HitPredict

Interactor 1: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Interactor 2: RNPS1 (Q15287)
RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)
Gene: RNPS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	25416956, 28514442, 32296183, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 499 Hs			1 305
+	Hs
		88031 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		D3DU92_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		834048 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		625442 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		SART3_HUMAN (2-302): 1.67e-38: 146: 16.32
+	Hs
		516416 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		516417 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		834033 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP4_HUMAN (153-248): 4.98e-19: 89.2: 27.08
+	Hs
		516362 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		853953 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06
+	Hs
		414928 CDK1_HUMAN (160-485): 3.05e-114: 340: 23.95		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		1043810 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		853885 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06
+	Hs
		516508 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		1031320 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		PABP4_HUMAN (153-248): 4.98e-19: 89.2: 27.08
+	At
		621700 CDKA1_ARATH (160-486): 4.5e-118: 350: 23.65		RB45A_ARATH (102-252): 2.53e-10: 62.6: 13.07
+	Sc
		688523 KNS1_YEAST (146-418): 3.57e-66: 228: 39.45		HRB1_YEAST (134-240): 1.35e-09: 60.7: 13.08