HitPredict

Interactor 1: RGS19 (P49795)
Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP)
Gene: RGS19

Interactor 2: GNAI1 (P63096)
Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	10364213, 8986788
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 354
+	Hs
		444691 RGS19_HUMAN (1-217): 1.96e-82: 246: 100.00		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		391356 RGS19_HUMAN (1-217): 1.96e-82: 246: 100.00		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		450988 RGS19_HUMAN (1-217): 1.96e-82: 246: 100.00		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Hs
		283183 RGS20_HUMAN (14-213): 1.27e-67: 214: 56.50		GNAI1_HUMAN (1-354): 0: 512: 100.00
+	Hs
		207517 RGS14_HUMAN (66-207): 2.04e-61: 202: 37.24		GNAI1_HUMAN (1-354): 0: 512: 100.00
+	Hs
		283156 RGS20_HUMAN (14-213): 1.27e-67: 214: 56.50		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		158608 RGS12_HUMAN (71-207): 2.87e-57: 197: 36.69		GNAI1_HUMAN (1-354): 0: 512: 100.00
+	Hs
		926723 RGS17_HUMAN (57-217): 5.89e-63: 196: 59.63		GNAI1_HUMAN (1-354): 0: 512: 100.00
+	Hs
		207507 RGS14_HUMAN (66-207): 2.04e-61: 202: 37.24		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		283160 RGS20_HUMAN (14-213): 1.27e-67: 214: 56.50		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Hs
		207505 RGS14_HUMAN (66-207): 2.04e-61: 202: 37.24		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		158599 RGS12_HUMAN (71-207): 2.87e-57: 197: 36.69		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		580409 RGS19_HUMAN (1-217): 1.96e-82: 246: 100.00		GNAZ_HUMAN (1-353): 2.73e-160: 454: 67.23
+	Hs
		444806 RGS17_HUMAN (57-217): 5.89e-63: 196: 59.63		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		158597 RGS12_HUMAN (71-207): 2.87e-57: 197: 36.69		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Mm
		579646 RGS14_MOUSE (66-207): 1.32e-60: 200: 34.48		GNAO_MOUSE (1-354): 1.59e-172: 485: 71.83
+	Bt
		221230 RGS9_BOVIN (24-217): 9.29e-60: 196: 29.08		GNAT1_BOVIN (1-354): 8.16e-169: 475: 67.80
+	Hs
		283162 RGS20_HUMAN (14-213): 1.27e-67: 214: 56.50		GNAZ_HUMAN (1-353): 2.73e-160: 454: 67.23
+	Hs
		207511 RGS14_HUMAN (66-207): 2.04e-61: 202: 37.24		GNA11_HUMAN (1-353): 1.33e-162: 460: 51.13
+	Hs
		170629 AXIN1_HUMAN (15-213): 1.08e-59: 202: 23.79		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23