HitPredict - High confidence protein-protein interactions

Interactor 1: EAA2 (P43006)
Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
Gene: Slc1a2

Interactor 2: EAA2 (P43006)
Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
Gene: Slc1a2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	19201818
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SDF~SDF
Common GO terms	GO:0005313 - L-glutamate transmembrane transporter activity GO:0005314 - high-affinity L-glutamate transmembrane transporter activity GO:0005886 - plasma membrane GO:0006750 - glutathione biosynthetic process GO:0007399 - nervous system development and 34 others more... GO:0007632 - visual behavior GO:0008509 - monoatomic anion transmembrane transporter activity GO:0009410 - response to xenobiotic stimulus GO:0009416 - response to light stimulus GO:0009611 - response to wounding GO:0009986 - cell surface GO:0015501 - glutamate:sodium symporter activity GO:0015813 - L-glutamate transmembrane transport GO:0016020 - membrane GO:0021537 - telencephalon development GO:0030424 - axon GO:0030534 - adult behavior GO:0030673 - axolemma GO:0031982 - vesicle GO:0033229 - cysteine transmembrane transporter activity GO:0035264 - multicellular organism growth GO:0042734 - presynaptic membrane GO:0043200 - response to amino acid GO:0044297 - cell body GO:0044306 - neuron projection terminus GO:0045121 - membrane raft GO:0045202 - synapse GO:0046326 - positive regulation of D-glucose import GO:0046872 - metal ion binding GO:0070207 - protein homotrimerization GO:0070779 - D-aspartate import across plasma membrane GO:0071314 - cellular response to cocaine GO:0097449 - astrocyte projection GO:0098656 - monoatomic anion transmembrane transport GO:0098712 - L-glutamate import across plasma membrane GO:0098796 - membrane protein complex GO:0098810 - neurotransmitter reuptake GO:0098978 - glutamatergic synapse GO:0140009 - L-aspartate import across plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1	572
Mm

1	572

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Last updated: 11Aug2025