HitPredict

Interactor 1: MECP2 (P51608)
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Gene: MECP2

Interactor 2: NLE1 (Q9NVX2)
Notchless protein homolog 1
Gene: NLE1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0007219 - Notch signaling pathway
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 486 Hs			1 485
+	Hs
		848120 MECP2_HUMAN (1-486): 5.16e-113: 344: 100.00		TBL1R_HUMAN (241-484): 1.58e-59: 205: 22.39
+	Mm
		1206590 MECP2_MOUSE (1-486): 5.34e-112: 341: 94.44		TBL1R_MOUSE (241-484): 2.52e-59: 205: 22.02
+	Hs
		245580 MECP2_HUMAN (1-486): 5.16e-113: 344: 100.00		TBL1X_HUMAN (3-86): 9.69e-16: 81.6: 11.91
+	Hs
		1281461 MBD1_HUMAN (95-220): 6.98e-31: 127: 31.78		FBXW7_HUMAN (6-352): 2.75e-69: 236: 21.41