Protein: RS27L
Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like)

Gene: RS27L, RPS27L
Organism: Homo sapiens
Interactions: 167
UniProt ID: Q71UM5

Gene Ontology (top 5):
GO:0000028 - ribosomal small subunit assembly
GO:0003723 - RNA binding
GO:0003735 - structural constituent of ribosome
GO:0005634 - nucleus
GO:0006412 - translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

967475

RS7
Small ribosomal subunit protein eS7

6

5

High-throughput

0.724

High

372387

MYC
Myc proto-oncogene protein

3

3

High-throughput

0.656

High

447146

NPM
Nucleophosmin

2

2

High-throughput

0.628

High

1126965

RBM39
RNA-binding protein 39

2

1

High-throughput

0.611

High

1161122

MK06
Mitogen-activated protein kinase 6

2

4

High-throughput

0.601

High

1028253

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.589

High

1259666

ESR2
Estrogen receptor beta

2

4

High-throughput

0.588

High

396389

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

1259303

TBA1A
Tubulin alpha-1A chain

2

3

High-throughput

0.571

High

303582

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.536

High

431168

LA
Lupus La protein

1

3

High-throughput

0.536

High

445566

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.536

High

479433

SRP19
Signal recognition particle 19 kDa protein

1

1

High-throughput

0.536

High

581549

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

4

High-throughput

0.536

High

687257

HMGB2
High mobility group protein B2

1

1

High-throughput

0.536

High

785246

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.536

High

859332

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.536

High

886516

CTCF
Transcriptional repressor CTCF

1

1

High-throughput

0.536

High

897043

MAP2
Methionine aminopeptidase 2

1

2

High-throughput

0.536

High

933329

IF5
Eukaryotic translation initiation factor 5

1

2

High-throughput

0.536

High

939363

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

5

High-throughput

0.536

High

951227

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.536

High

969934

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

973482

RS11
Small ribosomal subunit protein uS17

1

3

High-throughput

0.536

High

985729

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.536

High

992818

RACK1
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.536

High

1016067

RL19
Large ribosomal subunit protein eL19

1

2

High-throughput

0.536

High

1089724

ILF3
Interleukin enhancer-binding factor 3

1

2

High-throughput

0.536

High

1100854

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.536

High

1118897

BYST
Bystin

1

2

High-throughput

0.536

High

1126449

CAPR1
Caprin-1

1

2

High-throughput

0.536

High

1179314

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

3

High-throughput

0.536

High

1259663

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

1259675

RBM42
RNA-binding protein 42

1

4

High-throughput

0.536

High

1259683

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

1

High-throughput

0.536

High

1259691

SMYD2
N-lysine methyltransferase SMYD2

1

1

High-throughput

0.536

High

1259697

SRP68
Signal recognition particle subunit SRP68

1

2

High-throughput

0.536

High

1259698

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.536

High

1259703

G3BP2
Ras GTPase-activating protein-binding protein 2

1

4

High-throughput

0.536

High

1259706

DRG1
Developmentally-regulated GTP-binding protein 1

1

4

High-throughput

0.536

High

631305

RAB5A
Ras-related protein Rab-5A

2

2

High-throughput

0.521

High

542557

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

854130

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

884135

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

1152124

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

1259692

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

1259702

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

0

High-throughput

0.513

High

832067

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

7

High-throughput

0.489

High

867233

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.489

High

1259673

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

6

High-throughput

0.489

High

60154

HFM1
Probable ATP-dependent DNA helicase HFM1

1

4

High-throughput

0.481

High

1259657

CLIP4
CAP-Gly domain-containing linker protein 4

1

1

High-throughput

0.481

High

132119

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

157534

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

176075

KDM6B
Lysine-specific demethylase 6B

1

2

Small-scale

0.479

High

216097

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

2

High-throughput

0.479

High

223141

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

242089

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

315718

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

324945

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

331078

KI20A
Kinesin-like protein KIF20A

1

4

High-throughput

0.479

High

343264

ERR2
Steroid hormone receptor ERR2

1

4

High-throughput

0.479

High

345989

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

406313

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

472841

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.479

High

521384

ARAF
Serine/threonine-protein kinase A-Raf

1

2

High-throughput

0.479

High

537393

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

563968

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.479

High

683478

IKBA
NF-kappa-B inhibitor alpha

1

6

High-throughput

0.479

High

684283

DDX6
Probable ATP-dependent RNA helicase DDX6

1

4

High-throughput

0.479

High

766650

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

822730

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

830957

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

879212

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

888149

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

934778

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

969638

RS15A
Small ribosomal subunit protein uS8

1

3

High-throughput

0.479

High

970691

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

980870

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1035719

