Protein: MCM4
DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)

Gene: MCM4
Organism: Homo sapiens
Interactions: 228
UniProt ID: P33991

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

708387

MCM7
DNA replication licensing factor MCM7

13

18

Small-scale

0.979

High

708400

MCM2
DNA replication licensing factor MCM2

10

19

Small-scale

0.973

High

708441

MCM6
DNA replication licensing factor MCM6

10

19

Small-scale

0.971

High

627193

MCM3
DNA replication licensing factor MCM3

4

20

Small-scale

0.895

High

708556

ORC6
Origin recognition complex subunit 6

2

4

Small-scale

0.793

High

708386

MCM5
DNA replication licensing factor MCM5

2

18

Small-scale

0.789

High

264176

CDC45
Cell division control protein 45 homolog

2

14

Small-scale

0.754

High

708427

SSRP1
FACT complex subunit SSRP1

5

11

Small-scale

0.727

High

708515

CDT1
DNA replication factor Cdt1

1

6

Small-scale

0.724

High

708504

MCMBP
Mini-chromosome maintenance complex-binding protein

4

17

Small-scale

0.717

High

708413

H4
Histone H4

4

7

Small-scale

0.694

High

346065

MYC
Myc proto-oncogene protein

4

5

High-throughput

0.672

High

708474

MCM10
Protein MCM10 homolog

3

12

High-throughput

0.667

High

708493

H2B1A
Histone H2B type 1-A

3

20

High-throughput

0.667

High

708527

ASF1B
Histone chaperone ASF1B

3

10

High-throughput

0.667

High

708548

ASF1A
Histone chaperone ASF1A

3

10

Small-scale

0.667

High

708428

EP300
Histone acetyltransferase p300

3

11

Small-scale

0.660

High

708406

PLK1
Serine/threonine-protein kinase PLK1

3

8

Small-scale

0.656

High

708415

H31
Histone H3.1

3

20

High-throughput

0.656

High

125850

CDC7
Cell division cycle 7-related protein kinase

3

17

Small-scale

0.650

High

708537

DBF4A
Protein DBF4 homolog A

3

5

Small-scale

0.650

High

552057

RFA2
Replication protein A 32 kDa subunit

3

5

Small-scale

0.642

High

555318

H2AX
Histone H2AX

2

20

High-throughput

0.628

High

708551

LMBL1
Lethal(3)malignant brain tumor-like protein 1

2

4

Small-scale

0.628

High

708492

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

6

Small-scale

0.621

High

217234

ORC5
Origin recognition complex subunit 5

1

20

Small-scale

0.621

High

217779

ORC4
Origin recognition complex subunit 4

1

18

Small-scale

0.621

High

708385

MCM4
DNA replication licensing factor MCM4

1

18

Small-scale

0.621

High

708417

CCNA1
Cyclin-A1

2

3

Small-scale

0.619

High

708503

SLD5
DNA replication complex GINS protein SLD5

1

13

Small-scale

0.618

High

708540

MCM8
DNA helicase MCM8

1

19

Small-scale

0.618

High

391569

H2A1B
Histone H2A type 1-B/E

2

20

High-throughput

0.611

High

455137

PARP1
Poly [ADP-ribose] polymerase 1

2

8

High-throughput

0.611

High

708436

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

12

High-throughput

0.611

High

708438

CUL3
Cullin-3

2

6

High-throughput

0.611

High

708489

ING5
Inhibitor of growth protein 5

2

3

Small-scale

0.611

High

708498

TONSL
Tonsoku-like protein

2

9

Small-scale

0.611

High

625167

CDK2
Cyclin-dependent kinase 2

2

9

Small-scale

0.602

High

708555

SP16H
FACT complex subunit SPT16

1

4

Small-scale

0.589

High

650487

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

6

Small-scale

0.586

High

226658

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

294442

RECQ4
ATP-dependent DNA helicase Q4

2

13

Small-scale

0.584

High

708414

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

708432

TIF1B
Transcription intermediary factor 1-beta

2

16

Small-scale

0.584

High

708510

FACD2
Fanconi anemia group D2 protein

2

8

Small-scale

0.584

High

708435

ORC2
Origin recognition complex subunit 2

2

7

Small-scale

0.576

High

708423

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

10

High-throughput

0.571

High

708460

ESCO2
N-acetyltransferase ESCO2

1

6

Small-scale

0.552

High

581481

VCAM1
Vascular cell adhesion protein 1

2

7

High-throughput

0.549

High

708500

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

336389

SODC
Superoxide dismutase [Cu-Zn]

