Protein: GARS
Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1)

Gene: GARS, GARS1
Organism: Homo sapiens
Interactions: 169
UniProt ID: P41250

Gene Ontology (top 5):
GO:0004081 - bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO:0004820 - glycine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

834268

GARS
Glycine--tRNA ligase

2

1

Small-scale

0.812

High

834284

TERA
Transitional endoplasmic reticulum ATPase

4

1

High-throughput

0.672

High

610253

PRS6A
26S proteasome regulatory subunit 6A

3

3

High-throughput

0.667

High

240977

PRKN
E3 ubiquitin-protein ligase parkin

3

1

High-throughput

0.640

High

371380

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

415402

HSPB1
Heat shock protein beta-1

2

1

Small-scale

0.614

High

834374

HDAC6
Protein deacetylase HDAC6

2

1

Small-scale

0.601

High

834287

UBC12
NEDD8-conjugating enzyme Ubc12

2

0

Small-scale

0.598

High

834343

LS14A
Protein LSM14 homolog A

2

1

High-throughput

0.584

High

714782

EF1D
Elongation factor 1-delta

1

1

Small-scale

0.573

High

834304

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

1

Small-scale

0.561

High

345473

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

536664

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.559

High

834372

CHD7
Chromodomain-helicase-DNA-binding protein 7

2

0

High-throughput

0.559

High

834272

MK08
Mitogen-activated protein kinase 8

1

1

High-throughput

0.541

High

834298

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

1

High-throughput

0.541

High

834316

NEDD8
Ubiquitin-like protein NEDD8

1

0

Small-scale

0.537

High

213850

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

464859

SP1
Transcription factor Sp1

1

1

High-throughput

0.536

High

834315

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

834378

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

2

High-throughput

0.536

High

774190

BASI
Basigin

1

1

High-throughput

0.515

High

834318

BATF
Basic leucine zipper transcriptional factor ATF-like

1

1

High-throughput

0.515

High

834358

KLF6
Krueppel-like factor 6

1

1

High-throughput

0.515

High

164801

UN13B
Protein unc-13 homolog B

1

0

High-throughput

0.513

High

540241

SPTB1
Spectrin beta chain, erythrocytic

1

0

High-throughput

0.513

High

563363

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

834275

NEST
Nestin

1

0

High-throughput

0.513

High

834281

PEX5
Peroxisomal targeting signal 1 receptor

1

0

High-throughput

0.513

High

834294

MAP1A
Microtubule-associated protein 1A

1

0

High-throughput

0.513

High

834314

MYLK
Myosin light chain kinase, smooth muscle

1

0

High-throughput

0.513

High

834347

CUL5
Cullin-5

1

0

High-throughput

0.513

High

834348

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

High-throughput

0.513

High

834355

SCYL1
N-terminal kinase-like protein

1

0

High-throughput

0.513

High

834385

SNX9
Sorting nexin-9

1

0

High-throughput

0.513

High

834317

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.508

High

834375

DUX4
Double homeobox protein 4

1

0

High-throughput

0.494

High

834360

SPAG8
Sperm-associated antigen 8

1

0

High-throughput

0.493

High

834379

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.493

High

834269

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

2

Small-scale

0.481

High

279684

CISY
Citrate synthase, mitochondrial

1

1

High-throughput

0.479

High

315230

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

405868

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

606368

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

828694

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

834273

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

834277

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

834280

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

834283

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

834285

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

834291

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

834301

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

834305

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

834306

DX39B
Spliceosome RNA helicase DDX39B

1

2

Small-scale

0.479

High

834307

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

834319

CRY1
Cryptochrome-1

1

1

High-throughput

0.479

High

834322

TECT1
Tectonic-1

1

1

High-throughput

0.479

High

834324

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

834373

SYLC
Leucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

61447

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

141358

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

159549

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

184272

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

289946

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

293327

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

319486

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

324619

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

349849

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

379922

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

400427

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

411513

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

413342

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

470899

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

667610

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

681285

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

766270

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

798797

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

800420

LICH
Lysosomal acid lipase/cholesteryl ester hydrolase

1

0

High-throughput

0.458

High

830275

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

834270

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

834271

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

834274

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

834278

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

834282

TTC3
E3 ubiquitin-protein ligase TTC3

1

0

High-throughput

0.458

High

834288

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

834290

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

834293

ELF3
ETS-related transcription factor Elf-3

1

0

High-throughput

0.458

High

834295

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.458

High

834296

VIGLN
Vigilin

1

0

High-throughput

0.458

High

834297

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

834299

MPPA
Mitochondrial-processing peptidase subunit alpha

1

0

High-throughput

0.458

High

834300

MERTK
Tyrosine-protein kinase Mer

1

0

High-throughput

0.458

High

834302

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

834303

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

834309

CUL7
Cullin-7

1

0

High-throughput

0.458

High

834310

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

834311

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

834312

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.458

High

834313

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

834320

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

834321

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.458

High

834326

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

834328

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

834329

FTM
Protein fantom

1

0

High-throughput

0.458

High

834330

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

834331

ANO7
Anoctamin-7

1

0

Small-scale

0.458

High

834333

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

834336

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

834337

S2542
Mitochondrial coenzyme A transporter SLC25A42

1

0

High-throughput

0.458

High

834338

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.458

High

834339

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

834340

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

834341

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

834342

POC5
Centrosomal protein POC5

1

0

High-throughput

0.458

High

834344

FBF1
Fas-binding factor 1

1

0

High-throughput

0.458

High

834346

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

834349

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

834350

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

834351

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

834352

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

834354

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

834356

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

834357

DRC1
Dynein regulatory complex protein 1

1

0

High-throughput

0.458

High

834359

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.458

High

834362

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

834363

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

834364

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

834365

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

834367

ANLN
Anillin

1

0

High-throughput

0.458

High

834368

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

834369

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

834370

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

834371

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

834376

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

834377

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

834381

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

0

High-throughput

0.458

High

834383

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

834384

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.458

High

834286

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

1

High-throughput

0.445

High

834327

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

834366

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

0

High-throughput

0.438

High

834332

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

374443

RASH
GTPase HRas

1

0

High-throughput

0.426

High

404712

PRIO
Major prion protein

1

0

High-throughput

0.426

High

529268

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

834292

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.426

High

834353

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

834386

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

429458

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

834279

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

105495

APRIO
Alternative prion protein

2

0

High-throughput

0.305

High

834323

DB136
Defensin beta 136

1

0

High-throughput

0.279

Low

834345

SOCS4
Suppressor of cytokine signaling 4

1

0

High-throughput

0.268

Low

834361

Q9BR81
Protocadherin gamma subfamily C, 3

1

0

High-throughput

0.268

Low

337210

LCA5L
Lebercilin-like protein

1

0

High-throughput

0.249

Low

353065

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

473840

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.249

Low

588102

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

694818

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

767594

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

834276

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

834289

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

834308

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

834325

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

834334

ASXL2
Putative Polycomb group protein ASXL2

1

0

High-throughput

0.249

Low

834335

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

834380

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low

834382

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025