Interactor 1: TNF10 (P50591)
Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)
Gene: TNFSF10
Interactor 2: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 0.60 | 0.760 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 23142077, 25551360, 19432816, 16554480, 22266862, 22585859, 21822306, 24287696, 16801533, 10894161, 19427028, 12198154, 10894160, 20097879, 21525171, 21459798, 23678861 |
| Identification Methods | affinity chromatography technology, anti tag coimmunoprecipitation, coimmunoprecipitation, pull down |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005164 - tumor necrosis factor receptor binding GO:0006915 - apoptotic process GO:0043065 - positive regulation of apoptotic process GO:0043123 - positive regulation of canonical NF-kappaB signal transduction |
| Homologous interactions | 13 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
