Protein: CRBN
Protein cereblon

Gene: CRBN
Organism: Homo sapiens
Interactions: 203
UniProt ID: Q96SW2

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016020 - membrane
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1157883

DDB1
DNA damage-binding protein 1

22

1

Small-scale

0.987

High

1104653

IKZF1
DNA-binding protein Ikaros

14

1

Small-scale

0.982

High

1403146

SALL4
Sal-like protein 4

7

2

Small-scale

0.966

High

1403148

IKZF3
Zinc finger protein Aiolos

6

1

Small-scale

0.947

High

876975

KC1A
Casein kinase I isoform alpha

6

0

Small-scale

0.913

High

1395474

ZFP91
E3 ubiquitin-protein ligase ZFP91

3

1

Small-scale

0.840

High

1403140

PAK5
Serine/threonine-protein kinase PAK 5

2

0

High-throughput

0.769

High

1115016

CUL4A
Cullin-4A

16

2

Small-scale

0.762

High

1095448

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

2

0

Small-scale

0.759

High

401343

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

2

Small-scale

0.754

High

1115375

CUL4B
Cullin-4B

8

2

Small-scale

0.749

High

983949

RBX1
E3 ubiquitin-protein ligase RBX1

8

0

Small-scale

0.714

High

581576

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

0

Small-scale

0.708

High

1051408

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

Small-scale

0.708

High

906755

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

1

Small-scale

0.688

High

1272532

CSN6
COP9 signalosome complex subunit 6

5

0

Small-scale

0.673

High

1370314

CSN5
COP9 signalosome complex subunit 5

3

1

Small-scale

0.656

High

334580

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

6

Small-scale

0.647

High

613149

EGR1
Early growth response protein 1

1

1

Small-scale

0.647

High

832776

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.647

High

1127703

HIC1
Hypermethylated in cancer 1 protein

1

1

Small-scale

0.647

High

1324507

OSR2
Protein odd-skipped-related 2

1

1

Small-scale

0.647

High

1347771

OSR1
Protein odd-skipped-related 1

1

1

Small-scale

0.647

High

1394767

HIC2
Hypermethylated in cancer 2 protein

1

3

Small-scale

0.647

High

1403129

SALL3
Sal-like protein 3

1

2

Small-scale

0.647

High

1403137

SALL1
Sal-like protein 1

1

2

Small-scale

0.647

High

167371

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.630

High

1307242

TF2LY
Homeobox protein TGIF2LY

2

1

High-throughput

0.628

High

920216

PLK1
Serine/threonine-protein kinase PLK1

1

1

Small-scale

0.618

High

1403130

GZF1
GDNF-inducible zinc finger protein 1

1

0

Small-scale

0.614

High

1219141

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

2

0

High-throughput

0.602

High

1239920

CAVN1
Caveolae-associated protein 1

2

0

High-throughput

0.602

High

163465

MEIS2
Homeobox protein Meis2

2

1

Small-scale

0.595

High

170302

AURKA
Aurora kinase A

1

0

High-throughput

0.586

High

891753

GSK3B
Glycogen synthase kinase-3 beta

1

0

Small-scale

0.586

High

1144300

STK38
Serine/threonine-protein kinase 38

1

0

Small-scale

0.586

High

1403120

CSN8
COP9 signalosome complex subunit 8

2

0

Small-scale

0.585

High

461847

HS90A
Heat shock protein HSP 90-alpha

2

1

Small-scale

0.584

High

1403151

CSN3
COP9 signalosome complex subunit 3

2

2

Small-scale

0.584

High

180169

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

3

Small-scale

0.579

High

1050839

EGR4
Early growth response protein 4

1

2

Small-scale

0.579

High

1322878

BCL6B
B-cell CLL/lymphoma 6 member B protein

1

1

Small-scale

0.579

High

1337794

DP13B
DCC-interacting protein 13-beta

2

1

High-throughput

0.576

High

700946

PSB4
Proteasome subunit beta type-4

1

1

Small-scale

0.573

High

958700

CSN2
COP9 signalosome complex subunit 2

2

2

Small-scale

0.571

High

965838

HNRPK
Heterogeneous nuclear ribonucleoprotein K

2

0

Small-scale

0.569

High

987882

GRB2
Growth factor receptor-bound protein 2

2

0

High-throughput

0.569