1

3

High-throughput

0.536

High

338015

EGFR
Epidermal growth factor receptor

1

4

Small-scale

0.536

High

426583

H10
Histone H1.0

1

3

High-throughput

0.536

High

452647

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

508359

TOP1
DNA topoisomerase 1

1

6

High-throughput

0.536

High

528653

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

535807

MIF
Macrophage migration inhibitory factor

1

4

High-throughput

0.536

High

564813

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

High-throughput

0.536

High

708395

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.536

High

708398

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.536

High

708401

NU153
Nuclear pore complex protein Nup153

1

16

High-throughput

0.536

High

708405

NEK4
Serine/threonine-protein kinase Nek4

1

2

High-throughput

0.536

High

708407

FOXA3
Hepatocyte nuclear factor 3-gamma

1

5

High-throughput

0.536

High

708416

SRPK2
SRSF protein kinase 2

1

9

High-throughput

0.536

High

708419

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

3

High-throughput

0.536

High

708421

H33
Histone H3.3

1

20

High-throughput

0.536

High

708443

NUMA1
Nuclear mitotic apparatus protein 1

1

14

High-throughput

0.536

High

708454

MK06
Mitogen-activated protein kinase 6

1

11

High-throughput

0.536

High

708455

IF16
Gamma-interferon-inducible protein 16

1

4

High-throughput

0.536

High

708456

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

708464

H2A2A
Histone H2A type 2-A

1

20

High-throughput

0.536

High

708466

IFIX
Pyrin and HIN domain-containing protein 1

1

4

High-throughput

0.536

High

708479

MYLK4
Myosin light chain kinase family member 4

1

3

High-throughput

0.536

High

708488

DNJC9
DnaJ homolog subfamily C member 9

1

3

High-throughput

0.536

High

708499

SRPK1
SRSF protein kinase 1

1

7

High-throughput

0.536

High

708508

CDK19
Cyclin-dependent kinase 19

1

12

High-throughput

0.536

High

708514

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

708523

PAK6
Serine/threonine-protein kinase PAK 6

1

3

High-throughput

0.536

High

708532

H2AW
Core histone macro-H2A.2

1

20

High-throughput

0.536

High

213300

TLX2
T-cell leukemia homeobox protein 2

1

0

High-throughput

0.518

High

708404

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

708543

ASC
Apoptosis-associated speck-like protein containing a CARD

1

0

Small-scale

0.513

High

414780

CDK1
Cyclin-dependent kinase 1

1

8

Small-scale

0.501

High

708410

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

708429

ILF2
Interleukin enhancer-binding factor 2

1

7

Small-scale

0.500

High

708420

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

708501

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.489

High

708434

ORC1
Origin recognition complex subunit 1

1

18

Small-scale

0.481

High

708535

ORC3
Origin recognition complex subunit 3

1

3

Small-scale

0.481

High

59393

SBNO1
Protein strawberry notch homolog 1

1

2

High-throughput

0.479

High

135216

E2F3
Transcription factor E2F3

1

3

Small-scale

0.479

High

148446

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

154141

CHK1
Serine/threonine-protein kinase Chk1

1

4

Small-scale

0.479

High

170275

TIF1A
Transcription intermediary factor 1-alpha

1

14

Small-scale

0.479

High

209709

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

224325

RAD21
Double-strand-break repair protein rad21 homolog

1

3

High-throughput

0.479

High

241460

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.479

High

244012

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

298205

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

302959

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

308442

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

322244

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

11

High-throughput

0.479

High

351282

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

2

High-throughput

0.479

High

369080

ESR1
Estrogen receptor

1

10

High-throughput

0.479

High

384368

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

386195

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

503540

HSP7C
Heat shock cognate 71 kDa protein

1

10

High-throughput

0.479

High

506527

BCR
Breakpoint cluster region protein

1

9

High-throughput

0.479

High

517091

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.479

High

530462

ITA4
Integrin alpha-4

1

4

