HitPredict

Interactor 1: MECP2 (P51608)
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Gene: MECP2

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 0.60 0.744

The method score is based on:

Property Details
Experiments 9620779, 14593184, 9620804, 10773092, 15322089, 22615490, 23770565
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity
GO:0003723 - RNA binding
and 5 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 486
Hs

1 1273
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024