Interactor 1: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1
Interactor 2: PEN2 (Q9NZ42)
Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)
Gene: PSENEN
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.971 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 22074918, 14572442, 21115843, 12198112, 12639958, 32296183, 15474363, 15322109, unassigned1304, 25394380 |
| Identification Methods | affinity chromatography technology, enzymatic study, two hybrid, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, anti bait coimmunoprecipitation, validated two hybrid |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PEN-2~Presenilin |
| Common GO terms | GO:0000139 - Golgi membrane GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane and 11 others more... |
| Homologous interactions | 7 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
