Protein: TRAF4
TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)

Gene: TRAF4
Organism: Homo sapiens
Interactions: 209
UniProt ID: Q9BUZ4

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0005164 - tumor necrosis factor receptor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1414771

TRAF4
TNF receptor-associated factor 4

6

18

Small-scale

0.958

High

543279

UBL4A
Ubiquitin-like protein 4A

4

20

High-throughput

0.904

High

1330535

UBL4B
Ubiquitin-like protein 4B

4

16

High-throughput

0.901

High

1331913

DTX3
Probable E3 ubiquitin-protein ligase DTX3

3

1

High-throughput

0.861

High

906764

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

20

Small-scale

0.845

High

1348471

LNX1
E3 ubiquitin-protein ligase LNX

3

20

Small-scale

0.843

High

1414800

UBQL2
Ubiquilin-2

3

14

High-throughput

0.843

High

1090891

TRAF2
TNF receptor-associated factor 2

3

17

Small-scale

0.827

High

1414812

TRAF6
TNF receptor-associated factor 6

2

18

Small-scale

0.819

High

572178

TRI27
Zinc finger protein RFP

2

19

High-throughput

0.783

High

610458

PRS6A
26S proteasome regulatory subunit 6A

7

11

Small-scale

0.747

High

572849

NCF1
Neutrophil cytosol factor 1

5

6

Small-scale

0.714

High

1414780

SMUF2
E3 ubiquitin-protein ligase SMURF2

4

15

Small-scale

0.707

High

1332026

BANP
Protein BANP

4

4

High-throughput

0.705

High

1230233

K1C40
Keratin, type I cytoskeletal 40

4

20

High-throughput

0.704

High

132275

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

4

15

High-throughput

0.703

High

1118973

BYST
Bystin

4

3

High-throughput

0.703

High

651426

CBL
E3 ubiquitin-protein ligase CBL

1

12

High-throughput

0.698

High

1414803

CBLC
E3 ubiquitin-protein ligase CBL-C

1

9

High-throughput

0.698

High

1414794

TBCD7
TBC1 domain family member 7

5

0

High-throughput

0.693

High

1272348

ATOSB
Atos homolog protein B

4

1

High-throughput

0.688

High

1371649

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

4

14

Small-scale

0.680

High

1414781

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

3

15

High-throughput

0.678

High

600514

ZNF3
Zinc finger protein 3

3

20

High-throughput

0.675

High

868243

SYQ
Glutamine--tRNA ligase

3

2

High-throughput

0.675

High

1146134

K1H1
Keratin, type I cuticular Ha1

3

20

High-throughput

0.675

High

1348749

BAHD1
Bromo adjacent homology domain-containing 1 protein

3

2

High-throughput

0.675

High

1414795

ZN581
Zinc finger protein 581

3

20

High-throughput

0.675

High

1063583

GOGA2
Golgin subfamily A member 2

3

19

High-throughput

0.671

High

169734

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

3

6

High-throughput

0.667

High

898794

RL14
Large ribosomal subunit protein eL14

3

4

High-throughput

0.667

High

1274079

CTSR4
Cation channel sperm-associated protein 4

3

5

High-throughput

0.667

High

246911

KDM1A
Lysine-specific histone demethylase 1A

3

6

High-throughput

0.661

High

896874

DYN2
Dynamin-2

3

1

High-throughput

0.660

High

323557

TRI37
E3 ubiquitin-protein ligase TRIM37

1

18

Small-scale

0.647

High

508542

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

1414783

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

15

Small-scale

0.644

High

728410

AKT1
RAC-alpha serine/threonine-protein kinase

3

12

Small-scale

0.640

High

212734

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

2

20

Small-scale

0.639

High

1311775

HOMEZ
Homeobox and leucine zipper protein Homez

2

6

High-throughput

0.633

High

466594

TNR16
Tumor necrosis factor receptor superfamily member 16

2

20

Small-scale

0.629

High

1414787

INO1
Inositol-3-phosphate synthase 1

2

0

High-throughput

0.626

High

520345

ANDR
Androgen receptor

2

20

Small-scale

0.624

High

993731

UBC9
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.621

High

1277998

R144B
E3 ubiquitin-protein ligase RNF144B

1

12

High-throughput

0.621

High

998757

H31
Histone H3.1

1

4

Small-scale

0.618

High

1414774

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

20

Small-scale

0.618

High

1125295

FAK2
Protein-tyrosine kinase 2-beta

2

14

Small-scale

0.611

High

658621

KS6B1
Ribosomal protein S6 kinase beta-1

2

8

Small-scale

0.608

High

124647

EYA2
Protein phosphatase EYA2

2

8

High-throughput

0.606

High

220295

FRS3
