Protein: IF2B
Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta)

Gene: IF2B, EIF2S2
Organism: Homo sapiens
Interactions: 209
UniProt ID: P20042

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0001731 - formation of translation preinitiation complex
GO:0002176 - male germ cell proliferation
GO:0002183 - cytoplasmic translational initiation
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

627606

IF2G
Eukaryotic translation initiation factor 2 subunit 3

14

7

Small-scale

0.981

High

426200

IF2A
Eukaryotic translation initiation factor 2 subunit 1

6

6

Small-scale

0.733

High

293186

CD123
Translation initiation factor eIF2 assembly protein

6

2

Small-scale

0.729

High

627719

ANM7
Protein arginine N-methyltransferase 7

4

2

Small-scale

0.694

High

581430

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

High-throughput

0.691

High

627634

CSK21
Casein kinase II subunit alpha

3

4

Small-scale

0.689

High

421476

A4
Amyloid-beta precursor protein

3

2

High-throughput

0.660

High

395477

ESR1
Estrogen receptor

3

1

Small-scale

0.641

High

627625

IF5
Eukaryotic translation initiation factor 5

2

3

Small-scale

0.619

High

627659

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.618

High

529055

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.601

High

413171

P53
Cellular tumor antigen p53

2

0

Small-scale

0.588

High

429287

JUN
Transcription factor Jun

2

3

High-throughput

0.588

High

240728

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

627596

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

1

High-throughput

0.584

High

593901

NCK1
SH2/SH3 adapter protein NCK1

1

1

Small-scale

0.573

High

627633

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.564

High

627704

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

436606

KPCB
Protein kinase C beta type

2

0

High-throughput

0.547

High

627689

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

2

0

High-throughput

0.547

High

627640

TLE1
Transducin-like enhancer protein 1

1

2

High-throughput

0.541

High

295088

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

4

High-throughput

0.536

High

303413

SRP72
Signal recognition particle subunit SRP72

1

2

High-throughput

0.536

High

563172

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

627611

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.536

High

627612

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

627626

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

5

High-throughput

0.536

High

627628

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

627630

RS11
Small ribosomal subunit protein uS17

1

2

High-throughput

0.536

High

627632

RACK1
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.536

High

627638

TIE2
Angiopoietin-1 receptor

1

4

High-throughput

0.536

High

627653

RBM39
RNA-binding protein 39

1

2

High-throughput

0.536

High

627685

PSPC1
Paraspeckle component 1

1

3

High-throughput

0.536

High

627702

RBM42
RNA-binding protein 42

1

1

High-throughput

0.536

High

627727

CSN7A
COP9 signalosome complex subunit 7a

1

1

High-throughput

0.536

High

627730

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.536

High

627735

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

High-throughput

0.536

High

627737

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

627635

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

5

Small-scale

0.534

High

259429

BRD4
Bromodomain-containing protein 4

2

2

High-throughput

0.533

High

371141

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.533

High

587892

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.533

High

627601

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.533

High

601556

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.527

High

627641

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.518

High

627646

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.518

High

627650

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.518

High

627724

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.518

High

627742

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

High-throughput

0.518

High

627673

KTN1
Kinectin

1

1

High-throughput

0.515

High

627592

RAB6A
Ras-related protein Rab-6A

1

1

High-throughput

0.515

High

627608

HD
Huntingtin

1

2

High-throughput

0.515

High

479321

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

542328

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

627609

DCC
Netrin receptor DCC

1

0

Small-scale

0.513

High

627614

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

627615

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

627618

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

627652

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

627662

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

627675

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

627679

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

627688

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.513

High

627698

DNJC2
DnaJ homolog subfamily C member 2

1

0

High-throughput

0.513

High

627712

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.513

High

627713

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.513

High

627740

EXOS1
Exosome complex component CSL4

1

0

High-throughput

0.513

High

627741

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.513

High

185421

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

627744

5MP1
eIF5-mimic protein 1

1

7

Small-scale

0.501

High

627621

APLP1
Amyloid beta precursor like protein 1

1

2

High-throughput

0.494

High

627657

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.493

High

627732

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

376945

NGF
Beta-nerve growth factor

1

0

High-throughput

0.493

High

627610

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

High-throughput

0.493

High

627623

ATX1
Ataxin-1

1

0

High-throughput

0.493

High

627687

SORL
Sortilin-related receptor

1

0

High-throughput

0.493

High

627690

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

627699

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

0

High-throughput

0.493

High

160806

TOR1B
Torsin-1B

1

4

High-throughput

0.489

High

627598

LTK
Leukocyte tyrosine kinase receptor

1

7

High-throughput

0.489

High

156947

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

172466

XPO1
Exportin-1

1

5

High-throughput

0.479

High

245197

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

4

High-throughput

0.479

High

315105

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

345359

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

472453

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.479

High

486947

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

536478

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

541330

FGFR1
Fibroblast growth factor receptor 1

1

8

High-throughput

0.479

High

606205

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

609949

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.479

High

627594

DDX6
Probable ATP-dependent RNA helicase DDX6

1

2

High-throughput

0.479

High

627595

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

2

High-throughput

0.479

High

627602

VGFR3
Vascular endothelial growth factor receptor 3

1

5

High-throughput

0.479

High

627607

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.479

High

627617

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.479

High

627619

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

