Protein: EAA4
Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6)

Gene: EAA4, SLC1A6
Organism: Homo sapiens
Interactions: 55
UniProt ID: P48664

Gene Ontology (top 5):
GO:0001504 - neurotransmitter uptake
GO:0005313 - L-glutamate transmembrane transporter activity
GO:0005314 - high-affinity L-glutamate transmembrane transporter activity
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

844736

EAA1
Excitatory amino acid transporter 1

1

10

High-throughput

0.575

High

876451

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

175331

PLXB2
Plexin-B2

1

2

High-throughput

0.445

High

336639

BAG4
BAG family molecular chaperone regulator 4

1

1

High-throughput

0.445

High

439679

INSR
Insulin receptor

1

13

High-throughput

0.445

High

465452

IGF1R
Insulin-like growth factor 1 receptor

1

16

High-throughput

0.445

High

543093

UBL4A
Ubiquitin-like protein 4A

1

2

High-throughput

0.445

High

658868

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

4

High-throughput

0.445

High

699646

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

7

High-throughput

0.445

High

787123

BMR1A
Bone morphogenetic protein receptor type-1A

1

1

High-throughput

0.445

High

856583

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.445

High

876419

EPHB4
Ephrin type-B receptor 4

1

13

High-throughput

0.445

High

876420

EPHA4
Ephrin type-A receptor 4

1

14

High-throughput

0.445

High

876421

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

2

High-throughput

0.445

High

876422

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

4

High-throughput

0.445

High

876423

CASP
Protein CASP

1

1

High-throughput

0.445

High

876424

CP51A
Lanosterol 14-alpha demethylase

1

1

High-throughput

0.445

High

876426

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

3

High-throughput

0.445

High

876429

GHDC
GH3 domain-containing protein

1

1

High-throughput

0.445

High

876430

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

3

High-throughput

0.445

High

876432

GOGA5
Golgin subfamily A member 5

1

1

High-throughput

0.445

High

876434

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

1

High-throughput

0.445

High

876438

OSMR
Oncostatin-M-specific receptor subunit beta

1

6

High-throughput

0.445

High

876442

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

6

High-throughput

0.445

High

876443

WDR6
tRNA

1

5

High-throughput

0.445

High

876444

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

3

High-throughput

0.445

High

876447

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.445

High

876448

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

1

2

High-throughput

0.445

High

876450

NISCH
Nischarin

1

3

High-throughput

0.445

High

876452

DAAM1
Disheveled-associated activator of morphogenesis 1

1

4

High-throughput

0.445

High

876453

LRP12
Low-density lipoprotein receptor-related protein 12

1

1

High-throughput

0.445

High

50513

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

155446

C2C2L
Phospholipid transfer protein C2CD2L

1

0

High-throughput

0.426

High

243790

ADCY3
Adenylate cyclase type 3

1

0

High-throughput

0.426

High

287536

LRP6
Low-density lipoprotein receptor-related protein 6

1

0

High-throughput

0.426

High

679097

DNJB1
DnaJ homolog subfamily B member 1

1

0

High-throughput

0.426

High

761346

HS71L
Heat shock 70 kDa protein 1-like

1

0

High-throughput

0.426

High

876427

SIM29
Small integral membrane protein 29

1

0

High-throughput

0.426

High

876431

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.426

High

876437

NEUR1
Sialidase-1

1

0

High-throughput

0.426

High

876439

ABCA3
Phospholipid-transporting ATPase ABCA3

1

0

High-throughput

0.426

High

876441

SEM4C
Semaphorin-4C

1

0

High-throughput

0.426

High

136335

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

7

High-throughput

0.407

High

343915

HS74L
Heat shock 70 kDa protein 4L

1

1

High-throughput

0.407

High

399669

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

1

High-throughput

0.407

High

876428

DAAM2
Disheveled-associated activator of morphogenesis 2

1

4

High-throughput

0.407

High

876433

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

6

High-throughput

0.407

High

876436

SRAC1
Protein SERAC1

1

3

High-throughput

0.407

High

876440

CYBC1
Cytochrome b-245 chaperone 1

1

1

High-throughput

0.407

High

876446

DJC12
DnaJ homolog subfamily C member 12

1

1

High-throughput

0.407

High

876449

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.407

High

335036

ARI2
E3 ubiquitin-protein ligase ARIH2

1

0

High-throughput

0.282

High

876425

VP13C
Intermembrane lipid transfer protein VPS13C

1

0

High-throughput

0.232

Low

876435

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.232

Low

876445

TRM7
tRNA

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025