HitPredict

Interactor 1: IRAK1 (P51617)
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
Gene: IRAK1

Interactor 2: IRAK4 (Q9NWZ3)
Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)
Gene: IRAK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.985

The method score is based on:

Property Details
Experiments 28512203, 17276401, 17785851, 19166926, 16951688, 16024789, 11960013, 18221795, 21903422, 12538665, 12860405, 24735611, 15084582
Identification Methods affinity chromatography technology, enzymatic study, protein complementation assay, two hybrid, anti tag coimmunoprecipitation, in-gel kinase assay
Interaction Type physical association, direct interaction, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Pkinase
Common GO terms GO:0002224 - toll-like receptor signaling pathway
GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 19 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 712
Hs

1 460
+ Mm
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
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+ At
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+ At
+ At
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Last updated: 15 Jul 2024