HitPredict

Interactor 1: RORG (P51449)
Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma)
Gene: RORC

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34135062
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 518 Hs			1 1424
+	Hs
		130340 NR5A2_HUMAN (24-502): 7.37e-100: 313: 19.26		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		265886 NR1I2_HUMAN (9-511): 2.29e-97: 303: 24.41		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Mm
		985522 RORB_MOUSE (13-509): 3.01e-124: 373: 44.69		Q05BA5_MOUSE (1-1424): 1.37e-137: 460: 80.73
+	Hs
		846423 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		NPAS2_HUMAN (19-807): 7.51e-111: 372: 16.20
+	Mm
		60493 RORB_MOUSE (13-509): 3.01e-124: 373: 44.69		A5D6Q2_MOUSE (50-1424): 1.18e-129: 437: 80.69
+	Hs
		846420 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		BMAL2_HUMAN (10-541): 1.06e-108: 360: 16.06
+	Hs
		126112 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Mm
		846435 RORG_MOUSE (1-518): 1.51e-142: 422: 88.61		HIF1A_MOUSE (1-772): 2.12e-109: 368: 14.29
+	Hs
		723182 RORA_HUMAN (6-516): 7.11e-126: 379: 47.95		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		181506 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		846416 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		130327 NR5A2_HUMAN (24-502): 7.37e-100: 313: 19.26		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		723179 RORA_HUMAN (6-516): 7.11e-126: 379: 47.95		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		265869 NR1I2_HUMAN (9-511): 2.29e-97: 303: 24.41		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		1078516 Q58EY0_HUMAN (22-509): 2.27e-123: 370: 45.10		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		181531 Q58EY0_HUMAN (22-509): 2.27e-123: 370: 45.10		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Dm
		247694 E78C_DROME (30-515): 8.17e-90: 295: 24.16		CYCL_DROME (5-369): 9.83e-105: 341: 20.72
+	Hs
		181523 NR1D2_HUMAN (1-488): 1.19e-106: 331: 28.54		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		130328 NR5A2_HUMAN (24-502): 7.37e-100: 313: 19.26		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		265870 NR1I2_HUMAN (9-511): 2.29e-97: 303: 24.41		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53