HitPredict

Interactor 1: SMCA4 (P51532)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: SMARCA4

Interactor 2: BRDT (Q58F21)
Bromodomain testis-specific protein (Cancer/testis antigen 9) (CT9) (RING3-like protein)
Gene: BRDT

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~Bromodomain
Common GO terms	GO:0000785 - chromatin GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0070577 - lysine-acetylated histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1647 Hs			1 947
+	Hs
		846977 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		BRD3_HUMAN (6-634): 4.42e-99: 328: 46.22
+	Hs
		846778 SMCA2_HUMAN (1-1647): 0: 980: 71.69		BRD3_HUMAN (6-634): 4.42e-99: 328: 46.22
+	Hs
		846947 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		EP300_HUMAN (2-292): 5.1e-37: 153: 19.26
+	Hs
		847041 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		CBP_HUMAN (8-304): 2.83e-36: 151: 20.46
+	Hs
		244139 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		BRD4_HUMAN (8-921): 1.04e-22: 107: 13.12
+	Hs
		631380 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		BRD2_HUMAN (225-928): 1.74e-22: 105: 15.23
+	Hs
		847113 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		ZMYD8_HUMAN (19-725): 1.16e-18: 93.7: 12.06
+	Hs
		847033 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		PHIP_HUMAN (29-184): 4.01e-17: 89.1: 21.38
+	Hs
		847007 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		PB1_HUMAN (11-161): 1.56e-14: 80.6: 17.83
+	Hs
		847093 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		BRWD1_HUMAN (40-188): 4.33e-13: 76: 18.00
+	Mm
		101533 SMCA4_MOUSE (1-1647): 0: 1069: 96.66		F8VQD1_MOUSE (11-740): 2.42e-15: 83.3: 10.78
+	Mm
		1111945 SMCA4_MOUSE (1-1647): 0: 1069: 96.66		PB1_MOUSE (11-161): 5.87e-15: 82.2: 17.83
+	Hs
		846760 SMCA2_HUMAN (1-1647): 0: 980: 71.69		EP300_HUMAN (2-292): 5.1e-37: 153: 19.26
+	Hs
		846837 SMCA2_HUMAN (1-1647): 0: 980: 71.69		CBP_HUMAN (8-304): 2.83e-36: 151: 20.46
+	Hs
		846838 SMCA2_HUMAN (1-1647): 0: 980: 71.69		KAT2B_HUMAN (230-375): 4.27e-27: 120: 26.03
+	Hs
		244138 SMCA2_HUMAN (1-1647): 0: 980: 71.69		BRD4_HUMAN (8-921): 1.04e-22: 107: 13.12
+	Hs
		631379 SMCA2_HUMAN (1-1647): 0: 980: 71.69		BRD2_HUMAN (225-928): 1.74e-22: 105: 15.23
+	Mm
		101535 SMCA2_MOUSE (40-1647): 0: 986: 72.73		F8VQD1_MOUSE (11-740): 2.42e-15: 83.3: 10.78
+	Hs
		846812 SMCA2_HUMAN (1-1647): 0: 980: 71.69		PB1_HUMAN (11-161): 1.56e-14: 80.6: 17.83
+	Dm
		115984 BRM_DROME (211-1642): 0: 858: 53.26		M9PH39_DROME (5-294): 2.22e-40: 164: 18.67