HitPredict

Interactor 1: LHX2 (P50458)
LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2)
Gene: LHX2

Interactor 2: LDB1 (Q86U70)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)
Gene: LDB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.904

Property	Details
Experiments	32296183, 35140242, 20211142, unassigned1304
Identification Methods	two hybrid, proximity labelling technology, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0000785 - chromatin GO:0001942 - hair follicle development GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0030182 - neuron differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 411
+	Mm
		936893 LHX2_MOUSE (1-406): 2.05e-98: 300: 99.02		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Hs
		1199143 LHX9_HUMAN (1-406): 3.73e-76: 243: 61.58		LDB1_HUMAN (1-411): 0: 760: 100.00
+	Mm
		936891 LHX9_MOUSE (1-406): 3.76e-74: 238: 61.33		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Mm
		936889 LMX1A_MOUSE (27-402): 3.01e-51: 178: 25.33		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Mm
		899945 LHX5_MOUSE (53-402): 9.6e-51: 177: 27.92		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Hs
		903745 LMO4_HUMAN (33-186): 6.88e-53: 175: 37.58		LDB1_HUMAN (1-411): 0: 760: 100.00
+	Mm
		903798 LMO4_MOUSE (33-186): 6.88e-53: 175: 37.58		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Mm
		925846 LHX1_MOUSE (53-404): 7.71e-50: 175: 26.63		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Hs
		822644 LHX1_HUMAN (53-404): 1.01e-49: 174: 26.63		LDB1_HUMAN (1-411): 0: 760: 100.00
+	Mm
		223263 LHX2_MOUSE (1-406): 2.05e-98: 300: 99.02		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Mm
		223262 LHX9_MOUSE (1-406): 3.76e-74: 238: 61.33		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Dm
		185764 Q9VTW5_DROME (52-388): 9.82e-72: 238: 27.52		O18353_DROME (8-391): 0: 594: 56.89
+	Dm
		114400 M9PCA3_DROME (52-388): 9.23e-72: 238: 27.52		Q7KVG9_DROME (8-391): 0: 593: 56.89
+	Mm
		223259 LMX1A_MOUSE (27-402): 3.01e-51: 178: 25.33		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Mm
		223247 LHX5_MOUSE (53-402): 9.6e-51: 177: 27.92		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Mm
		223248 LMO4_MOUSE (33-186): 6.88e-53: 175: 37.58		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Mm
		223249 LHX1_MOUSE (53-404): 7.71e-50: 175: 26.63		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Dm
		185745 APTE_DROME (8-367): 3.48e-59: 201: 38.25		O18353_DROME (8-391): 0: 594: 56.89
+	Hs
		210831 LMO4_HUMAN (33-186): 6.88e-53: 175: 37.58		LDB2_HUMAN (44-411): 0: 620: 76.69
+	Dm
		669259 APTE_DROME (8-367): 3.48e-59: 201: 38.25		Q7KVG9_DROME (8-391): 0: 593: 56.89