HitPredict

Interactor 1: FXR2 (P51116)
RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2)
Gene: FXR2

Interactor 2: KCC2G (Q13555)
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)
Gene: CAMK2G

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	29395067, 21653829
Identification Methods	proximity labelling technology, two hybrid, two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0042803 - protein homodimerization activity GO:0043005 - neuron projection
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 673 Hs			1 558
+	Mm
		659455 FXR1_MOUSE (14-673): 0: 981: 62.83		KCC2B_MOUSE (1-558): 0: 616: 77.23
+	Mm
		515232 FXR1_MOUSE (14-673): 0: 981: 62.83		KCC2A_MOUSE (1-555): 0: 551: 66.85
+	Hs
		844047 FXR2_HUMAN (1-673): 0: 1004: 100.00		KCC2D_HUMAN (1-558): 0: 525: 64.88
+	Hs
		843655 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2G_HUMAN (1-558): 0: 672: 100.00
+	Hs
		843969 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2A_HUMAN (1-555): 0: 550: 65.23
+	Mm
		1207083 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2G_MOUSE (1-558): 0: 643: 94.62
+	Mm
		659466 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2B_MOUSE (1-558): 0: 616: 77.23
+	Hs
		844045 FXR2_HUMAN (1-673): 0: 1004: 100.00		KCC2B_HUMAN (287-558): 1.59e-57: 205: 49.29
+	Mm
		515247 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2A_MOUSE (1-555): 0: 551: 66.85
+	Mm
		1161535 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2D_MOUSE (1-558): 0: 525: 64.88
+	Hs
		843654 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2B_HUMAN (287-558): 1.59e-57: 205: 49.29
+	Mm
		729581 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2G_MOUSE (1-558): 0: 643: 94.62
+	Mm
		659445 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2B_MOUSE (1-558): 0: 616: 77.23
+	Mm
		515218 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2A_MOUSE (1-555): 0: 551: 66.85
+	Hs
		989201 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		KCC2A_HUMAN (1-555): 0: 550: 65.23
+	Mm
		729519 FMR1_MOUSE (229-475): 4.6e-46: 174: 34.20		KCC2D_MOUSE (1-558): 0: 525: 64.88
+	Hs
		159196 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		CSKP_HUMAN (10-308): 2.84e-83: 280: 46.08
+	Hs
		988863 FMR1_HUMAN (310-475): 6.11e-45: 172: 41.42		KCC2B_HUMAN (287-558): 1.59e-57: 205: 49.29