High-throughput

0.479

High

569282

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

617449

CRCM
Colorectal mutant cancer protein

1

11

High-throughput

0.479

High

673250

WEE1
Wee1-like protein kinase

1

7

High-throughput

0.479

High

684436

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

707531

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

708388

PHB1
Prohibitin 1

1

6

High-throughput

0.479

High

708389

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

708390

BRCA1
Breast cancer type 1 susceptibility protein

1

7

High-throughput

0.479

High

708391

CCNF
Cyclin-F

1

8

High-throughput

0.479

High

708393

ATRX
Transcriptional regulator ATRX

1

11

Small-scale

0.479

High

708396

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

708397

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

6

High-throughput

0.479

High

708403

EMD
Emerin

1

2

Small-scale

0.479

High

708409

UBC12
NEDD8-conjugating enzyme Ubc12

1

7

High-throughput

0.479

High

708412

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

708418

RED1
Double-stranded RNA-specific editase 1

1

10

High-throughput

0.479

High

708422

HSF1
Heat shock factor protein 1

1

3

High-throughput

0.479

High

708425

SOX4
Transcription factor SOX-4

1

8

High-throughput

0.479

High

708426

DDR1
Epithelial discoidin domain-containing receptor 1

1

7

Small-scale

0.479

High

708433

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

708437

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

708439

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.479

High

708440

RBM39
RNA-binding protein 39

1

8

High-throughput

0.479

High

708442

SMC1A
Structural maintenance of chromosomes protein 1A

1

13

High-throughput

0.479

High

708445

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

708446

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

708447

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

708448

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

708449

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

708450

SF3A1
Splicing factor 3A subunit 1

1

8

High-throughput

0.479

High

708452

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

High-throughput

0.479

High

708453

CRY1
Cryptochrome-1

1

5

High-throughput

0.479

High

708458

CRY2
Cryptochrome-2

1

5

High-throughput

0.479

High

708463

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

708465

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

1

High-throughput

0.479

High

708470

MMS22
Protein MMS22-like

1

3

Small-scale

0.479

High

708473

MOB3C
MOB kinase activator 3C

1

5

High-throughput

0.479

High

708475

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

708476

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

708477

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

11

Small-scale

0.479

High

708478

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

708480

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

708482

SIR6
NAD-dependent protein deacylase sirtuin-6

1

11

High-throughput

0.479

High

708483

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.479

High

708487

TF3C2
General transcription factor 3C polypeptide 2

1

2

High-throughput

0.479

High

708490

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

708491

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.479

High

708495

ARMC5
Armadillo repeat-containing protein 5

1

10

High-throughput

0.479

High

708496

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

6

High-throughput

0.479

High

708502

SPI2B
Spindlin-2B

1

3

High-throughput

0.479

High

708505

RN126
E3 ubiquitin-protein ligase RNF126

1

2

High-throughput

0.479

High

708506

DUS23
Dual specificity protein phosphatase 23

1

14

High-throughput

0.479

High

708507

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

17

Small-scale

0.479

High

708509

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

7

High-throughput

0.479

High

708512

SPRTN
DNA-dependent metalloprotease SPRTN

1

4

High-throughput

0.479

High

708513

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

708516

SENP3
Sentrin-specific protease 3

1

2

Small-scale

0.479

High

708518

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

708519

WDR76
WD repeat-containing protein 76

1

12

High-throughput

0.479

High

708520

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

1

High-throughput

0.479

High

708522