Fibroblast growth factor receptor substrate 3

2

2

High-throughput

0.606

High

300599

KRT36
Keratin, type I cuticular Ha6

2

18

High-throughput

0.606

High

478719

HXB5
Homeobox protein Hox-B5

2

19

High-throughput

0.606

High

885386

HXA1
Homeobox protein Hox-A1

2

19

High-throughput

0.606

High

912223

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

2

High-throughput

0.606

High

1005043

RNF4
E3 ubiquitin-protein ligase RNF4

2

15

High-throughput

0.606

High

1032041

TFAP4
Transcription factor AP-4

2

1

High-throughput

0.606

High

1051413

ZBT16
Zinc finger and BTB domain-containing protein 16

2

19

High-throughput

0.606

High

1103087

ZN177
Zinc finger protein 177

2

16

High-throughput

0.606

High

1148554

SF3B4
Splicing factor 3B subunit 4

2

9

High-throughput

0.606

High

1150474

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

10

High-throughput

0.606

High

1187679

T10IP
Testis-specific protein 10-interacting protein

2

1

High-throughput

0.606

High

1225059

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

15

High-throughput

0.606

High

1234934

PKHA7
Pleckstrin homology domain-containing family A member 7

2

20

High-throughput

0.606

High

1241576

CEP85
Centrosomal protein of 85 kDa

2

20

High-throughput

0.606

High

1253081

ZN620
Zinc finger protein 620

2

18

High-throughput

0.606

High

1290956

TAXB1
Tax1-binding protein 1

2

20

High-throughput

0.606

High

1323338

VPS52
Vacuolar protein sorting-associated protein 52 homolog

2

3

High-throughput

0.606

High

1335350

ZN784
Zinc finger protein 784

2

19

High-throughput

0.606

High

1369105

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

9

High-throughput

0.606

High

1400247

LENG8
Leukocyte receptor cluster member 8

2

6

High-throughput

0.606

High

1411220

TIRR
Tudor-interacting repair regulator protein

2

2

High-throughput

0.606

High

1414258

BEGIN
Brain-enriched guanylate kinase-associated protein

2

1

High-throughput

0.606

High

1414773

BACH2
Transcription regulator protein BACH2

2

20

High-throughput

0.606

High

1414775

ZC12C
Probable ribonuclease ZC3H12C

2

5

High-throughput

0.606

High

1414784

ZBT26
Zinc finger and BTB domain-containing protein 26

2

20

High-throughput

0.606

High

1414786

HM20A
High mobility group protein 20A

2

14

High-throughput

0.606

High

1414788

PICK1
PRKCA-binding protein

2

5

High-throughput

0.606

High

1414789

DISC1
Disrupted in schizophrenia 1 protein

2

3

High-throughput

0.606

High

1414791

ZN275
Zinc finger protein 275

2

17

High-throughput

0.606

High

1414796

ABI3
ABI gene family member 3

2

6

High-throughput

0.606

High

1414798

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

2

3

High-throughput

0.606

High

1414799

ZRAN1
Ubiquitin thioesterase ZRANB1

2

20

High-throughput

0.606

High

1414802

ZMYM5
Zinc finger MYM-type protein 5

2

3

High-throughput

0.606

High

1414804

PLAL2
Zinc finger protein PLAGL2

2

20

High-throughput

0.606

High

1414807

ZN835
Zinc finger protein 835

2

11

High-throughput

0.606

High

1414810

ARIP4
Helicase ARIP4

2

5

High-throughput

0.606

High

1094098

RM28
Large ribosomal subunit protein bL28m

2

0

High-throughput

0.601

High

1414792

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

2

0

High-throughput

0.601

High

162681

ANM5
Protein arginine N-methyltransferase 5

2

5

Small-scale

0.601

High

913574

KIF11
Kinesin-like protein KIF11

2

5

Small-scale

0.601

High

1270724

Q7KZS0
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.594

High

1414779

GORS2
Golgi reassembly-stacking protein 2

2

4

High-throughput

0.590

High

1414814

M3K4
Mitogen-activated protein kinase kinase kinase 4

2

7

Small-scale

0.584

High

574453

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

0

High-throughput

0.580

High

1203494

ACTMP
Actin maturation protease

2

0

High-throughput

0.580

High

1293332

EZHIP
EZH inhibitory protein

2

0

High-throughput

0.580

High

269806

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

9

High-throughput

0.573

High

714649

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

High-throughput

0.573

High

991414

SUMO1
Small ubiquitin-related modifier 1

1

10

High-throughput

0.573

High

1115599

ASPP2
Apoptosis-stimulating of p53 protein 2

1

20

High-throughput

0.573

High

