HitPredict

Interactor 1: RAB5C (P51148)
Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Gene: RAB5C

Interactor 2: RABX5 (Q9UJ41)
Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5)
Gene: RABGEF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~VPS9
Common GO terms	GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 491
+	Hs
		592565 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		RABX5_HUMAN (1-491): 0: 563: 100.00
+	Hs
		914438 RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25		RABX5_HUMAN (1-491): 0: 563: 100.00
+	Hs
		1355935 RB22A_HUMAN (21-214): 1.25e-61: 192: 47.94		RABX5_HUMAN (1-491): 0: 563: 100.00
+	Dm
		1358752 RAB5_DROME (2-214): 2.73e-99: 288: 74.65		Q9W0H9_DROME (1-470): 4.91e-143: 428: 33.27
+	Ce
		954788 P91857_CAEEL (1-214): 1.12e-87: 258: 72.90		Q8I100_CAEEL (4-476): 3.7e-125: 376: 29.88
+	Hs
		844638 RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10
+	Hs
		1137131 Q5U0I6_HUMAN (12-214): 1.9e-93: 273: 41.18		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10
+	Hs
		918912 RAB1A_HUMAN (12-214): 1.9e-93: 273: 41.18		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10
+	Hs
		592390 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10
+	Hs
		72912 B4DMN1_HUMAN (8-216): 2.84e-88: 262: 38.99		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10
+	Hs
		895368 RAB5B_HUMAN (1-216): 1.1e-87: 259: 84.26		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10
+	At
		1339601 RAF2B_ARATH (14-215): 3.06e-79: 237: 62.56		VPS9A_ARATH (142-474): 7.04e-83: 267: 24.20
+	Ce
		954790 P91857_CAEEL (1-214): 1.12e-87: 258: 72.90		RME6_CAEEL (40-369): 8.48e-70: 242: 21.66
+	Dm
		1228833 RAB5_DROME (2-214): 2.73e-99: 288: 74.65		SPRI_DROME (128-454): 2.47e-58: 210: 14.21
+	Hs
		592407 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		RIN2_HUMAN (140-489): 3.26e-60: 214: 14.91
+	Hs
		895371 RAB5B_HUMAN (1-216): 1.1e-87: 259: 84.26		RIN2_HUMAN (140-489): 3.26e-60: 214: 14.91
+	Sc
		731194 VPS21_YEAST (19-215): 9.7e-64: 198: 54.15		VPS9_YEAST (119-482): 2.98e-86: 274: 23.89
+	Hs
		592240 RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57		RIN1_HUMAN (81-444): 7.83e-58: 206: 13.44
+	Hs
		895350 RAB5B_HUMAN (1-216): 1.1e-87: 259: 84.26		RIN1_HUMAN (81-444): 7.83e-58: 206: 13.44
+	Hs
		1120221 Q53EY4_HUMAN (19-214): 1.75e-59: 187: 46.43		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10