HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	33545068, 32814053
Identification Methods	proximity labelling technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0006914 - autophagy and 1 others more... GO:0007165 - signal transduction
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 577
+	Hs
		840702 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		840691 DYN2_HUMAN (1-870): 0: 1057: 100.00		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Mm
		760488 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (1-363): 2.07e-11: 69.3: 12.09
+	Hs
		983379 DYN1_HUMAN (1-846): 0: 1002: 79.04		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Rn
		599413 DYN1_RAT (1-846): 0: 994: 78.57		ITSN1_RAT (38-416): 1.68e-18: 92: 13.13
+	Mm
		760469 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (1-363): 2.07e-11: 69.3: 12.09
+	Hs
		128615 DNM1L_HUMAN (6-743): 0: 787: 39.13		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		128473 DNM1L_HUMAN (6-743): 0: 787: 39.13		MYH11_HUMAN (263-576): 6.07e-11: 67.9: 15.36