HitPredict

Interactor 1: CLK1 (P49759)
Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
Gene: CLK1

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.555

Property	Details
Experiments	34133714
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 484 Hs			1 282
+	Hs
		833957 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		834109 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		625400 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		833874 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516362 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		516416 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		834030 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		834033 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		516417 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Dm
		834186 DOA_DROME (14-481): 1.35e-115: 361: 44.86		Q9V3T8_DROME (5-181): 7.07e-31: 115: 50.83
+	Hs
		1020254 DYR1A_HUMAN (40-478): 3.05e-103: 326: 25.15		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		1031320 DYR1A_HUMAN (40-478): 3.05e-103: 326: 25.15		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		516508 DYR1A_HUMAN (40-478): 3.05e-103: 326: 25.15		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		1043781 DYR1A_HUMAN (40-478): 3.05e-103: 326: 25.15		CIRBP_HUMAN (16-160): 2.29e-19: 85: 33.79