1276098

KANL1
KAT8 regulatory NSL complex subunit 1

1

2

High-throughput

0.573

High

1388634

SPDLY
Protein Spindly

1

13

High-throughput

0.573

High

1414777

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

15

High-throughput

0.573

High

1316241

DOCK3
Dedicator of cytokinesis protein 3

2

2

High-throughput

0.571

High

1326797

ARG39
Rho guanine nucleotide exchange factor 39

2

6

High-throughput

0.571

High

412539

NTRK1
High affinity nerve growth factor receptor

1

13

Small-scale

0.561

High

560996

GP1BB
Platelet glycoprotein Ib beta chain

1

1

Small-scale

0.561

High

772520

IRS1
Insulin receptor substrate 1

1

7

Small-scale

0.561

High

1041253

CAV1
Caveolin-1

1

4

Small-scale

0.561

High

1399544

MIA2
Melanoma inhibitory activity protein 2

3

19

High-throughput

0.558

High

163156

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.554

High

65154

GG6L9
Golgin subfamily A member 6-like protein 9

2

20

High-throughput

0.553

High

1410902

GORS1
Golgi reassembly-stacking protein 1

2

4

High-throughput

0.553

High

1414793

GOG6A
Golgin subfamily A member 6A

2

20

High-throughput

0.553

High

1414808

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.549

High

1414813

RN114
E3 ubiquitin-protein ligase RNF114

1

19

High-throughput

0.541

High

1372063

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.536

High

300691

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.536

High

363802

EGFR
Epidermal growth factor receptor

1

14

Small-scale

0.536

High

1213141

BEND3
BEN domain-containing protein 3

1

2

High-throughput

0.536

High

1369480

TANK
TRAF family member-associated NF-kappa-B activator

1

10

High-throughput

0.536

High

1414790

SALL1
Sal-like protein 1

1

10

High-throughput

0.536

High

1414801

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.536

High

128574

ATOX1
Copper transport protein ATOX1

1

0

Small-scale

0.529

High

772990

MYH9
Myosin-9

1

9

Small-scale

0.515

High

849435

TNR4
Tumor necrosis factor receptor superfamily member 4

1

20

Small-scale

0.515

High

905663

IRAK1
Interleukin-1 receptor-associated kinase 1

1

11

Small-scale

0.515

High

1057696

TNR9
Tumor necrosis factor receptor superfamily member 9

1

20

Small-scale

0.515

High

1307145

TCAM1
TIR domain-containing adapter molecule 1

1

11

Small-scale

0.515

High

59962

A2BDE7
PHLDA1 protein

1

2

High-throughput

0.515

High

69900

A8KA13
B-cell CLL/lymphoma 6 member B protein

1

20

High-throughput

0.515

High

647642

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

3

High-throughput

0.515

High

1287944

Q86U76
Zinc finger protein 3

1

19

High-throughput

0.515

High

1311687

GOR
Putative exonuclease GOR

1

1

High-throughput

0.515

High

1361575

ING5
Inhibitor of growth protein 5

1

0

High-throughput

0.513

High

1095780

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

Small-scale

0.508

High

1207809

GASP1
G-protein coupled receptor-associated sorting protein 1

1

1

Small-scale

0.508

High

1218007

MYOME
Myomegalin

1

20

Small-scale

0.508

High

1396118

Z512B
Zinc finger protein 512B

1

17

High-throughput

0.508

High

1407027

NPAS2
Neuronal PAS domain-containing protein 2

1

15

Small-scale

0.508

High

177937

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.501

High

185981

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

787581

TNR3
Tumor necrosis factor receptor superfamily member 3

1

20

Small-scale

0.501

High

160756

TOR1A
Torsin-1A

1

0

High-throughput

0.493

High

1323259

CARTF
Calcium-responsive transcription factor

1

0

High-throughput

0.493

High

391657

FRIH
Ferritin heavy chain

1

1

Small-scale

0.481

High

505762

ZN688
Zinc finger protein 688

1

20

High-throughput

0.481

High

1035534

CENPE
Centromere-associated protein E

1

3

Small-scale

0.481

High

1322881

BCL6B
B-cell CLL/lymphoma 6 member B protein

1

20

High-throughput

0.481

High

1357665

PHLA1
Pleckstrin homology-like domain family A member 1

1

2

High-throughput

0.481

High

1398045

FXL18
F-box/LRR-repeat protein 18

1

1

High-throughput

0.481

High

1414797

MAGC2
Melanoma-associated antigen C2

1

7

Small-scale

0.481

High

1414805

EXOC7
Exocyst complex component 7

1

1

High-throughput

0.481

High

214017

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

20