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

1088411

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

2

High-throughput

0.479

High

1098805

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

5

High-throughput

0.479

High

1109556

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

1

High-throughput

0.479

High

1109584

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

1

High-throughput

0.479

High

1109841

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.479

High

1137806

TNIP1
TNFAIP3-interacting protein 1

1

4

High-throughput

0.479

High

1194170

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

1197629

MIDN
Midnolin

1

1

High-throughput

0.479

High

1254359

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1259652

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.479

High

1259653

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1259654

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

1

2

High-throughput

0.479

High

1259655

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

1259656

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

1259662

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1259665

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1259667

KAT6A
Histone acetyltransferase KAT6A

1

4

High-throughput

0.479

High

1259668

PF21A
PHD finger protein 21A

1

4

High-throughput

0.479

High

1259671

RNF31
E3 ubiquitin-protein ligase RNF31

1

3

High-throughput

0.479

High

1259672

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1259678

TRI55
Tripartite motif-containing protein 55

1

6

High-throughput

0.479

High

1259679

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

1259680

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

1259685

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1259687

RC3H2
Roquin-2

1

3

High-throughput

0.479

High

1259693

AATF
Protein AATF

1

2

High-throughput

0.479

High

1259694

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1259696

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1259708

TRI17
E3 ubiquitin-protein ligase TRIM17

1

1

Small-scale

0.479

High

1259709

RBM8A
RNA-binding protein 8A

1

2

High-throughput

0.479

High

1259711

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.479

High

1152333

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

1

0

High-throughput

0.460

High

129204

MEN1
Menin

1

0

High-throughput

0.458

High

317871

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

904862

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

1095269

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

1140466

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1229539

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1238428

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

1259660

LNX1
E3 ubiquitin-protein ligase LNX

1

0

Small-scale

0.458

High

1259670

SPDLY
Protein Spindly

1

0

High-throughput

0.458

High

1259676

REPI1
DNA-binding protein REPIN1

1

0

High-throughput

0.458

High

1259690

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1259699

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

430069

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

516543

CALM3
Calmodulin-3

1

4

High-throughput

0.445

High

1259686

LN28A
Protein lin-28 homolog A

1

1

High-throughput

0.445

High

1259700

AGO2
Protein argonaute-2

1

2

High-throughput

0.445

High

1259701

AGO1
Protein argonaute-1

1

2

High-throughput

0.445

High

293911

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

353410

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

377624

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

378127

TNFA
Tumor necrosis factor

1

1

High-throughput

0.437

High

630304

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

2

High-throughput

0.437

High

641618

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

3

High-throughput

0.437

High

786146

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.437

High

1156981

NTRK3
NT-3 growth factor receptor

1

2

High-throughput

0.437

High

1158396

CDC37
Hsp90 co-chaperone Cdc37

1

1

High-throughput

0.437

High

1225365

WAC2A
WASH complex subunit 2A

1

1

High-throughput

0.437

High

1259659

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.437

High

1259661

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.437

High

1259664

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.437

High

1259669

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.437

High

1259674

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

3

High-throughput

0.437

High

1259681

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.437

High

1259682

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1259689

ANLN
Anillin

1

1

High-throughput

0.437

High

1259705

SIGL7
Sialic acid-binding Ig-like lectin 7

1

3

High-throughput

0.437

High

1259707

ASB4
Ankyrin repeat and SOCS box protein 4

1

4

High-throughput

0.437

High

143451

E2F3
Transcription factor E2F3

1

0

Small-scale

0.426

High

530001

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

1259688

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

0

Small-scale

0.426

High

943978

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.407

High

1023816

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.407

High

1259677

TX101
Testis-expressed protein 101

1

1

High-throughput

0.407

High

158576

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

0

High-throughput

0.279

Low

1120462

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

1259684

DCR1B
5' exonuclease Apollo

1

0

High-throughput

0.279

Low

136922

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.249

Low

139908

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

173968

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.249

Low

1259658

CC020
Uncharacterized protein C3orf20

1

0

High-throughput

0.249

Low

1259704

HPS5
BLOC-2 complex member HPS5

1

0

High-throughput

0.249

Low

1034490

TAGL
Transgelin

1

0

High-throughput

0.232

Low

1253259

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.232

Low

1259695

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.232

Low

1259710

S22A7
Solute carrier family 22 member 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025