High

422951

A4
Amyloid-beta precursor protein

2

1

Small-scale

0.563

High

414464

P53
Cellular tumor antigen p53

1

2

Small-scale

0.561

High

578536

BRAF
Serine/threonine-protein kinase B-raf

1

2

Small-scale

0.561

High

1403147

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.560

High

430260

JUN
Transcription factor Jun

2

0

Small-scale

0.559

High

1403125

CSN4
COP9 signalosome complex subunit 4

2

0

Small-scale

0.559

High

1403157

FBX7
F-box only protein 7

2

0

Small-scale

0.559

High

1142635

PDK1
[Pyruvate dehydrogenase

2

1

High-throughput

0.558

High

1403126

ZN692
Zinc finger protein 692

1

1

Small-scale

0.553

High

1364860

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

0

High-throughput

0.551

High

1372043

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.549

High

547336

CP19A
Aromatase

1

0

Small-scale

0.537

High

578704

GLNA
Glutamine synthetase

1

0

Small-scale

0.537

High

727934

DNJA1
DnaJ homolog subfamily A member 1

1

0

Small-scale

0.537

High

774571

BASI
Basigin

1

0

Small-scale

0.537

High

925589

MOT1
Monocarboxylate transporter 1

1

0

Small-scale

0.537

High

931072

HSP72
Heat shock-related 70 kDa protein 2

1

0

Small-scale

0.537

High

1108068

SQSTM
Sequestosome-1

1

0

Small-scale

0.537

High

1403142

ZMYM2
Zinc finger MYM-type protein 2

1

0

Small-scale

0.537

High

771956

CLCN1
Chloride channel protein 1

2

3

Small-scale

0.533

High

564258

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

686857

S10A4
Protein S100-A4

1

0

High-throughput

0.513

High

1371182

GLMN
Glomulin

1

0

High-throughput

0.513

High

930354

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

1

Small-scale

0.501

High

957175

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

1

Small-scale

0.501

High

970224

UB2G1
Ubiquitin-conjugating enzyme E2 G1

1

2

Small-scale

0.501

High

47404

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.493

High

216522

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.486

High

246887

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.486

High

344985

WIZ
Protein Wiz

1

0

Small-scale

0.480

High

687289

HMGB2
High mobility group protein B2

1

0

Small-scale

0.480

High

990638

1433Z
14-3-3 protein zeta/delta

1

0

Small-scale

0.480

High

1134343

IMB1
Importin subunit beta-1

1

0

Small-scale

0.480

High

1403141

HDAC6
Protein deacetylase HDAC6

1

0

Small-scale

0.480

High

1403150

ELF5
ETS-related transcription factor Elf-5

1

0

Small-scale

0.480

High

256673

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

1

Small-scale

0.479

High

359718

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

Small-scale

0.479

High

443933

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

1

Small-scale

0.479

High

449657

CALCA
Calcitonin gene-related peptide 1

1

1

High-throughput

0.479

High

462587

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

Small-scale

0.479

High

468719

HS90B
Heat shock protein HSP 90-beta

1

1

Small-scale

0.479

High

521419

ARAF
Serine/threonine-protein kinase A-Raf

1

2

Small-scale

0.479

High

549668

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

Small-scale

0.479

High

574437

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

Small-scale

0.479

High

576515

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

1

Small-scale

0.479

High

610841

TCPA
T-complex protein 1 subunit alpha

1

1

Small-scale

0.479

High

650920

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

1

Small-scale

0.479

High

680468

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

Small-scale

0.479

High

685694

U2AF2
Splicing factor U2AF 65 kDa subunit

1

4

Small-scale

0.479

High

775274

FUS
RNA-binding protein FUS

1

2

Small-scale

0.479

High

794595

RBMX
RNA-binding motif protein, X chromosome

1

3

Small-scale

0.479

High

799422