Small-scale

0.479

High

214457

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

20

Small-scale

0.479

High

411032

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

13

Small-scale

0.479

High

488546

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

4

Small-scale

0.479

High

521906

H14
Histone H1.4

1

10

Small-scale

0.479

High

573229

KPYM
Pyruvate kinase PKM

1

4

Small-scale

0.479

High

615951

RL17
Large ribosomal subunit protein uL22

1

4

Small-scale

0.479

High

626466

NCF2
Neutrophil cytosol factor 2

1

6

Small-scale

0.479

High

683328

TNR5
Tumor necrosis factor receptor superfamily member 5

1

20

Small-scale

0.479

High

686387

RL13
Large ribosomal subunit protein eL13

1

4

Small-scale

0.479

High

765001

CTNB1
Catenin beta-1

1

8

Small-scale

0.479

High

765848

BMI1
Polycomb complex protein BMI-1

1

18

High-throughput

0.479

High

787447

TGFR1
TGF-beta receptor type-1

1

5

Small-scale

0.479

High

789008

TGFR2
TGF-beta receptor type-2

1

6

Small-scale

0.479

High

789563

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

859046

RL27A
Large ribosomal subunit protein uL15

1

1

Small-scale

0.479

High

944060

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

Small-scale

0.479

High

967540

RS7
Small ribosomal subunit protein eS7

1

1

Small-scale

0.479

High

978693

RL23A
Large ribosomal subunit protein uL23

1

3

Small-scale

0.479

High

985313

RL10A
Large ribosomal subunit protein uL1

1

5

Small-scale

0.479

High

1037619

RL18A
Large ribosomal subunit protein eL20

1

4

Small-scale

0.479

High

1114173

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1131115

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

12

Small-scale

0.479

High

1137496

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.479

High

1139826

SETB1
Histone-lysine N-methyltransferase SETDB1

1

5

Small-scale

0.479

High

1307780

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

18

Small-scale

0.479

High

1367161

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1406379

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

Small-scale

0.479

High

1414772

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

1

Small-scale

0.479

High

1414782

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

11

Small-scale

0.479

High

1414785

GPVI
Platelet glycoprotein VI

1

5

Small-scale

0.479

High

1414806

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

11

Small-scale

0.479

High

1414809

TRRAP
Transformation/transcription domain-associated protein

1

9

High-throughput

0.479

High

1414811

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

20

Small-scale

0.479

High

1386992

Q96D16
FBXL18 protein

1

1

High-throughput

0.470

High

1414778

RPB1C
DNA-directed RNA polymerase II subunit RPB11-b2

1

2

High-throughput

0.470

High

1295100

F90A1
Protein FAM90A1

1

1

High-throughput

0.464

High

1127598

FAT1
Protocadherin Fat 1

1

0

Small-scale

0.460

High

1383238

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

3395

A0A0S2Z4Q4
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

6

High-throughput

0.457

High

3477

A0A0S2Z5G4
Protein BANP

1

4

High-throughput

0.457

High

3562

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

19

High-throughput

0.457

High

75873

B4DE54
Protein BANP

1

4

High-throughput

0.457

High

1414815

X5D7T2
Aryl hydrocarbon receptor nuclear translocator 2

1

15

High-throughput

0.457

High

1414816

X5D9H9
Aryl-hydrocarbon receptor nuclear translocator 2 isoform B

1

16

High-throughput

0.457

High

1414817

X5DP31
Aryl hydrocarbon receptor nuclear translocator 2

1

15

High-throughput

0.457

High

1414776

RPB1B
DNA-directed RNA polymerase II subunit RPB11-b1

1

2

High-throughput

0.439

High

1226512

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.437

High

337135

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.426

High

403004

ANXA1
Annexin A1

1

7

Small-scale

0.408

High

3661

DP2NB
DPEP2 neighbor protein

1

0

High-throughput

0.268

Low

96988

NPIA7
Nuclear pore complex-interacting protein family member A7

1

0

High-throughput

0.268

Low

163587

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.268

Low

1385079

Q96BU6
EXOC7 protein

1

0

High-throughput

0.268

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025