HitPredict

Interactor 1: HCFC1 (P51610)
Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
Gene: HCFC1

Interactor 2: SET1B (Q9UPS6)
Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)
Gene: SETD1B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0035097 - histone methyltransferase complex GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2035 Hs			1 1966
+	Hs
		848317 HCFC1_HUMAN (1-2035): 0: 643: 100.00		KMT2B_HUMAN (1069-1966): 4.68e-71: 268: 21.69
+	Hs
		848199 HCFC1_HUMAN (1-2035): 0: 643: 100.00		KMT2A_HUMAN (1173-1966): 2.68e-66: 252: 21.73
+	Mm
		876679 HCFC1_MOUSE (1-2035): 0: 609: 92.28		KMT2A_MOUSE (1369-1966): 8.01e-74: 277: 24.76
+	Hs
		848225 HCFC1_HUMAN (1-2035): 0: 643: 100.00		EZH2_HUMAN (1464-1949): 9.8e-64: 235: 15.84
+	Hs
		848256 HCFC1_HUMAN (1-2035): 0: 643: 100.00		KMT2C_HUMAN (1759-1966): 1.32e-58: 227: 37.04
+	Hs
		165649 HCFC1_HUMAN (1-2035): 0: 643: 100.00		SET1A_HUMAN (409-1966): 1e-54: 214: 22.13
+	Hs
		152616 HCFC1_HUMAN (1-2035): 0: 643: 100.00		KMT2D_HUMAN (1826-1966): 3.07e-17: 91.3: 46.85
+	Hs
		1357739 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		SET1B_HUMAN (1-1966): 3.57e-162: 549: 100.00
+	Hs
		1080502 KLDC2_HUMAN (5-403): 2.43e-73: 253: 20.92		EZH2_HUMAN (1464-1949): 9.8e-64: 235: 15.84
+	Hs
		203776 KLDC3_HUMAN (68-425): 9.22e-58: 207: 21.14		SUV91_HUMAN (1686-1965): 2.95e-70: 244: 17.93
+	Hs
		203817 KLH20_HUMAN (2-263): 2.49e-55: 206: 14.39		SUV91_HUMAN (1686-1965): 2.95e-70: 244: 17.93
+	Hs
		1357298 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		KMT2B_HUMAN (1069-1966): 4.68e-71: 268: 21.69
+	Hs
		975356 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		KMT2A_HUMAN (1173-1966): 2.68e-66: 252: 21.73
+	Dm
		1215702 HCF_DROME (948-2031): 9.87e-34: 144: 15.87		TRR_DROME (1759-1966): 1.74e-65: 249: 35.62
+	Dm
		785649 Q9W3D5_DROME (137-414): 1.2e-40: 158: 22.87		EZ_DROME (1697-1945): 6.26e-63: 233: 22.96
+	Hs
		1243854 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		KMT2C_HUMAN (1759-1966): 1.32e-58: 227: 37.04
+	Hs
		165746 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		SET1A_HUMAN (409-1966): 1e-54: 214: 22.13
+	Dm
		1129077 HCF_DROME (948-2031): 9.87e-34: 144: 15.87		SET1_DROME (30-197): 5.94e-53: 208: 38.60
+	Hs
		152704 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		KMT2D_HUMAN (1826-1966): 3.07e-17: 91.3: 46.85
+	Zm
		35425 A0A1D6PPA8_MAIZE (105-562): 2.75e-33: 141: 15.91		A0A1D6LLI6_MAIZE (1833-1945): 1.29e-15: 85.1: 36.28