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

821519

TCPZ
T-complex protein 1 subunit zeta

1

1

Small-scale

0.479

High

846431

MATR3
Matrin-3

1

1

Small-scale

0.479

High

858802

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

1

Small-scale

0.479

High

876132

TCPE
T-complex protein 1 subunit epsilon

1

1

Small-scale

0.479

High

892609

DNLI3
DNA ligase 3

1

1

Small-scale

0.479

High

892717

DNLI4
DNA ligase 4

1

1

Small-scale

0.479

High

899185

TCPQ
T-complex protein 1 subunit theta

1

2

Small-scale

0.479

High

910643

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

2

Small-scale

0.479

High

954590

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

Small-scale

0.479

High

957481

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

960218

RL26
Large ribosomal subunit protein uL24

1

1

Small-scale

0.479

High

974024

RUXF
Small nuclear ribonucleoprotein F

1

1

Small-scale

0.479

High

974454

SMD1
Small nuclear ribonucleoprotein Sm D1

1

2

Small-scale

0.479

High

974823

SMD3
Small nuclear ribonucleoprotein Sm D3

1

2

Small-scale

0.479

High

991231

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

1

Small-scale

0.479

High

1094403

CSN1
COP9 signalosome complex subunit 1

1

1

Small-scale

0.479

High

1112670

CUL1
Cullin-1

1

2

Small-scale

0.479

High

1359074

SPRY4
SPRY domain-containing protein 4

1

1

Small-scale

0.479

High

1403121

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

1

Small-scale

0.479

High

1403124

PCGF1
Polycomb group RING finger protein 1

1

1

High-throughput

0.479

High

1403131

P63
Tumor protein 63

1

2

Small-scale

0.479

High

1403134

CSN7B
COP9 signalosome complex subunit 7b

1

1

Small-scale

0.479

High

1403143

CSN7A
COP9 signalosome complex subunit 7a

1

1

Small-scale

0.479

High

1403145

RABX5
Rab5 GDP/GTP exchange factor

1

1

Small-scale

0.479

High

1403153

RUVB2
RuvB-like 2

1

1

Small-scale

0.479

High

1403154

RUVB1
RuvB-like 1

1

1

Small-scale

0.479

High

1403159

TRAF6
TNF receptor-associated factor 6

1

1

Small-scale

0.479

High

64672

FA83G
Protein FAM83G

1

0

Small-scale

0.458

High

181160

AXIN1
Axin-1

1

0

Small-scale

0.458

High

214003

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

Small-scale

0.458

High

220410

LAT
Linker for activation of T-cells family member 1

1

0

Small-scale

0.458

High

242672

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

337014

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

347269

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.458

High

347881

BAG3
BAG family molecular chaperone regulator 3

1

0

Small-scale

0.458

High

446540

DPOLB
DNA polymerase beta

1

0

Small-scale

0.458

High

467586

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.458

High

476784

RSSA
Small ribosomal subunit protein uS2

1

0

Small-scale

0.458

High

528330

THIO
Thioredoxin

1

0

Small-scale

0.458

High

552674

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

Small-scale

0.458

High

569133

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.458

High

608712

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.458

High

617729

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.458

High

623498

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.458

High

642275

COMT
Catechol O-methyltransferase

1

0

Small-scale

0.458

High

652567

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

0

Small-scale

0.458

High

668700

APC
Adenomatous polyposis coli protein

1

0

Small-scale

0.458

High

681216

PSA2
Proteasome subunit alpha type-2

1

0

Small-scale

0.458

High

764981

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

842494

RL35
Large ribosomal subunit protein uL29

1

0

Small-scale

0.458

High

913562

KIF11
Kinesin-like protein KIF11

1

0

Small-scale

0.458

High

926219

ICLN
Methylosome subunit pICln

1

0

Small-scale

0.458

High

935032