627629

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

627637

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

8

High-throughput

0.479

High

627639

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

627642

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

627643

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

8

High-throughput

0.479

High

627644

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

627645

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

627647

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

627654

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

627656

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

3

High-throughput

0.479

High

627658

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

627666

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

627667

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

627671

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

627678

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

627681

ZCHC7
Zinc finger CCHC domain-containing protein 7

1

2

High-throughput

0.479

High

627686

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

627691

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

627700

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

627703

RNF26
E3 ubiquitin-protein ligase RNF26

1

2

High-throughput

0.479

High

627705

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

High-throughput

0.479

High

627709

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

627716

ANLN
Anillin

1

1

High-throughput

0.479

High

627725

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

627726

KS6B2
Ribosomal protein S6 kinase beta-2

1

2

High-throughput

0.479

High

627729

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

627734

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

627736

CC14A
Dual specificity protein phosphatase CDC14A

1

1

High-throughput

0.479

High

627738

FBW1A
F-box/WD repeat-containing protein 1A

1

3

High-throughput

0.479

High

627743

RBM8A
RNA-binding protein 8A

1

3

High-throughput

0.479

High

247668

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

302369

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

High-throughput

0.458

High

319386

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

478657

HXB5
Homeobox protein Hox-B5

1

0

High-throughput

0.458

High

627597

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

High-throughput

0.458

High

627600

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

627605

SPB5
Serpin B5

1

0

High-throughput

0.458

High

627613

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

627620

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

627622

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.458

High

627624

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

627631

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

627649

CUL3
Cullin-3

1

0

High-throughput

0.458

High

627651

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.458

High

627655

CUL7
Cullin-7

1

0

High-throughput

0.458

High

627660

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

627664

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

627665

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

627669

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

627670

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.458

High

627672

LYRIC
Protein LYRIC

1

0

Small-scale

0.458

High

627674

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

627680

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

627683

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

627692

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

627694

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

627696

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

627697

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.458

High

627701

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

627707

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

627714

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

627715

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

627718

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

627731

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

627739

KLH20
Kelch-like protein 20

1

0

High-throughput

0.458

High

400262

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.445

High

627636

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

Small-scale

0.445

High

105311

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

318618

RHBT1
Rho-related BTB domain-containing protein 1

1

2

High-throughput

0.437

High

377401

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

405781

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

411336

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

465402

IGF1R
Insulin-like growth factor 1 receptor

1

7

High-throughput

0.437

High

477206

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

6

High-throughput

0.437

High

627593

FGFR3
Fibroblast growth factor receptor 3

1

8

High-throughput

0.437

High

627599

UFO
Tyrosine-protein kinase receptor UFO

1

4

High-throughput

0.437

High

627603

VGFR2
Vascular endothelial growth factor receptor 2

1

5

High-throughput

0.437

High

627604

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.437

High

627627

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

627677

LMTK2
Serine/threonine-protein kinase LMTK2

1

7

High-throughput

0.437

High

627695

LMTK3
Serine/threonine-protein kinase LMTK3

1

8

High-throughput

0.437

High

354535

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

627648

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

627676

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.407

High

627706

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

627616

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

627708

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.282

High

591473

H2AX
Histone H2AX

1

0

High-throughput

0.279

Low

47304

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

622120

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

179818

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

279279

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

352950

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

415990

CP1A1
Cytochrome P450 1A1

1

0

High-throughput

0.249

Low

568359

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

627661

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low

627668

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.249

Low

627711

SFXN1
Sideroflexin-1

1

0

High-throughput

0.249

Low

627717

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low

627720

ANO10
Anoctamin-10

1

0

High-throughput

0.249

Low

627721

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.249

Low

627722

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

627723

MBD5
Methyl-CpG-binding domain protein 5

1

0

High-throughput

0.249

Low

627733

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

62446

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

627663

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

627682

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

627684

MSPD2
Motile sperm domain-containing protein 2

1

0

High-throughput

0.232

Low

627693

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.232

Low

627710

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low

627728

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025