Protein: SIN3B
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)

Gene: SIN3B
Organism: Homo sapiens
Interactions: 142
UniProt ID: O75182

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000805 - X chromosome
GO:0000806 - Y chromosome
GO:0001741 - XY body

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

274324

HDAC1
Histone deacetylase 1

14

18

Small-scale

0.981

High

274391

MO4L1
Mortality factor 4-like protein 1

10

5

Small-scale

0.971

High

274334

RBBP7
Histone-binding protein RBBP7

7

9

High-throughput

0.965

High

274382

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

5

9

Small-scale

0.933

High

274363

HDAC2
Histone deacetylase 2

5

18

Small-scale

0.908

High

274285

KDM5A
Lysine-specific demethylase 5A

4

2

Small-scale

0.903

High

274331

MO4L2
Mortality factor 4-like protein 2

5

5

Small-scale

0.902

High

274315

RBBP4
Histone-binding protein RBBP4

4

9

High-throughput

0.900

High

274369

PHF12
PHD finger protein 12

4

17

High-throughput

0.895

High

274269

SAP30
Histone deacetylase complex subunit SAP30

4

4

Small-scale

0.892

High

274371

SIN3A
Paired amphipathic helix protein Sin3a

2

3

High-throughput

0.811

High

274379

ING2
Inhibitor of growth protein 2

2

10

High-throughput

0.811

High

274358

GATD1
GATA zinc finger domain-containing protein 1

5

1

High-throughput

0.714

High

274346

EMSY
BRCA2-interacting transcriptional repressor EMSY

4

6

High-throughput

0.694

High

274395

ING1
Inhibitor of growth protein 1

1

11

High-throughput

0.691

High

274385

SHCAF
SIN3-HDAC complex-associated factor

4

1

Small-scale

0.691

High

274377

SP130
Histone deacetylase complex subunit SAP130

3

7

High-throughput

0.667

High

274274

MYC
Myc proto-oncogene protein

3

19

Small-scale

0.656

High

274338

ARI4B
AT-rich interactive domain-containing protein 4B

3

8

High-throughput

0.650

High

274399

HDAC9
Histone deacetylase 9

1

19

Small-scale

0.647

High

274275

ESR1
Estrogen receptor

3

6

Small-scale

0.633

High

190102

TNC18
Trinucleotide repeat-containing gene 18 protein

2

4

High-throughput

0.628

High

274373

PHF23
PHD finger protein 23

2

2

High-throughput

0.628

High

274273

NSD2
Histone-lysine N-methyltransferase NSD2

1

5

Small-scale

0.618

High

274306

H31
Histone H3.1

1

5

High-throughput

0.618

High

274317

BPTF
Nucleosome-remodeling factor subunit BPTF

1

4

High-throughput

0.618

High

274319

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

10

High-throughput

0.618

High

274339

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

9

High-throughput

0.618

High

274356

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

10

High-throughput

0.618

High

274357

SAP25
Histone deacetylase complex subunit SAP25

1

2

Small-scale

0.618

High

274365

PF21A
PHD finger protein 21A

1

17

High-throughput

0.618

High

274384

BRMS1
Breast cancer metastasis-suppressor 1

1

9

Small-scale

0.618

High

274400

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

9

Small-scale

0.618

High

274320

REST
RE1-silencing transcription factor

2

1

Small-scale

0.611

High

274284

ARI4A
AT-rich interactive domain-containing protein 4A

2

9

Small-scale

0.611

High

274392

DAXX
Death domain-associated protein 6

2

1

High-throughput

0.601

High

274281

ANDR
Androgen receptor

2

6

Small-scale

0.584

High

274323

IKZF1
DNA-binding protein Ikaros

2

7

Small-scale

0.584

High

274341

RN220
E3 ubiquitin-protein ligase RNF220

1

1

Small-scale

0.578

High

274313

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

Small-scale

0.573

High

274388

MRGBP
MRG/MORF4L-binding protein

2

0

Small-scale

0.559

High

274276

P53
Cellular tumor antigen p53

1

2

Small-scale

0.552

High

274289

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

0

Small-scale

0.551

High

274295

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.536

High

274309

FOXK2
Forkhead box protein K2

1

7

High-throughput

0.536

High

274312

AKA12
A-kinase anchor protein 12

1

2

High-throughput

0.536

High

274326

FHL2
Four and a half LIM domains protein 2

1

1

High-throughput

0.536

High

274342

TASO2
Protein TASOR 2

1

3

High-throughput

0.536

High

274351

TF2LX
Homeobox protein TGIF2LX

1

5

High-throughput

0.536

High

274360

BBX
HMG box transcription factor BBX

1

7

High-throughput

0.536

High

274401

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

1

High-throughput

0.536

High

274336

H31T
Histone H3.1t

1

5

High-throughput

0.527

High

274300

HCFC1
Host cell factor 1

1

3

Small-scale

0.515

High

224559

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.513

High

274321

STX3
Syntaxin-3

1

0

High-throughput

0.513

High

274337

RN151
RING finger protein 151

1

0

High-throughput

0.513

High

274387

MYO5C
Unconventional myosin-Vc

1

0

High-throughput

0.513

High

169847

AURKA
Aurora kinase A

1

2

Small-scale

0.501

High

274298

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

16

Small-scale

0.501

High

274299

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

17

Small-scale

0.501

High

274304

CSN2
COP9 signalosome complex subunit 2

1

1

Small-scale

0.501

High

274316

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

2

Small-scale

0.501

High

274329

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

5

Small-scale

0.501

High

274364

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

1

Small-scale

0.501

High

274288

SCN4A
Sodium channel protein type 4 subunit alpha

1

1

High-throughput

0.489

High

274352

SULF2
Extracellular sulfatase Sulf-2

1

1

High-throughput

0.489

High

142749

NFIB
Nuclear factor 1 B-type

1

7

