Protein: MK01
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)

Gene: MK01, Mapk1
Organism: Mus musculus
Interactions: 83
UniProt ID: P63085

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001784 - phosphotyrosine residue binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

989559

KSR1
Kinase suppressor of Ras 1

6

14

Small-scale

0.934

High

989563

SQSTM
Sequestosome-1

2

6

Small-scale

0.799

High

989555

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

9

High-throughput

0.789

High

728903

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

20

Small-scale

0.778

High

147990

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

2

20

Small-scale

0.726

High

989573

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

2

20

Small-scale

0.726

High

989550

DUSP2
Dual specificity protein phosphatase 2

1

20

Small-scale

0.724

High

989560

PEA15
Astrocytic phosphoprotein PEA-15

1

4

Small-scale

0.724

High

989580

PAXI
Paxillin

4

8

Small-scale

0.699

High

989545

TNIK
Traf2 and NCK-interacting protein kinase

1

7

High-throughput

0.691

High

989553

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

5

High-throughput

0.691

High

989542

MK01
Mitogen-activated protein kinase 1

1

17

Small-scale

0.690

High

989561

DLG4
Disks large homolog 4

3

9

High-throughput

0.667

High

989562

PTPRR
Receptor-type tyrosine-protein phosphatase R

3

20

Small-scale

0.665

High

837019

ELK1
ETS domain-containing protein Elk-1

3

19

Small-scale

0.655

High

989587

DUS6
Dual specificity protein phosphatase 6

1

20

Small-scale

0.653

High

616115

KS6A3
Ribosomal protein S6 kinase alpha-3

1

20

Small-scale

0.647

High

989574

DJC27
DnaJ homolog subfamily C member 27

1

1

Small-scale

0.647

High

669409

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

3

Small-scale

0.619

High

411150

ARAF
Serine/threonine-protein kinase A-Raf

1

14

Small-scale

0.618

High

462108

HS90A
Heat shock protein HSP 90-alpha

1

19

Small-scale

0.618

High

772090

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

10

Small-scale

0.618

High

915278

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

7

High-throughput

0.618

High

989544

FER
Tyrosine-protein kinase Fer

1

5

Small-scale

0.618

High

989576

VRK3
Serine/threonine-protein kinase VRK3

1

20

Small-scale

0.618

High

989586

DUS3
Dual specificity protein phosphatase 3

1

20

Small-scale

0.618

High

989585

DLGP1
Disks large-associated protein 1

2

1

High-throughput

0.611

High

408244

MBP
Myelin basic protein

2

6

Small-scale

0.602

High

599650

ATF2
Cyclic AMP-dependent transcription factor ATF-2

2

17

Small-scale

0.602

High

989549

ZEP1
Zinc finger protein 40

1

2

High-throughput

0.590

High

989557

KLF4
Krueppel-like factor 4

1

8

Small-scale

0.590

High

989592

KS6A4
Ribosomal protein S6 kinase alpha-4

1

20

High-throughput

0.590

High

989566

TRPV1
Transient receptor potential cation channel subfamily V member 1

1

0

High-throughput

0.586

High

989577

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.586

High

857018

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

2

Small-scale

0.575

High

989552

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

2

Small-scale

0.575

High

989570

NANOG
Homeobox protein NANOG

1

2

Small-scale

0.573

High

989582

Q99K94
Signal transducer and activator of transcription

1

5

Small-scale

0.561

High

104498

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

8

High-throughput

0.536

High

771451

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

3

High-throughput

0.536

High

989569

MYOME
Myomegalin

1

3

High-throughput

0.536

High

266859

ITB5
Integrin beta-5

1

2

Small-scale

0.527

High

700393

CEBPB
CCAAT/enhancer-binding protein beta

1

16

Small-scale

0.516

High

989581

EED
Polycomb protein EED

1

4

High-throughput

0.515

High

932611

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

20

Small-scale

0.501

High

989543

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

4

Small-scale

0.501

High

989558

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

4

Small-scale

0.501

High

989589

ITA2B
Integrin alpha-IIb

1

3

High-throughput

0.501

High

108602

G3X9H5
Huntingtin

1

1

High-throughput

0.479

High

147382

CAN2
Calpain-2 catalytic subunit

1

2

Small-scale

0.479

High

148047

MAP2
Methionine aminopeptidase 2

1

2

Small-scale

0.479

High

205014

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

5

High-throughput

0.479

High

205744

PER1
Period circadian protein homolog 1

1

4

Small-scale

0.479

High

236748

PER2
Period circadian protein homolog 2

1

4

Small-scale

0.479

High

530772

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.479

High

989546

CRY1
Cryptochrome-1

1

1

Small-scale

0.479

High

989547

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

3

High-throughput

0.479

High

989548

TOP2A
DNA topoisomerase 2-alpha

1

2

Small-scale

0.479

High

989551

PECA1
Platelet endothelial cell adhesion molecule

1

5

Small-scale

0.479

High

989554

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

3

High-throughput

0.479

High

989556

SRC8
Src substrate cortactin

1

3

Small-scale

0.479

High

989565

NEB2
Neurabin-2

1

7

High-throughput

0.479

High

989572

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.479

High

989588

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

5

Small-scale

0.479

High

989590

BLNK
B-cell linker protein

1

2

Small-scale

0.479

High

989591

CRY2
Cryptochrome-2

1

1

Small-scale

0.479

High

884494

PCY1A
Choline-phosphate cytidylyltransferase A

1

0

Small-scale

0.458

High

927684

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

989567

FACD2
Fanconi anemia group D2 protein homolog

1

0

High-throughput

0.458

High

989583

CKLF3
CKLF-like MARVEL transmembrane domain-containing protein 3

1

0

Small-scale

0.458

High

989568

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.457

High

989575

CROCC
Rootletin

1

2

High-throughput

0.457

High

989579

ZMY11
Zinc finger MYND domain-containing protein 11

1

2

High-throughput

0.457

High

607329

GATA1
Erythroid transcription factor

1

4

Small-scale

0.445

High

777850

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.445

High

989564

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.438

High

989571

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

1

High-throughput

0.437

High

915526

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.426

High

989578

NUP58
Nucleoporin p58/p45

1

2

High-throughput

0.417

High

989584

Q9D318
GRAM domain-containing protein

1

1

High-throughput

0.417

High

204777

EFNB3
Ephrin-B3

1

0

Small-scale

0.249

Low

398292

CFAD
Complement factor D

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025