HitPredict

Interactor 1: GNAI2 (P50147)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: BRAF (Q04982)
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (Proto-oncogene c-Rmil) (Serine/threonine-protein kinase Rmil)
Gene: BRAF

Species: Gallus gallus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27034005
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0046872 - metal ion binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 355 Gg			1 766
+	Hs
		391319 GNAI2_HUMAN (1-355): 8.06e-179: 501: 95.21		BRAF_HUMAN (1-766): 0: 754: 93.89
+	Mm
		444633 GNAI2_MOUSE (1-355): 2.98e-177: 497: 94.37		BRAF_MOUSE (9-766): 0: 713: 89.74
+	Mm
		655984 GNAI3_MOUSE (1-355): 4.89e-173: 486: 86.48		BRAF_MOUSE (9-766): 0: 713: 89.74
+	Hs
		542856 GNAS2_HUMAN (1-355): 1.5e-143: 413: 37.82		BRAF_HUMAN (1-766): 0: 754: 93.89
+	Hs
		373499 GNAI2_HUMAN (1-355): 8.06e-179: 501: 95.21		RAF1_HUMAN (100-755): 0: 577: 54.33
+	Hs
		374020 GNAI1_HUMAN (1-355): 8.45e-178: 498: 89.58		RAF1_HUMAN (100-755): 0: 577: 54.33
+	Hs
		374019 GNAS2_HUMAN (1-355): 1.5e-143: 413: 37.82		RAF1_HUMAN (100-755): 0: 577: 54.33
+	Hs
		444699 GNAI3_HUMAN (1-355): 1.52e-174: 490: 86.48		EPHA4_HUMAN (107-747): 1.41e-147: 458: 19.03
+	Hs
		580464 GNAT2_HUMAN (1-355): 1.03e-166: 470: 69.86		EPHA4_HUMAN (107-747): 1.41e-147: 458: 19.03
+	Hs
		580414 GNAZ_HUMAN (1-354): 1.59e-158: 450: 67.23		EPHA4_HUMAN (107-747): 1.41e-147: 458: 19.03
+	Hs
		488664 GNAS2_HUMAN (1-355): 1.5e-143: 413: 37.82		ARAF_HUMAN (143-750): 1.58e-165: 492: 55.88
+	Hs
		872647 GNA13_HUMAN (2-354): 1.57e-154: 440: 38.89		EPHA4_HUMAN (107-747): 1.41e-147: 458: 19.03