High-throughput

0.479

High

155266

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

1

High-throughput

0.479

High

246334

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.479

High

247190

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.479

High

270222

MTG16
Protein CBFA2T3

1

2

Small-scale

0.479

High

274270

E2F6
Transcription factor E2F6

1

2

Small-scale

0.479

High

274271

MTA2
Metastasis-associated protein MTA2

1

8

High-throughput

0.479

High

274272

MBD3
Methyl-CpG-binding domain protein 3

1

4

High-throughput

0.479

High

274279

NFIC
Nuclear factor 1 C-type

1

8

High-throughput

0.479

High

274280

MYBB
Myb-related protein B

1

5

High-throughput

0.479

High

274282

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

274283

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

17

High-throughput

0.479

High

274290

PBX1
Pre-B-cell leukemia transcription factor 1

1

6

Small-scale

0.479

High

274293

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

274296

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.479

High

274297

MXI1
Max-interacting protein 1

1

17

Small-scale

0.479

High

274302

ZN131
Zinc finger protein 131

1

2

High-throughput

0.479

High

274303

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

2

High-throughput

0.479

High

274305

H4
Histone H4

1

2

High-throughput

0.479

High

274307

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

274310

MYT1
Myelin transcription factor 1

1

2

Small-scale

0.479

High

274311

TFAP4
Transcription factor AP-4

1

2

Small-scale

0.479

High

274318

NFIA
Nuclear factor 1 A-type

1

8

High-throughput

0.479

High

274322

MTA1
Metastasis-associated protein MTA1

1

8

High-throughput

0.479

High

274325

KLF9
Krueppel-like factor 9

1

10

High-throughput

0.479

High

274327

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

High-throughput

0.479

High

274328

NFIX
Nuclear factor 1 X-type

1

7

High-throughput

0.479

High

274330

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

19

High-throughput

0.479

High

274332

SETB1
Histone-lysine N-methyltransferase SETDB1

1

3

Small-scale

0.479

High

274333

ELF2
ETS-related transcription factor Elf-2

1

4

High-throughput

0.479

High

274335

SMN
Survival motor neuron protein

1

1

Small-scale

0.479

High

274340

LIN9
Protein lin-9 homolog

1

3

High-throughput

0.479

High

274343

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

274345

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

274347

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

1

Small-scale

0.479

High

274348

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

274350

P66A
Transcriptional repressor p66-alpha

1

5

High-throughput

0.479

High

274353

BAP18
BPTF-associated chromatin complex component 1

1

1

High-throughput

0.479

High

274355

SP7
Transcription factor Sp7

1

12

High-throughput

0.479

High

274359

P66B
Transcriptional repressor p66-beta

1

5

High-throughput

0.479

High

274361

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

274362

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

274366

LIN37
Protein lin-37 homolog

1

1

High-throughput

0.479

High

274367

Z512B
Zinc finger protein 512B

1

3

High-throughput

0.479

High

274368

PWP2A
PWWP domain-containing protein 2A

1

4

High-throughput

0.479

High

274370

CIC
Protein capicua homolog

1

9

High-throughput

0.479

High

274372

MTA3
Metastasis-associated protein MTA3

1

11

High-throughput

0.479

High

274374

KLF16
Krueppel-like factor 16

1

10

Small-scale

0.479

High

274376

WWTR1
WW domain-containing transcription regulator protein 1

1

3

High-throughput

0.479

High

274378

BRD8
Bromodomain-containing protein 8

1

6

High-throughput

0.479

High

274380

BC11A
BCL11 transcription factor A

1

1

High-throughput

0.479

High

274381

IKZF4
Zinc finger protein Eos

1

7

Small-scale

0.479

High

274389

ZBTB4
Zinc finger and BTB domain-containing protein 4

1

1

Small-scale

0.479

High

274390

MBD2
Methyl-CpG-binding domain protein 2

1

4

High-throughput

0.479

High

274396

RCOR1
REST corepressor 1

1

11

High-throughput

0.479

High

274397

IKZF2
Zinc finger protein Helios

1

7

Small-scale

0.479

High

274398

IKZF3
Zinc finger protein Aiolos

1

7

Small-scale

0.479

High

274278

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

274286

C2TA
MHC class II transactivator

1

0

Small-scale

0.458

High

274287

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.458

High

274291

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

274292

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.458

High

274301

ZN157
Zinc finger protein 157

1

0

High-throughput

0.458

High

274349

PALB2
Partner and localizer of BRCA2

1

0

High-throughput

0.458

High

274375

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.458

High

274394

XPO7
Exportin-7

1

0

High-throughput

0.458

High

274402

MOFA1
MORF4 family-associated protein 1

1

0

High-throughput

0.458

High

274354

MIER1
Mesoderm induction early response protein 1

1

8

High-throughput

0.445

High

274314

GOGA2
Golgin subfamily A member 2

1

2

High-throughput

0.437

High

274393

HMGX4
HMG domain-containing protein 4

1

8

High-throughput

0.437

High

274294

RFX5
DNA-binding protein RFX5

1

0

Small-scale

0.426

High

274383

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

274386

PLPL8
Calcium-independent phospholipase A2-gamma

1

0

High-throughput

0.279

Low

274277

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

274308

NDP
Norrin

1

0

Small-scale

0.249

Low

274344

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025