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

959918

RS3A
Small ribosomal subunit protein eS1

1

0

Small-scale

0.458

High

961376

RL27
Large ribosomal subunit protein eL27

1

0

Small-scale

0.458

High

969379

RS8
Small ribosomal subunit protein eS8

1

0

Small-scale

0.458

High

983033

RS25
Small ribosomal subunit protein eS25

1

0

Small-scale

0.458

High

992310

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

1016579

SRSF3
Serine/arginine-rich splicing factor 3

1

0

Small-scale

0.458

High

1024786

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1027682

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

Small-scale

0.458

High

1033756

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1051515

SRS11
Serine/arginine-rich splicing factor 11

1

0

Small-scale

0.458

High

1085871

KCMA1
Calcium-activated potassium channel subunit alpha-1

1

0

Small-scale

0.458

High

1088731

SF3A3
Splicing factor 3A subunit 3

1

0

Small-scale

0.458

High

1089517

ILF2
Interleukin enhancer-binding factor 2

1

0

Small-scale

0.458

High

1102890

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

Small-scale

0.458

High

1119266

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

Small-scale

0.458

High

1247625

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

Small-scale

0.458

High

1271206

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.458

High

1275333

APTX
Aprataxin

1

0

Small-scale

0.458

High

1356725

TM263
Transmembrane protein 263

1

0

Small-scale

0.458

High

1387438

CMBL
Carboxymethylenebutenolidase homolog

1

0

Small-scale

0.458

High

1403122

MEP50
Methylosome protein WDR77

1

0

Small-scale

0.458

High

1403123

RIOK1
Serine/threonine-protein kinase RIO1

1

0

Small-scale

0.458

High

1403127

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

1

0

Small-scale

0.458

High

1403132

BOLA2
BolA-like protein 2

1

0

Small-scale

0.458

High

1403133

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1403135

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

1403136

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1403138

PIHD1
PIH1 domain-containing protein 1

1

0

Small-scale

0.458

High

1403139

DJB12
DnaJ homolog subfamily B member 12

1

0

Small-scale

0.458

High

1403149

AGO2
Protein argonaute-2

1

0

Small-scale

0.458

High

1403156

RTCB
RNA-splicing ligase RtcB homolog

1

0

Small-scale

0.458

High

1403158

3BP1
SH3 domain-binding protein 1

1

0

Small-scale

0.458

High

1403160

SPIN1
Spindlin-1

1

0

Small-scale

0.458

High

1403161

NS1BP
Influenza virus NS1A-binding protein

1

0

Small-scale

0.458

High

883472

DHE4
Glutamate dehydrogenase 2, mitochondrial

1

1

Small-scale

0.437

High

907686

CLCN2
Chloride channel protein 2

1

3

Small-scale

0.437

High

1127097

RBM39
RNA-binding protein 39

1

3

Small-scale

0.437

High

1388525

RMXL1
RNA binding motif protein, X-linked-like-1

1

4

Small-scale

0.437

High

1403144

PUF60
Poly(U)-binding-splicing factor PUF60

1

3

Small-scale

0.437

High

1403152

RL26L
Ribosomal protein uL24-like

1

1

Small-scale

0.437

High

530253

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

1401855

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

85101

B7Z207
Protein-serine/threonine kinase

1

1

High-throughput

0.407

High

377254

CALC
Calcitonin [Cleaved into: Calcitonin

1

1

High-throughput

0.407

High

699470

PROP
Properdin

2

0

High-throughput

0.328

High

1309145

MISP
Mitotic interactor and substrate of PLK1

2

0

High-throughput

0.316

High

1382685

COQA1
Collagen alpha-1(XXVI) chain

1

0

High-throughput

0.268

Low

1142374

PDIA6
Protein disulfide-isomerase A6

1

0

Small-scale

0.249

Low

1253104

KRBA2
KRAB-A domain-containing protein 2

1

0

Small-scale

0.249

Low

1403128

DDA1
DET1- and DDB1-associated protein 1

1

0

Small-scale

0.249

Low

1403155

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025