HitPredict

Interactor 1: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	28514442, 32296183, 33961781, 34133714, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, two hybrid prey pooling approach, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 638 Hs			1 282
+	Hs
		834030 CLK3_HUMAN (1-638): 0: 542: 100.00		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		834033 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		516417 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		833805 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		833957 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		625400 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		833874 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516362 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		516416 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Dm
		834186 DOA_DROME (36-635): 2.7e-120: 378: 37.52		Q9V3T8_DROME (5-181): 7.07e-31: 115: 50.83
+	Hs
		1020254 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		1031320 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		516508 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		1043781 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		CIRBP_HUMAN (16-160): 2.29e-19: 85: 33.79