Protein: C1TC
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]

Gene: C1TC, ADE3
Organism: Saccharomyces cerevisiae S288C
Interactions: 67
UniProt ID: P07245

Gene Ontology (top 5):
GO:0000105 - L-histidine biosynthetic process
GO:0004329 - formate-tetrahydrofolate ligase activity
GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity
GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

423495

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

5

Small-scale

0.691

High

423497

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

5

High-throughput

0.665

High

423502

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.601

High

423529

TM108
Protein TMA108

2

1

High-throughput

0.601

High

423498

RL2A
Large ribosomal subunit protein uL2A

2

1

High-throughput

0.584

High

423504

CAF20
Cap-associated protein CAF20

2

1

High-throughput

0.584

High

423507

HSC82
ATP-dependent molecular chaperone HSC82

2

7

High-throughput

0.584

High

423514

RL16A
Large ribosomal subunit protein uL13A

2

2

High-throughput

0.584

High

423515

TF2B
Transcription initiation factor IIB

2

2

High-throughput

0.576

High

423500

HSP71
Heat shock protein SSA1

2

7

High-throughput

0.552

High

423518

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.536

High

423519

PTK1
Serine/threonine-protein kinase PTK1/STK1

1

3

High-throughput

0.536

High

423533

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.536

High

423544

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.536

High

423496

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

423510

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.513

High

423511

FKBP
FK506-binding protein 1

1

0

High-throughput

0.513

High

423512

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.493

High

357425

RLA4
Large ribosomal subunit protein P2B

1

3

High-throughput

0.479

High

365570

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

399265

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.479

High

410249

SC160
Protein SCP160

1

1

High-throughput

0.479

High

423499

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.479

High

423505

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

423508

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

423513

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

423516

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

423525

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

423526

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

423527

ARB1
ABC transporter ATP-binding protein ARB1

1

1

Small-scale

0.479

High

423531

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

423534

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

423535

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.479

High

423538

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

423539

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

423541

RL21A
Large ribosomal subunit protein eL21A

1

2

High-throughput

0.479

High

423543

TOM1
E3 ubiquitin-protein ligase TOM1

1

5

High-throughput

0.479

High

423546

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

423548

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

423550

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

423553

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

389192

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

423503

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

423506

CPYI
Carboxypeptidase Y inhibitor

1

0

Small-scale

0.458

High

423522

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.458

High

423524

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

423530

INP51
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51

1

0

High-throughput

0.458

High

423542

COFI
Cofilin

1

0

High-throughput

0.458

High

423547

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

423551

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

423552

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

367613

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

423501

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

423523

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

423528

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

423537

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.445

High

399819

RLA2
Large ribosomal subunit protein P2A

1

3

High-throughput

0.437

High

423520

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

423532

MID1
Stretch-activated cation channel MID1

1

1

Small-scale

0.437

High

423540

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.437

High

423509

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

423521

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.426

High

423517

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

423536

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

423545

PEX29
Peroxisomal membrane protein PEX29

1

0

Small-scale

0.249

Low

423549

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024