HitPredict

Interactor 1: DVL1 (P51141)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: SMAD1 (P70340)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1)
Gene: SMAD1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12650946
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019901 - protein kinase binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 695 Mm			1 465
+	Hs
		150710 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD1_HUMAN (1-465): 0: 653: 99.14
+	Mm
		844423 DVL1_MOUSE (1-695): 0: 602: 100.00		SMAD2_MOUSE (3-465): 0: 539: 55.14
+	Hs
		150693 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD3_HUMAN (3-465): 0: 554: 59.44
+	Hs
		150709 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD2_HUMAN (3-465): 0: 537: 55.14
+	Mm
		844412 DVL1_MOUSE (1-695): 0: 602: 100.00		SMAD4_MOUSE (8-454): 6.82e-151: 442: 33.33
+	Hs
		150701 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD4_HUMAN (8-454): 1.16e-150: 441: 33.15
+	Hs
		150947 DVL2_HUMAN (3-695): 2.79e-147: 448: 57.75		SMAD3_HUMAN (3-465): 0: 554: 59.44
+	Hs
		1078732 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD1_HUMAN (1-465): 0: 653: 99.14
+	Hs
		950226 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD3_HUMAN (3-465): 0: 554: 59.44
+	Hs
		1078635 NEB2_HUMAN (58-423): 2.41e-51: 193: 16.22		SMAD2_HUMAN (3-465): 0: 537: 55.14
+	Hs
		1078579 RIMS1_HUMAN (8-655): 1.32e-45: 178: 14.63		SMAD2_HUMAN (3-465): 0: 537: 55.14
+	Hs
		1078596 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD2_HUMAN (3-465): 0: 537: 55.14
+	Mm
		192484 DVL1_MOUSE (1-695): 0: 602: 100.00		SMAD7_MOUSE (30-131): 1.02e-24: 107: 33.33
+	Hs
		150650 DVL1_HUMAN (1-695): 0: 569: 94.83		SMAD7_HUMAN (30-131): 2.87e-25: 109: 32.46
+	Mm
		1207311 MAGI2_MOUSE (117-387): 7.01e-19: 93.7: 11.44		SMAD3_MOUSE (3-465): 0: 554: 59.44
+	Hs
		1035517 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD4_HUMAN (8-454): 1.16e-150: 441: 33.15
+	Hs
		167376 PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45		SMAD7_HUMAN (30-131): 2.87e-25: 109: 32.46