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.479

High

708524

ANLN
Anillin

1

2

High-throughput

0.479

High

708525

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

11

High-throughput

0.479

High

708528

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

2

High-throughput

0.479

High

708529

DONS
Protein downstream neighbor of Son

1

5

Small-scale

0.479

High

708530

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.479

High

708531

PD1L1
Programmed cell death 1 ligand 1

1

3

Small-scale

0.479

High

708534

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

4

High-throughput

0.479

High

708536

POLK
DNA polymerase kappa

1

1

Small-scale

0.479

High

708538

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

708539

UBQL2
Ubiquilin-2

1

8

High-throughput

0.479

High

708541

FBW1B
F-box/WD repeat-containing protein 11

1

5

High-throughput

0.479

High

708542

TF3C4
General transcription factor 3C polypeptide 4

1

2

High-throughput

0.479

High

708544

TRI33
E3 ubiquitin-protein ligase TRIM33

1

15

High-throughput

0.479

High

708545

CD11A
Cyclin-dependent kinase 11A

1

9

High-throughput

0.479

High

708546

SMC3
Structural maintenance of chromosomes protein 3

1

8

High-throughput

0.479

High

708547

HDAC5
Histone deacetylase 5

1

11

High-throughput

0.479

High

708549

FND3A
Fibronectin type-III domain-containing protein 3A

1

6

High-throughput

0.479

High

708550

GSTK1
Glutathione S-transferase kappa 1

1

1

High-throughput

0.479

High

708552

TRRAP
Transformation/transcription domain-associated protein

1

9

High-throughput

0.479

High

708554

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

9

High-throughput

0.479

High

708557

NS1BP
Influenza virus NS1A-binding protein

1

6

High-throughput

0.479

High

708402

DNLI4
DNA ligase 4

1

0

High-throughput

0.460

High

708392

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.458

High

708553

ZN451
E3 SUMO-protein ligase ZNF451

1

0

Small-scale

0.458

High

256945

KDM4A
Lysine-specific demethylase 4A

1

7

Small-scale

0.445

High

652758

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

Small-scale

0.445

High

708411

1433G
14-3-3 protein gamma

1

8

High-throughput

0.445

High

708424

UBE3A
Ubiquitin-protein ligase E3A

1

6

High-throughput

0.445

High

708431

STK4
Serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

708451

NEDD8
NEDD8

1

8

Small-scale

0.445

High

708461

ZRAB3
DNA annealing helicase and endonuclease ZRANB3

1

7

Small-scale

0.445

High

708462

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

708485

RN169
E3 ubiquitin-protein ligase RNF169

1

1

Small-scale

0.445

High

708511

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

708521

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

229633

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

14

High-throughput

0.437

High

708394

MAP1B
Microtubule-associated protein 1B

1

4

High-throughput

0.437

High

708408

FBXW4
F-box/WD repeat-containing protein 4

1

8

Small-scale

0.437

High

708430

ANK3
Ankyrin-3

1

3

High-throughput

0.437

High

708444

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

3

High-throughput

0.437

High

708457

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

708459

DUS28
Dual specificity phosphatase 28

1

7

High-throughput

0.437

High

708468

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.437

High

708471

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

708472

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

7

Small-scale

0.437

High

708481

RHG24
Rho GTPase-activating protein 24

1

9

High-throughput

0.437

High

708486

DUS19
Dual specificity protein phosphatase 19

1

7

High-throughput

0.437

High

708494

ATG2B
Autophagy-related protein 2 homolog B

1

3

High-throughput

0.437

High

708517

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

708526

DUS22
Dual specificity protein phosphatase 22

1

7

High-throughput

0.437

High

708533

RELCH
RAB11-binding protein RELCH

1

2

High-throughput

0.437

High

708399

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

708469

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

2

Small-scale

0.407

High

708484

NECP1
Adaptin ear-binding coat-associated protein 1

1

0

High-throughput

0.279

Low

708497

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

708467

FBX46
F-box only protein 46

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024