HitPredict

Interactor 1: NU153 (P49790)
Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)
Gene: NUP153

Interactor 2: IMA5 (P52294)
Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]
Gene: KPNA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	26496610, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005643 - nuclear pore GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus GO:0008139 - nuclear localization sequence binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1475 Hs			1 538
+	Hs
		238649 NU153_HUMAN (1-1475): 2.98e-176: 568: 100.00		IMA7_HUMAN (1-538): 6.51e-160: 467: 80.48
+	Hs
		134853 NU153_HUMAN (1-1475): 2.98e-176: 568: 100.00		IMA3_HUMAN (1-538): 7e-156: 456: 45.84
+	Hs
		168626 NU153_HUMAN (1-1475): 2.98e-176: 568: 100.00		IMA6_HUMAN (1-538): 1.39e-152: 449: 79.59
+	Hs
		131403 NU153_HUMAN (1-1475): 2.98e-176: 568: 100.00		IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91
+	Hs
		834565 NU153_HUMAN (1-1475): 2.98e-176: 568: 100.00		IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36
+	Hs
		834694 RBP2_HUMAN (573-1152): 6.9e-53: 207: 19.12		IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00
+	Hs
		134854 RBP2_HUMAN (573-1152): 6.9e-53: 207: 19.12		IMA3_HUMAN (1-538): 7e-156: 456: 45.84
+	Hs
		131404 RBP2_HUMAN (573-1152): 6.9e-53: 207: 19.12		IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91
+	Hs
		834693 RBP2_HUMAN (573-1152): 6.9e-53: 207: 19.12		IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36
+	Hs
		134921 RGPD4_HUMAN (1136-1440): 1.07e-38: 160: 16.39		IMA3_HUMAN (1-538): 7e-156: 456: 45.84
+	Dm
		1359634 Q9VGL0_DROME (152-1380): 3.82e-45: 181: 10.93		Q9V455_DROME (4-538): 9.55e-147: 433: 44.49
+	Hs
		63862 RGPD3_HUMAN (1136-1440): 4.22e-38: 158: 16.39		IMA3_HUMAN (1-538): 7e-156: 456: 45.84
+	Hs
		853440 RGPD5_HUMAN (1136-1440): 7.32e-39: 161: 16.72		IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36
+	Hs
		152769 RGPD8_HUMAN (1136-1440): 1.82e-37: 156: 16.72		IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36
+	Sp
		293244 NU124_SCHPO (702-1470): 4.84e-40: 164: 11.67		IMA2_SCHPO (8-538): 1.37e-143: 426: 49.16
+	Hs
		131388 NU214_HUMAN (146-1306): 4.07e-29: 129: 11.13		IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91
+	Hs
		134976 ZRAN1_HUMAN (589-796): 5.46e-22: 105: 16.89		IMA3_HUMAN (1-538): 7e-156: 456: 45.84
+	Hs
		131525 ZRAN1_HUMAN (589-796): 5.46e-22: 105: 16.89		IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91
+	Sc
		691660 NUP2_YEAST (923-1394): 5.12e-24: 111: 17.83		IMA1_YEAST (2-538): 8.07e-143: 424: 49.26
+	Sc
		595062 NUP1_YEAST (863-1451): 7.24e-23: 108: 18.05		IMA1_YEAST (2-538): 8.07e-143: 424: 49.26