subunit 4

2

1

High-throughput

0.601

High

833785

ING3
Inhibitor of growth protein 3

2

1

High-throughput

0.601

High

833734

CUL3
Cullin-3

2

7

High-throughput

0.584

High

833765

TRI11
E3 ubiquitin-protein ligase TRIM11

1

5

Small-scale

0.578

High

833729

REST
RE1-silencing transcription factor

1

1

Small-scale

0.565

High

64856

RCCD1
RCC1 domain-containing protein 1

1

1

High-throughput

0.536

High

172535

XPO1
Exportin-1

1

9

High-throughput

0.536

High

211628

ZNHI1
Zinc finger HIT domain-containing protein 1

1

1

High-throughput

0.536

High

278262

NCOR1
Nuclear receptor corepressor 1

1

7

Small-scale

0.536

High

288274

SPAG6
Sperm-associated antigen 6

1

1

High-throughput

0.536

High

318455

TOX4
TOX high mobility group box family member 4

1

7

High-throughput

0.536

High

507105

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

2

High-throughput

0.536

High

833718

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.536

High

833723

SET
Protein SET

1

5

High-throughput

0.536

High

833725

MBTD1
MBT domain-containing protein 1

1

3

High-throughput

0.536

High

833726

RING1
E3 ubiquitin-protein ligase RING1

1

9

Small-scale

0.536

High

833740

EPC2
Enhancer of polycomb homolog 2

1

2

High-throughput

0.536

High

833751

PALB2
Partner and localizer of BRCA2

1

1

High-throughput

0.536

High

833753

ZN687
Zinc finger protein 687

1

2

High-throughput

0.536

High

833755

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

High-throughput

0.536

High

833762

ZN592
Zinc finger protein 592

1

2

High-throughput

0.536

High

833769

EP400
E1A-binding protein p400

1

15

High-throughput

0.536

High

833770

RING2
E3 ubiquitin-protein ligase RING2

1

10

Small-scale

0.536

High

833773

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

833776

EPC1
Enhancer of polycomb homolog 1

1

1

High-throughput

0.536

High

833777

TSYL2
Testis-specific Y-encoded-like protein 2

1

5

High-throughput

0.536

High

833781

ZN532
Zinc finger protein 532

1

2

High-throughput

0.536

High

833782

TRI39
E3 ubiquitin-protein ligase TRIM39

1

5

High-throughput

0.536

High

833784

MRGBP
MRG/MORF4L-binding protein

1

1

High-throughput

0.536

High

833787

FOXJ2
Forkhead box protein J2

1

7

High-throughput

0.536

High

833788

MBD2
Methyl-CpG-binding domain protein 2

1

2

High-throughput

0.536

High

833802

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.536

High

833805

TF3C3
General transcription factor 3C polypeptide 3

1

2

High-throughput

0.536

High

712150

TKT
Transketolase

1

0

High-throughput

0.513

High

777419

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.513

High

833712

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

0

High-throughput

0.513

High

833714

TUB
Tubby protein homolog

1

0

High-throughput

0.513

High

833728

TF3C1
General transcription factor 3C polypeptide 1

1

0

High-throughput

0.513

High

833756

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

833761

TF3C2
General transcription factor 3C polypeptide 2

1

0

High-throughput

0.513

High

833764

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

833766

ZN764
Zinc finger protein 764

1

0

High-throughput

0.513

High

833767

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.513

High

833771

CENPK
Centromere protein K

1

0

High-throughput

0.513

High

833778

TXNIP
Thioredoxin-interacting protein

1

0

High-throughput

0.513

High

833780

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.513

High

833792

FBX10
F-box only protein 10

1

0

High-throughput

0.513

High

833794

SUFU
Suppressor of fused homolog

1

0

High-throughput

0.513

High

833798

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.513

High

833803

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

833804

TF3C5
General transcription factor 3C polypeptide 5

1

0

High-throughput

0.513

High

833806

MOFA1
MORF4 family-associated protein 1

1

0

High-throughput

0.513

High

278820

PEX14
Peroxisomal membrane protein PEX14

1

1

High-throughput

0.501

High

833717

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

833768

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

2

Small-scale

0.500

High

833801

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

3

Small-scale

0.500

High

302151

NEBL
Nebulette

1

3

High-throughput

0.489

High

833719

TBA1B
Tubulin alpha-1B chain

1

4

High-throughput

0.489

High

833735

TFDP1
Transcription factor Dp-1

1

0

Small-scale

0.479

High

413340

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

550906

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.479

High

833713

MXI1
Max-interacting protein 1

1

5

Small-scale

0.479

High

833720

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.479

High

833721

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.479

High

833744

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

833747

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

833748

SLN11
Schlafen family member 11

1

2

High-throughput

0.479

High

833757

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

833758

NUP43
Nucleoporin Nup43

1

19

High-throughput

0.479

High

833791

XPO7
Exportin-7

1

8

High-throughput

0.479

High

320634

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

833786

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

833790

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

95971

E7EU96
Casein kinase II subunit alpha

1

1

High-throughput

0.445

High

833745

E400N
Putative EP400-like protein

1

1

High-throughput

0.407

High

833799

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.407

High

833800

S27A5
Long-chain fatty acid transport protein 5

1

1

High-throughput

0.407

High

719699

HLAF
HLA class I histocompatibility antigen, alpha chain F

3

0

High-throughput

0.347

High

833722

NDP
Norrin

1

0

High-throughput

0.279

Low

833738

CART

1

0

High-throughput

0.279

Low

833739

INSC
Protein inscuteable homolog

1

0

High-throughput

0.279

Low

833742

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

833779

GHC1
Mitochondrial glutamate carrier 1

1

0

High-throughput

0.279

Low

65408

MFS2B
Sphingosine-1-phosphate transporter MFSD2B

1

0

High-throughput

0.232

Low

833711

SL9A3
Sodium/hydrogen exchanger 3

1

0

High-throughput

0.232

Low

833727

YL016
Putative uncharacterized protein LOC100128554

1

0

High-throughput

0.232

Low

833737

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

833750

S47A2
Multidrug and toxin extrusion protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025